Objective To explore the influencing factors for delayed resuscitation from anaesthesia in patients undergoing pancreatic cancer surgery and to develop a prediction model and evaluate its predictive performance.Methods This study included 300 patients who had surgery under general anaesthesia for pancreatic cancer at a Tier-IIIA hospital in Jiangsu Province between September 2023 and February 2024.The patients who had the surgery between September and December 2023(n=208)were assigned to the modelling group,and those between January to February 2024(n=92)to the validation group.Baseline perioperative data were recorded.Binary logistic regression was used to identify risk factors for delayed resuscitation,and a risk prediction model was finally developed and validated.Results Over 60 years of age,bispectral index(BIS)monitoring,combined with regional block anaesthesia,and rescue analgesia were identified as the risk factors for delayed resuscitation(all P<0.05).The Hosmer-Lemeshow test confirmed a good model fit(P>0.05).The C-index value was 0.807 for the modelling group and 0.841 for the validation group.The area under the curve(AUC)of receiver operating characteristic(ROC)was 0.807(95%CI 0.738～0.876)for the modelling group and 0.841(95%CI 0.742～0.940)for the validation group,with both calibration curves close to the ideal curve.Conclusion The developed prediction model for delayed resuscitation exhibits a good predictive performance and it can serve as a reference for clinical staff.

Objective To explore the influencing factors for delayed resuscitation from anaesthesia in patients undergoing pancreatic cancer surgery and to develop a prediction model and evaluate its predictive performance.Methods This study included 300 patients who had surgery under general anaesthesia for pancreatic cancer at a Tier-IIIA hospital in Jiangsu Province between September 2023 and February 2024.The patients who had the surgery between September and December 2023(n=208)were assigned to the modelling group,and those between January to February 2024(n=92)to the validation group.Baseline perioperative data were recorded.Binary logistic regression was used to identify risk factors for delayed resuscitation,and a risk prediction model was finally developed and validated.Results Over 60 years of age,bispectral index(BIS)monitoring,combined with regional block anaesthesia,and rescue analgesia were identified as the risk factors for delayed resuscitation(all P<0.05).The Hosmer-Lemeshow test confirmed a good model fit(P>0.05).The C-index value was 0.807 for the modelling group and 0.841 for the validation group.The area under the curve(AUC)of receiver operating characteristic(ROC)was 0.807(95%CI 0.738～0.876)for the modelling group and 0.841(95%CI 0.742～0.940)for the validation group,with both calibration curves close to the ideal curve.Conclusion The developed prediction model for delayed resuscitation exhibits a good predictive performance and it can serve as a reference for clinical staff.

OBJECTIVE:To explore the effect of administration timing of mannitol on efficacy and related indexes of patients with moderate cerebral hemorrhage. METHODS:Data of 280 patients with moderate cerebral hemorrhage being treated with manni-tol were divided into super-early group(65 cases),early group(97 cases)and extension group(118 cases)was analyzed retrospec-tively according to administration timing. All patients received conservative medical treatment,ntrition brain cells and other symp-tomatic and supportive treatment. Based on it,super-early group received mannitol within 6 h of cerebral hemorrhage,early group received mannitol within 6-24 h,and extension group received mannitol more than 24 h. Clinical efficacy,incidence of hematoma enlargement,mortality,incidence of continued bleeding/rebleeding and incidence of adverse reactions in 3 groups were observed. RESULTS:The incidences of hematoma enlargement and mortality in early group and extension group were significantly lower than super-early group,the differences were statistically significant (P<0.05);but there were no significant differences between early group and extension group (P>0.05). The total effective rate in early group was significantly higher than super-early group and extension group,the incidence of continued bleeding/rebleeding was significantly lower than super-early group and extension group,the differences were statistically significant (P<0.05);but there no significant differences between super-early group and extension group (P>0.05). CONCLUSIONS:Based on conventional treatment,mannitol shows better efficacy for patients with moderate cerebral hemorrhage within 6-24 h of cerebral hemorrhage than those in super-early or extension. It can reduce continued bleeding/rebleeding incidence,and has equivalent safety.