Background Pneumoconiosis, a group of lung disease caused by long-term inhalation of occupational dust, features progressive development, irreversibility, and a high incidence of complications. It seriously endangers the health of the occupational population and exacerbates the socioeconomic burden. Objective To understand the development and major research themes of artificial intelligence research concerning pneumoconiosis and its complications. Methods Relevant academic papers before 2024-10-01 were retrieved from China National Knowledge Infrastructure and Web of Science, and analyzed separately according to the author, institutions, and keywords, then visualized with Citespace, the Bibliometrix package in R, and VOSviewer software. Results This study included 1068 articles (208 Chinese and 860 English). The results showed that artificial intelligence application in pneumoconiosis and its complications has seen explosive growth in the past five years. Institutions were mainly concentrated in universities and their affiliated medical units. Identified research hotspots included medical image recognition and analysis, auxiliary diagnosis, and risk prediction. Keywords like artificial intelligence, tuberculosis, deep learning, chronic obstructive pulmonary disease, and machine learning showed high centrality. Conclusion As computer technology advances, the use of artificial intelligence in addressing pneumoconiosis and its related complications is steadily expanding. Its research perspective has gradually expanded from simple disease prediction to diversified fields such as image recognition and health monitoring. Early pneumoconiosis screening, auxiliary differential diagnosis, andhealth monitoring will be the focus of future research.

Objective To investigate the protective effect of Gynostemma pentaphyllum on memory of individuals rapidly ascending to high altitudes.Methods Twenty-one healthy subjects were randomly divided into a G.pentaphyllum food group(n=12)and a control group(n=9).The first group consumed G.pentaphyllum food for seven consecutive days while the control group received placebos.Both groups ascended from the plains to an altitude of 3600 m.Memory function was assessed using the matching memory and sequential memory tests of a cognitive evaluation system on day 1 and day 7 on the plains,and at 24 and 48 h after ascending to the high altitude.Scores of acute mountain sickness symptoms were also recorded.Results After 24 h of stay at the high altitude,the score of headache of the G.pentaphyllum food group was significantly lower than that of the control group(P＜0.05).Cognitive test results showed that the matching memory accuracy and sequential memory accuracy of the control group at 24 and 48 h were significantly lower than those on the plains(P＜0.05).In contrast,the G.pentaphyllum food group performed significantly better than the control group in these metrics(P＜0.05).Conclusion Regular consumption of G.pentaphyllum food can effectively alleviate headache symptoms in individuals rapidly ascending to high altitudes and mitigate the decline in working memory,short-term memory,and memory spans caused by acute hypoxic exposure.

Objective:To study investigates the current healthcare-seeking status of patients with pneumoconiosis at grassroots rehabilitation stations in Henan Province, analyzes their healthcare-seeking behaviors and influencing factors, and provides references for formulating relevant rehabilitation treatment and health management policies.Methods:In July 2024, a total of 492 cases of pneumoconiosis patients registered at 7 grassroots pneumoconiosis rehabilitation stations from July to December 2021 were selected. The "Healthcare-Seeking Behavior and Influencing Factors of Pneumoconiosis Patients" questionnaire was used to collect information through a combination of rehabilitation station consultations and household interviews. Data on medical insurance type, whether the employer had purchased work-related injury insurance, patient condition characteristics (years of dust exposure, pneumoconiosis stage, patient condition score) , and reasons for not visiting rehabilitation stations were gathered and statistically analyzed. Univariate analysis was conducted using the chi-square test and logistic regression analysis was used to identify the influencing factors of patients' medical-seeking behavior.Results:A total of 492 pneumoconiosis patients were registered in basic rehabilitation stations in Henan Province. Among them, 204 cases (41.5%) went to the rehabilitation station, In the past year, 288 cases (58.5%) did not visit. Patients with pneumoconiosis who have no income, whose employer has purchased work-related injury insurance, whose pneumoconiosis type is silicosis, and whose disease score is 15-20 points have a high rate of visits to rehabilitation stations ( OR=8.35, 95% CI: 4.40-15.84; OR=13.89, 95% CI: 7.69-25.08; OR=3.20, 95% CI: 1.18-8.68; OR=5.18, 95% CI: 2.04-13.14) . The top five reasons for the analysis of not visiting were: the self-induction symptoms lighter (58.7%, 169/288) , online consultation or telephone follow-up (17.0%, 49/288) , buying medicine in a drugstore (14.6%, 42/288) , thinking of seeing a doctor is useless, can not be cured (6.9%, 20/288) , medical expenses are high and cannot be reimbursed (6.3%, 18/288) . Conclusion:Economically disadvantaged silicosis patients with work-related injury insurance and severe conditions prefer seeking treatment at nearby rehabilitation stations. The main reasons for reluctance to seek medical care are low treatment demand and concerns over high costs. Greater attention should be paid to the demand of pneumoconiosis patients for "Internet+healthcare" services at grassroots-level rehabilitation stations.

