Objective To study the related key targets and main related signaling pathways of American ginseng in the treatment of acute liver injury by network pharmacology.Methods The main chemical components of American ginseng were found by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.The molecular formula of the components was obtained by Pubchem.The related target genes were obtained by SwissTargetPrediction,and the related targets of acute liver injury were collected by GeneCards database.Venny2.1 was used to obtain the intersection targets of drugs and diseases.The protein-protein interaction network was constructed by STRING online database and visualized by Cytoscape 3.7.1 software.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on the David website.Results Through data analysis,the research group obtained 10 effective components of American ginseng,330 drug-related targets,7 795 acute liver injury disease-related targets,and 291 drug-disease intersection targets.The treatment of acute liver injury by American ginseng mainly played a role through 216 biological processes,involving 30 cell compositions,44 molecular functions,and 116 signaling pathways.Conclusion American ginseng mainly treats acute liver injury by regulating key proteins such as mitogen-activated protein kinase 3(MAPK3),vascular endothelial growth factor A(VEGFA),heat shock protein 90AA1(HSP90AA1),Caspase-3,signal transducer and activator of transcription 3(STAT3),and intervening PI3K-Akt signaling pathway,cancer pathway,MAPK signaling pathway and other signaling pathways.

During decidualization, lactic acid is produced and accumulated in large amounts, becoming a prominent feature of the decidual microenvironment. Lactic acid not only serves as a key product in metabolic pathways, participating in rapid energy generation and conversion, but also influences cellular functional states by regulating the acid-base balance of the microenvironment. Furthermore, as a signaling molecule, lactic acid plays a central role in regulating decidual immune metabolism, promoting decidual angiogenesis, and facilitating trophoblast invasion, all of which are crucial for embryo implantation. In recent years, the role of lactic acid in epigenetics has also gradually emerged, with lactylation modifications involved in regulating gene expression and maintaining the homeostasis of the decidual microenvironment. This article will delve into the specific roles of lactic acid in the decidual microenvironment, aiming to provide new perspectives and theoretical foundations for the study of pregnancy-related diseases.

During decidualization, lactic acid is produced and accumulated in large amounts, becoming a prominent feature of the decidual microenvironment. Lactic acid not only serves as a key product in metabolic pathways, participating in rapid energy generation and conversion, but also influences cellular functional states by regulating the acid-base balance of the microenvironment. Furthermore, as a signaling molecule, lactic acid plays a central role in regulating decidual immune metabolism, promoting decidual angiogenesis, and facilitating trophoblast invasion, all of which are crucial for embryo implantation. In recent years, the role of lactic acid in epigenetics has also gradually emerged, with lactylation modifications involved in regulating gene expression and maintaining the homeostasis of the decidual microenvironment. This article will delve into the specific roles of lactic acid in the decidual microenvironment, aiming to provide new perspectives and theoretical foundations for the study of pregnancy-related diseases.

Objective To study the related key targets and main related signaling pathways of American ginseng in the treatment of acute liver injury by network pharmacology.Methods The main chemical components of American ginseng were found by the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.The molecular formula of the components was obtained by Pubchem.The related target genes were obtained by SwissTargetPrediction,and the related targets of acute liver injury were collected by GeneCards database.Venny2.1 was used to obtain the intersection targets of drugs and diseases.The protein-protein interaction network was constructed by STRING online database and visualized by Cytoscape 3.7.1 software.GO functional enrichment analysis and KEGG pathway enrichment analysis were performed on the David website.Results Through data analysis,the research group obtained 10 effective components of American ginseng,330 drug-related targets,7 795 acute liver injury disease-related targets,and 291 drug-disease intersection targets.The treatment of acute liver injury by American ginseng mainly played a role through 216 biological processes,involving 30 cell compositions,44 molecular functions,and 116 signaling pathways.Conclusion American ginseng mainly treats acute liver injury by regulating key proteins such as mitogen-activated protein kinase 3(MAPK3),vascular endothelial growth factor A(VEGFA),heat shock protein 90AA1(HSP90AA1),Caspase-3,signal transducer and activator of transcription 3(STAT3),and intervening PI3K-Akt signaling pathway,cancer pathway,MAPK signaling pathway and other signaling pathways.

