Objective:To analyze the clinical characteristics and treatment outcomes of children with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody-mediated necrotizing myopathy, and to explore early identification and management strategies to provide reference for clinical diagnosis and treatment.Methods:A retrospective analysis was conducted on the clinical data and treatment outcomes of 10 pediatric patients with anti-HMGCR antibody-mediated necrotizing myopathy admitted to the Department of Rheumatology, Children′s Hospital of Fudan University from December 2020 to December 2024. Statistical description was performed using SPSS 22.0.Results:Among the 10 patients, the male-to-female ratio was 1:4, the age of onset was (7.2±4.0) years, and the disease duration at diagnosis was (22.2±19.6) months. None had a history of statin exposure. Six patients presented with muscle weakness, and4 were diagnosed due to asymptomatic elevation of creatine kinase (CK); 4 had dermatomyositis-like rashes. All patients showed significantly elevated CK levels [median 3 291(1 969, 8 776)U/L] and underwent muscle biopsy. Histopathological findings revealed myofiber degeneration, necrosis, and regeneration in all cases, with inflammatory infiltration in 9 cases, MHC-Ⅰ positivity in all, and C5b-9 positivity in 9 cases. The median follow-up duration was (15.7±6.3) months. At the last follow-up, muscle strength was normal or nearly normal, and the CK median value had decreased to 977.5 (211.0, 3 536.0) U/L.Conclusion:For patients with suspected idiopathic inflammatory myopathy and significantly elevated CK, muscle-specific antibody testing-including anti-HMGCR-and muscle biopsy should be performed promptly regardless of the presence of skin rash, to ensure accurate diagnosis and guide treatment, thereby avoiding misdiagnosis or missed diagnosis.

Objective:To analyze the clinical characteristics and treatment outcomes of children with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody-mediated necrotizing myopathy, and to explore early identification and management strategies to provide reference for clinical diagnosis and treatment.Methods:A retrospective analysis was conducted on the clinical data and treatment outcomes of 10 pediatric patients with anti-HMGCR antibody-mediated necrotizing myopathy admitted to the Department of Rheumatology, Children′s Hospital of Fudan University from December 2020 to December 2024. Statistical description was performed using SPSS 22.0.Results:Among the 10 patients, the male-to-female ratio was 1:4, the age of onset was (7.2±4.0) years, and the disease duration at diagnosis was (22.2±19.6) months. None had a history of statin exposure. Six patients presented with muscle weakness, and4 were diagnosed due to asymptomatic elevation of creatine kinase (CK); 4 had dermatomyositis-like rashes. All patients showed significantly elevated CK levels [median 3 291(1 969, 8 776)U/L] and underwent muscle biopsy. Histopathological findings revealed myofiber degeneration, necrosis, and regeneration in all cases, with inflammatory infiltration in 9 cases, MHC-Ⅰ positivity in all, and C5b-9 positivity in 9 cases. The median follow-up duration was (15.7±6.3) months. At the last follow-up, muscle strength was normal or nearly normal, and the CK median value had decreased to 977.5 (211.0, 3 536.0) U/L.Conclusion:For patients with suspected idiopathic inflammatory myopathy and significantly elevated CK, muscle-specific antibody testing-including anti-HMGCR-and muscle biopsy should be performed promptly regardless of the presence of skin rash, to ensure accurate diagnosis and guide treatment, thereby avoiding misdiagnosis or missed diagnosis.

Objective:To explore the relationship between subjective social status (SSS) and mental health (depression, anxiety, and flourishing) among medical students, and to examine the moderating role of self-compassion in this process.Methods:The Chinese version of the subjective socioeconomic status scale (CSSS), self-compassion scale (SCS), patient health questionnaire (PHQ-9), generalized anxiety disorder (GAD-7) and flourishing scale (FS) were used to investigate 2 440 medical students in December 2021. SPSS 26.0 software was used for descriptive statistics and correlation analysis. Multilevel regression analysis was used to investigate the moderating role of self-compassion on the relationship between SSS and mental health.Results:(1) Correlation analysis showed that SSS(5.32±1.46)was negatively correlated with depression(5.00(3.00, 8.00))and anxiety(3.00(1.00, 6.00)) ( r=-0.166, -0.128, both P<0.01), and was positively correlated with flourishing(40.69±8.45)( r=0.242, P<0.01). Self-compassion(86.63±13.16)was negatively correlated with depression and anxiety ( r=-0.538, -0.511, both P<0.01), and was positively correlated with flourishing ( r=0.543, P<0.01). (2) Multilevel regression analysis showed that SSS could significantly and negatively predict depression( β=-0.065, P<0.001), and positively predict flourishing( β=0.157, P<0.001). Self-compassion played a significantly positive moderating role in the relationship between SSS and depression( β=0.055, P<0.01), and the negative relationship between SSS and depression decreased with increasing self-compassion.Self-compassion played a significantly negative moderating role in the relationship between SSS and flourishing( β=-0.037, P<0.05), the positive relationship between SSS and flourishing decreased with increasing self-compassion. Conclusion:SSS can predict mental health of medical students.Self-compassion plays a moderating role in the relationship between SSS and mental health and can mitigate the damage of low SSS on the mental health of medical students.