Objective:To study investigates the current healthcare-seeking status of patients with pneumoconiosis at grassroots rehabilitation stations in Henan Province, analyzes their healthcare-seeking behaviors and influencing factors, and provides references for formulating relevant rehabilitation treatment and health management policies.Methods:In July 2024, a total of 492 cases of pneumoconiosis patients registered at 7 grassroots pneumoconiosis rehabilitation stations from July to December 2021 were selected. The "Healthcare-Seeking Behavior and Influencing Factors of Pneumoconiosis Patients" questionnaire was used to collect information through a combination of rehabilitation station consultations and household interviews. Data on medical insurance type, whether the employer had purchased work-related injury insurance, patient condition characteristics (years of dust exposure, pneumoconiosis stage, patient condition score) , and reasons for not visiting rehabilitation stations were gathered and statistically analyzed. Univariate analysis was conducted using the chi-square test and logistic regression analysis was used to identify the influencing factors of patients' medical-seeking behavior.Results:A total of 492 pneumoconiosis patients were registered in basic rehabilitation stations in Henan Province. Among them, 204 cases (41.5%) went to the rehabilitation station, In the past year, 288 cases (58.5%) did not visit. Patients with pneumoconiosis who have no income, whose employer has purchased work-related injury insurance, whose pneumoconiosis type is silicosis, and whose disease score is 15-20 points have a high rate of visits to rehabilitation stations ( OR=8.35, 95% CI: 4.40-15.84; OR=13.89, 95% CI: 7.69-25.08; OR=3.20, 95% CI: 1.18-8.68; OR=5.18, 95% CI: 2.04-13.14) . The top five reasons for the analysis of not visiting were: the self-induction symptoms lighter (58.7%, 169/288) , online consultation or telephone follow-up (17.0%, 49/288) , buying medicine in a drugstore (14.6%, 42/288) , thinking of seeing a doctor is useless, can not be cured (6.9%, 20/288) , medical expenses are high and cannot be reimbursed (6.3%, 18/288) . Conclusion:Economically disadvantaged silicosis patients with work-related injury insurance and severe conditions prefer seeking treatment at nearby rehabilitation stations. The main reasons for reluctance to seek medical care are low treatment demand and concerns over high costs. Greater attention should be paid to the demand of pneumoconiosis patients for "Internet+healthcare" services at grassroots-level rehabilitation stations.

Aldehyde dehydrogenase 2 (ALDH2) is one of important factors against from the damage under oxidative stress in human body. A high proportion of East Asians carry ALDH2 inactive mutation gene. There are many diseases closely related to ALDH2, such as cardiovascular diseases, neurodegenerative diseases and liver diseases. Recent studies also have found that ALDH2 is associated with ferroptosis. Therefore, ALDH2 has becoming a potential target for the treatment of the above related diseases. Several types of small molecule activators with potential value of clinical application have been reported. The research progress on the structure and function of ALDH2 , the relationship with human diseases and its activators were summarized in this paper.

OBJECTIVE To study the anti-ulcerative colitis(UC) effect of Sargentodoxae Caulis and explore its mechanism. METHODS The UC mice model induced by dextran sodium sulfate was used to evaluate the anti-UC effect of Sargentodoxae Caulis. The ingredients of Sargentodoxae Caulis were obtained according to the CNKI and PubMed website, component targets were screened by SwissTargetPrediction database, GEO gene chip was used to extract UC differential genes, then a network of "ingredients-targets-disease" of the Sargentodoxae Caulis was constructed. After screening the core targets, protein interaction and cluster analysis, biological process and pathway enrichment analysis were performed, and the reliability of network analysis was preliminarily verified by molecular docking and literatures. RESULTS Sargentodoxae Caulis could significantly improve the disease activity index score, colon shortening and colonic histopathological changes of UC mice, and had a good anti-UC effect. The network analysis found that the core components of the anti-UC of Sargentodoxae Caulis include (+)-Dihydroxyurearetic acid, Isorhaponigenin and Pinosylvin, and 63 core targets, such as EGFR, STAT1 and LCK, regulating PI3K-Akt signal pathway and cancer proteoglycan and other related signal pathways of immune anti-inflammatory and anti-cancer, and it could affect the biological processes such as amino acid modification, kinase activity regulation, cell reaction and oxidative stress to treat UC. Molecular docking and literature showed that the constructed network had high reliability. CONCLUSION Sargentodoxae Caulis has a good anti-UC effect, and its mechanism may be closely related to the regulation of intestinal immune inflammation and cell proliferation, differentiation and migration. It has the characteristics of multi-component, multi-target and multi-way.

