Objective: Our purpose was to evaluate a new kind of tomographic phase analysis in Wolff-Parkinson-White (WPW) syndrome . Methods:Planar and new tomographic gated blood pool scintigraphy were performed in 66 patients with WPW syndrome and 55 healthy subjects , in which 30 patients were examined again after radiofrequency ablation . The abnormal initial contractions in both planar and tomographic phase image were compared with the sites of accessory pathway (ACP) based on ECG and radiofrequency ablation .Results:The phase angle shift in WPW group was significantly different from that in healthy subjects .New tomographic phase analysis can detect the sites of ACP more precisely than planar phase analysis and ECG ( 93.9%, 80.3%, 79.0%, respectively ).The average phase angle shift in WPW group after operation was less than that before operation (P< 0.01 ) .Tomographic phase analysis discovered two mutiple ACPs and latent ACP that can not be found by ECG. Conclusion:The new tomographic phase analysis is a promising method to detect the sites of ACP and can be used to evaluate the efficacy of operation.

OBJECTIVE:To measure the concentrations of levofloxacin in aqueous humor after a single eye dripping of drug and calculate the pharmacokinetic parameters.METHODS:32 rabbits were divided into 8 groups.The rabbit eyeballs were enucleated to make a collection of aqueous humor at 0.125,0.25,0.5,0.75,1.0,2.0,3.0 and 4.0 hours after dripping.All measurements were performed with HPLC.RESULTS:In aqueous humor,Tmax:0.940h,Cmax:0.592?g/ml,T1/2(Ka):0.479h,T1/2 (Ke)0.919h.By using 3p87 pharmacokinetic program,the concentration-time curves were fitted as one-compartment op_en model.CONCLUSION:All the concentrations of levofloxacin at different times after dripping in aqueous humor exceeded the minimum inhibitory concentration for 90%(MIC90)of most bacterial pathogens.These results show that levofloxacin lactate eye-drops may be an effective antimicrobial agent for the treatment and prevention of intraocular infections as well as other ocular infections.

OBJECTIVE:To develop a preparation and quality control method for sinomenine gel.METHODS:Sinomenine gel was prepared with carpol971as base.TLC and UV were employed for identification of sinomenine.Sinomenine was deter?mined by RP-HPLC.RESULTS:The TLC identification was highly specific and the spots were clear.Recovery was99.6%?1.3%.CONCLUSION:This paper provides a rapid,convenient and accurate method which is suitable for preparation and quality control for sinomenine gel.

The prescription composition rules and special features of compound anti-influenza preparationS made from Chinese and western medicines are explored in this paper. The problems in the prescription composition rules are also discussed.