Objective To investigate the predictive value of serum interleukin-17(IL-17)and soluble hemoglobin scavenger receptor 163(sCD163)for early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery.Methods From June 2022 to June 2024,80 colorectal cancer patients who underwent laparoscopic surgery were selected as the study subjects.Patients were subdivided into an anastomotic leakage group(17 cases)and a non-anastomotic leakage group(63 cases)according to whether an anastomotic leakage occurred within 7 d postoperatively.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the levels of serum IL-17 and sCD163 in patients on preoperative day 1,postoperative day 1,postoperative day 3,postoperative day 5,and postoperative day 7.The clinical data of the two groups were compared.Multivariate Logistic regression was applied to analyze the influencing factors of early anastomotic leakage in colorectal cancer patients after laparoscopic surgery.The receiver operating characteristic curve(ROC curve)was applied to analyze the predictive value of serum IL-17 and sCD163 levels for early anastomotic leakage in colorectal cancer patients after laparoscopic surgery.Results The percentage of distance between tumor and anus＜7 cm was higher in the anastomotic leakage group than that in the non-anastomotic leakage group,and the amount of drainage was more than that in the non-anastomotic leakage group at 7 d postoperatively,the differences were statistically significant(P＜0.05).There were statistically significant differences in the levels of serum IL-17 and sCD163 between the two groups of patients at different time points,as well as in time and interaction effects(P＜0.05).Distance between tumor and anus＜7 cm(O R=3.176,95％CI:1.128～8.940),serum IL-17 level ≥ 43.95 pg/mL at 3 d postoperatively(O R=2.145,95％CI:1.281～3.592),and serum sCD163 level ≥ 81.02 pg/mL at 5d postoperatively(OR=1.852,95％CI:1.225～2.801)were the risk factors of early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery(P＜0.05).The area under the curve(AUC)of the combination of serum IL-17 and sCD163 in predicting early anastomotic leakage in colorectal cancer patients after laparoscopic surgery was 0.923,which was superior to the single diagnosis of serum IL-17 and sCD163(Zcombination-IL-17=2.77,Zcombination-sCD163=2.11,P＜0.05).Conclusion Serum IL-17 and sCD163 levels are elevated in colorectal cancer patients with early anastomotic leakage after laparoscopic surgery.The combined detection of the two has certain clinical value in predicting early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery.

Objective To investigate the predictive value of serum interleukin-17(IL-17)and soluble hemoglobin scavenger receptor 163(sCD163)for early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery.Methods From June 2022 to June 2024,80 colorectal cancer patients who underwent laparoscopic surgery were selected as the study subjects.Patients were subdivided into an anastomotic leakage group(17 cases)and a non-anastomotic leakage group(63 cases)according to whether an anastomotic leakage occurred within 7 d postoperatively.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the levels of serum IL-17 and sCD163 in patients on preoperative day 1,postoperative day 1,postoperative day 3,postoperative day 5,and postoperative day 7.The clinical data of the two groups were compared.Multivariate Logistic regression was applied to analyze the influencing factors of early anastomotic leakage in colorectal cancer patients after laparoscopic surgery.The receiver operating characteristic curve(ROC curve)was applied to analyze the predictive value of serum IL-17 and sCD163 levels for early anastomotic leakage in colorectal cancer patients after laparoscopic surgery.Results The percentage of distance between tumor and anus＜7 cm was higher in the anastomotic leakage group than that in the non-anastomotic leakage group,and the amount of drainage was more than that in the non-anastomotic leakage group at 7 d postoperatively,the differences were statistically significant(P＜0.05).There were statistically significant differences in the levels of serum IL-17 and sCD163 between the two groups of patients at different time points,as well as in time and interaction effects(P＜0.05).Distance between tumor and anus＜7 cm(O R=3.176,95％CI:1.128～8.940),serum IL-17 level ≥ 43.95 pg/mL at 3 d postoperatively(O R=2.145,95％CI:1.281～3.592),and serum sCD163 level ≥ 81.02 pg/mL at 5d postoperatively(OR=1.852,95％CI:1.225～2.801)were the risk factors of early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery(P＜0.05).The area under the curve(AUC)of the combination of serum IL-17 and sCD163 in predicting early anastomotic leakage in colorectal cancer patients after laparoscopic surgery was 0.923,which was superior to the single diagnosis of serum IL-17 and sCD163(Zcombination-IL-17=2.77,Zcombination-sCD163=2.11,P＜0.05).Conclusion Serum IL-17 and sCD163 levels are elevated in colorectal cancer patients with early anastomotic leakage after laparoscopic surgery.The combined detection of the two has certain clinical value in predicting early anastomotic leakage in patients with colorectal cancer after laparoscopic surgery.

Aim: To study the therapeutic effects of ZK_(14), a novel nitric oxide donor, on hepatic fibrosis in rats. Methods: Rats were injected intraperitoneally with CCl_4 and induced to hepatic fibrosis, followed by intra-gasrtic administration with high dose of 20 mg/kg and low dose of 10 mg/kg of ZK_(14) for 4 weeks. The effects were evaluated in the content of nitric oxide of serum and nitric oxide synthases of liver, in serum levels of the hepatic functions indices and hepatic fibrotic index and in liver histopathology. Results: The biochemical indices and pathology grade were effectively improved in the group of ZK_(14) 20 mg/kg, and liver function was also effectively protected in this group. Conclusion: ZK_(14), a novel nitric oxide donating biphenyldicarboxylate derivative, showed preferable therapeutic effects on hepatic fibrosis of rats induced with CC14, and it may be of potential value in the treatment of hepatic fibrosis.

OBJECTIVE: To investigate the information acquired through the four diagnostic methods of traditional Chinese medicine in patients with bronchial asthma, and to classify the syndrome types. METHODS: Four hundred and thirty patients with bronchial asthma were randomly investigated. The information acquired through the four diagnostic methods was recorded and the database was established by Amos software, and then the data were analyzed by confirmatory factor analysis (CFA). RESULTS: After analyzing the data with 4 factors, 5 factors and 6 factors, we found that the results of CFA with 6 factors were in accordance with clinical practical experience. CONCLUSION: According to the results of CFA with 6 factors and with the standard regression coefficient 0.4 as primary and secondary critical points, the syndromes in patients with bronchial asthma can be classified into 5 types, which are syndromes of cold fluid retained in lung, phlegm-heat obstructing lung, wind-phlegm blocking lung, qi deficiency of lung and kidney and qi deficiency of spleen.