Objective: To evaluate the utilization and influencing factors of whole lung lavage (WLL) for patients with pneumoconiosis. Methods: A total of 10 524 pneumoconiosis patients who sought medical treatment from 2018 to 2021 were selected as the research subjects using a combination of stratified random sampling and non-random sampling methods. The patients were from 27 provincial administrative regions of Chinese mainland (excluding Shanghai City, Tianjin City, Hainan Province and Tibet Autonomous Region). The effects of demographic and sociological characteristics, disease-related factors, and economic and social security status on WLL utilization were analyzed. Results: The WLL rate of pneumoconiosis patients was 17.8% (1 871/10 524). The main reason for promoting WLL in pneumoconiosis patients was “doctor's advice”, accounting for 65.4%； followed by “known-pneumoconiosis-patients had WLL” and “patient's recommendation”, accounting for 24.1% and 18.1%, respectively. Multivariate logistic regression analysis showed that age, body mass index, smoking index, education level, survey area, source of patients, current employment status, nature of dust-exposed unit, stage of pneumoconiosis, type of pneumoconiosis, pneumoconiosis symptoms (coughing up phlegm, chest pain, dyspnea, joint pain), contraindications to WLL (tuberculosis, pulmonary heart disease), family annual income, medical insurance for urban employees, proportion of medical insurance reimbursement, disability benefits, and social assistance were the influencing factors of WLL utilization in pneumoconiosis patients (all P<0.05). Conclusion: A large proportion of pneumoconiosis patients used WLL. The influencing factors of WLL utilization included demographic and sociological characteristics, disease-related factors, economic and social security status, and more. It is necessary to protect the interests of pneumoconiosis patients, strengthen occupational health education and health promotion for pneumoconiosis patients, standardize the use of WLL in medical institutions, and make rational use of WLL.

To revise GBZ 188 Technical Specification for Occupational Health Surveillance based on national laws, regulations, standards, specifications and legal documents of occupational disease, and combination with the actual situation in China. The main modifications are as follows: the occupational health surveillance for workers exposed to toluene (xylene may implement by reference), bromopropane, methyl iodide, ethylene oxide, chloroacetic acid, indium and its compounds, coal tar, coal tarasphalt, asphalt, β-naphthylamine, dust of metal and its compounds(tin, iron, antimony, barium and its compounds), hard metal dust, erionite dust, low temperature, laser, tick-borne encephalitis virus, Borrelia burgdorferi, and human immunodeficiency virus, for scraper or grind operators, and underground workers using squatting or kneeling position, crawling position, side-lying position, or shoulder position for a long period of time are included. The emergency health screening for workers exposed to arsenic, fluorine and its inorganic compounds, and acrylamide are included. The occupational medical examination (OME) for workers exposed to amino and nitro compounds of benzene, phosgene, monomethylamine, organic fluorine and dimethyl sulfate has been adjusted and made mandatory, with corresponding assessments required upon leaving the job. The special occupational health surveillance for workers exposed to mycobacterium tuberculosis and hepatitis virus is removed. The OME conclusion of reexamination is removed, and standardize recheck/additional inspection requirements. The optional items in OME performed before, during and after leaving post are removed, but the optional items in emergency medical examination are retained. Additional OME items are added. The Guideline for OME Summary Reports is added as informative appendix, and so on. The revised GBZ 188 Technical Specification for Occupational Health Surveillance is more scientific and practical.

Background::Patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis (PTB) and need particular attention. However, extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been reported in China since 1992. This study aimed to investigate the epidemiological characteristics of PTB in patients with pneumoconiosis based on its social determinants and risk factors in China.Methods::Based on the Commission on Social Determinants of Health (CSDH) framework, data were obtained from a questionnaire survey of patients with pneumoconiosis from China’s 27 provinces (autonomous regions, municipalities) from December 2017 to June 2021. By chi-square and multivariate logistic regression analyses, the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio (OR) and associated social determinants and risk factors. The population attributable fractions (PAFs) of significant risk factors were also calculated.Results::The prevalence of PTB in patients with pneumoconiosis ( n = 10,137) was 7.5% (95% confidence interval [CI]: 7.0-8.0%). Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB (OR = 3.30, 95% CI: 2.77-3.93), clinically diagnosed cases (OR = 3.25, 95% CI: 2.42-4.34), and northeastern regions (OR = 2.41, 95% CI: 1.76-3.31). In addition, lack of work-related injury insurance (WRII), being born in a rural area, being unemployed, living in western regions, household exposure to patients with PTB, smoking, being underweight, complications of pulmonary bullae or pneumothorax, hospitalization history, and former drinkers among the rural patients were also statistically significant risk factors. Being born in a rural area, lack of WRII and in-hospital exposure to patients with PTB had higher PAFs, which were 13.2% (95% CI: 7.9-18.5%), 12.5% (95% CI: 8.3-16.7%), and 11.6% (95% CI: 8.8-14.3%), respectively. Conclusion::The prevalence of PTB in pneumoconiosis remains high in China; it is basically in line with the CSDH models and has its characteristics.