Background: Numerous studies among the western population have been demonstrated that the intolerance of uncertainty can cause mental disorders such as OCD, anxiety disorder major depressive disorder. The lack of research in this field among the eastern population, especially the Mongolians, is the basis of our study. Material and Methods The study was designed as a cross-sectional study with a self-report questionnaire and conducted between December 5th and February 5th of 2022. The Intolerance of Uncertainty scale (IUS-12) is for measuring intolerance of uncertainty, Patient health questionnaire (PHQ-9), and Generalized anxiety disorder (GAD-7) were used to measuring mental health among study participants. The present study was undertaken following ethical approval from the MNUMS scientific research ethics committee (approval number: 2021/3-06). Statistical analysis was performed using SPSS version 24. Purpose: The current study was aimed to explore the impact of intolerance of uncertainty on students’ mental health. Results: Total of 3137 students (2440 Chinese, 697 Mongolian), 65.7% of them were female students participated in the current study. The mean score of IUS-12 was 33.53±7.72 among Chinese students, while 38.65±8.48 among Mongolians. This reveals the statistically significant (p=0.003) difference intolerance level between Chinese and Mongolian students. Moreover, Chinese students were less depressed and less anxious than Mongolian students. The anxiety and depression level was directly impacted by the influence of intolerance of uncertainty. Conclusion Chinese students are more tolerant toward uncertainties than Mongolian students. The intolerance of uncertainty causes depression and anxiety, regardless of nationality.

Objective:To explore the mediating effect of humor styles between individual authenticity and depression among college students.Methods:A total of 247 college students were surveyed by the humor styles questionnaire, the authenticity questionnaire and the Chinese version of the Beck depression inventory-Ⅱ.SPSS 26.0 was used for descriptive statistics and correlation analysis, and AMOS 23.0 software was used for structural equation model test.The Bootstrap method was applied to test the mediating effect.Results:(1)The individual authenticity score was (53.35±7.80), the depression score was 6.00(3.00, 11.00), and the scores of self-defeating, self-enhancing and affiliative humor styles were (15.00±3.45), (17.70±3.04) and (27.21±4.17). (2) Correlation analysis showed that individual authenticity was positively correlated with self-enhancing humor ( r=0.20, P<0.01), and negatively correlated with self-defeating humor and depression ( r=-0.16, P<0.05; r=-0.30, P<0.01). Self-enhancing humor was negatively correlated with depression ( r=-0.17, P<0.01). (3) The results of mediating analysis showed that the total effect between self-enhancing humor and depression was -0.318.The self-enhancing humor style had a partial mediating effect between individual authenticity and depression, with an effect value of -0.055 (95% CI=-0.103, -0.007), accounting for 17.3% of the total effect.The direct effect value of individual authenticity on depression was -0.245 (95% CI=-0.376, -0.119), accounting for 77.0% of the total effect. Conclusion:It indicates that individual authenticity can directly affect depression and also can affect depression through self-enhancing humor.It is helpful to understand the relationship between individual authenticity and mental health, and provide a strategic reference for preventing and intervention of depression among college students.

Objective To investigate the effect of the high school students' authenticity in the relationships with parents and friends on their behavior problems and loneliness.Methods A total of 619 high school students in Guangdong province participated in this study.The instruments included the Authenticity Scale,the Youth Self-Report and the State versus Trait Loneliness Scales.Results (1) Authentic self in the relationship with parents were significantly and negatively related to internalizing problems (depression/anxiety,social withdrawal and somatic complaints,standardized regression coefficients were-0.17,P ＜ 0.01 ;-0.10,P ＜ 0.05 ;-0.10,P ＜ 0.05),externalizing problems (aggression and delinquency,standardized regression coefficients were -0.16,P ＜ 0.01 ;-0.21,P ＜ 0.01) and loneliness (trait loneliness and state loneliness,standardized regression coefficients were-0.17,P ＜0.01 ;-0.17,P ＜0.01).(2) Authentic self in the relationship with friends was significantly and negatively related to internalizing problems (depression/anxiety,social withdrawal and somatic complaints,standardized regression coefficients were-0.24,P＜ 0.01 ;-0.28,P＜ 0.01 ;-0.10,P＜ 0.05) and loneliness(trait loneliness and state loneliness,standardized regression coefficients were-0.29,P ＜ 0.01;-0.34,P ＜0.01).Conclusion Authenticity in the relationships with parents and friends has the positive effect on adolescents' psychosocial adjustment.