Objective To acquire,evaluate and integrate the best evidence of perioperative exercise interventions in patients with liver cancer and provide evidence-based references for clinical medical staff.Methods Following the"6S"Evidence Resource Pyramid model,literatures in perioperative exercise interventions published between January 2010 and June 2022 were retrieved from various databases,including BMJ Best Practice,UpToDate,Guidelines International Network,National Guideline Clearinghouse,National Institute for Health and Clinical Excellence,Scottish Intercollegiate Guidelines Network,Medlive,Cochrane Library,JBI,Web of Science,PubMed,Embase,CINAHL,CNKI,SinoMed,Wanfang Data,American Cancer Society,American College of Sports Medicine and International Liver Cancer Association from January 2010 to June 2022.Two researchers evaluated the quality of the retrieved literatures and extracted evidences that met the inclusion criteria.Results A total of 22 articles were included,yielding 26 pieces of evidence across seven themes:the necessity of exercise,evaluation before exercise,preoperative exercise program,postoperative exercise program,exercise monitoring,health education and effect evaluation.Conclusions This study provides a summary of the best evidence regarding perioperative exercise interventions in the patients with liver cancer.The findings offer valuable references for clinical healthcare providers to deliver evidence-based care for the patients with liver cancer.

Glucose transporters (GLUTs) are widely expressed in the endometrium, mediate glucose uptake, and regulate energy metabolism of endometrial stromal cells, as well as decidual immune metabolism and other related processes. GLUTs also interact with important signaling pathways during decidualization, affecting embryo implantation. In this paper, the aspects of GLUTs expression and mechanism during decidualization are reviewed in order to provide a theoretical basis for the prevention and treatment of infertility and pregnancy-related diseases.

Glucose transporters (GLUTs) are widely expressed in the endometrium, mediate glucose uptake, and regulate energy metabolism of endometrial stromal cells, as well as decidual immune metabolism and other related processes. GLUTs also interact with important signaling pathways during decidualization, affecting embryo implantation. In this paper, the aspects of GLUTs expression and mechanism during decidualization are reviewed in order to provide a theoretical basis for the prevention and treatment of infertility and pregnancy-related diseases.

Pulmonary blast injury has become the main type of trauma in modern warfare, characterized by externally mild injuries but internally severe injuries, rapid disease progression, and a high rate of early death. The injury is complicated in clinical practice, often with multiple and compound injuries. Currently, there is a lack of effective protective materials, accurate injury detection instrument and portable monitoring and transportation equipment, standardized clinical treatment guidelines in various medical centers, and evidence-based guidelines at home and abroad, resulting in a high mortality in clinlcal practice. Therefore, the Trauma Branch of Chinese Medical Association and the Editorial Committee of Chinese Journal of Trauma organized military and civilian experts in related fields such as thoracic surgery and traumatic surgery to jointly develop the Clinical treatment guideline for pulmonary blast injury ( version 2023) by combining evidence for effectiveness and clinical first-line treatment experience. This guideline provided 16 recommended opinions surrounding definition, characteristics, pre-hospital diagnosis and treatment, and in-hospital treatment of pulmonary blast injury, hoping to provide a basis for the clinical treatment in hospitals at different levels.

The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies. At present, a variety of small molecule PROTACs have entered the clinical trial. However, as small molecule PROTACs flourish, non-small molecule PROTACs (NSM-PROTACs) such as peptide PROTACs, nucleic acid PROTACs and antibody PROTACs have also advanced considerably over recent years, exhibiting the unique characters beyond the small molecule PROTACs. Here, we briefly introduce the types of NSM-PROTACs, describe the advantages of NSM-PROTACs, and summarize the development of NSM-PROTACs so far in detail. We hope this article could not only provide useful insights into NSM-PROTACs, but also expand the research interest of NSM-PROTACs.

COVID-19 ; China/epidemiology* ; Disease Outbreaks ; Humans ; SARS-CoV-2