Objective To explore the gender differences and the influence of varus and valgus deformities on distal femur rotational alignment in patients with knee osteoarthritis so as to provide reference for the distal femur rotational osteotomy in total knee arthroplasty(TKA).Methods CT data of 125 knees with osteoarthritis suitable for TKA(including 56 males and 69 females;78 varus knees and 47 valgus knees)were collected and received three-dimensional imaging reconstruction with Mimics software.We measured the posterior condylar angle(PCA),the angle between the anteroposterior axis and the surgical epicondylar axis(ASA),and the angle between the anteroposterior axis and the posterior condylar axis(APA).We also compared gender differences and the influences of varus-valgus deformities on distal femur rotational alignments.Results The PCA and ASA values of distal femur rotational alignments were(3.5±1.1)° vs.(2.8±1.2)°(P=0.001)and(90.6±3.4)° vs.(91.9±3.5)°(P=0.028)for males and females,with statistically differences between the genders.There was no statistically difference in APA between males and females(P=0.482).The PCA values of distal femur rotational alignment in varus and valgus knees were(3.6±1.1)° and(2.9±1.2)°,with a statistically difference between the two groups(P=0.001).There were no statistically differences in ASA or APA between varus and valgus knees(P＞0.05).Conclusion Gender and varus-valgus deformities of knee joint affect the distal femur rotational alignment.Distal femur rotational osteotomy angle should be determined according to the patient's CT imaging before TKA to reduce the errors caused by individual differences and improve the accuracy of the distal femur rotational alignment during TKA.

Peri-implant diseases are inflammatory diseases in the spectrum of oral diseases, which are caused by the dysbiosis of peri-implant flora and the imbalance between microorganism and host. Peri-implant diseases are divided into two types: peri-implant mucositis and peri-implantitis. The diagnostic definition of peri-implant mucositis is based on presence of peri-implant signs of inflammation (redness, swelling, line or drop of bleeding/suppuration following probing) and no additional bone loss following initial healing. The clinical definition of peri-implantitis is based on not only the presence of peri-implant signs of inflammation but also radiographic evidence of bone loss following initial healing. Peri-implant diseases, like periodontitis, have clear etiology, histopathological features, clinical manifestations, and current international consensus diagnostic criteria. This article provides an overview of the etiology, histopathological features, key points of examination and diagnosis, prevention and non-surgical treatment, and surgical treatment of peri-implant diseases. The aim is to raise the awareness of dentists, especially those who specialize in oral implantology and restoration, to have a concept of periodontal and implant health, master the basic theoretical knowledge and prevention and treatment methods of peri-implant diseases, and also inform patients to control plaque and maintain their oral health.

This study establishes a high-performance liquid chromatography (HPLC) method for the determination of acetate content in hemodialysis solutions and dialysis concentrates. In this study, Synergi Polar-RP column is utilized. Phosphate buffered saline (50 mmol/L, pH=2.5) is used as a mobile phase. The flow rate is 1.0 mL/min. The wavelength of detection is 212 nm. Results show that the linear relationship of acetate is good in the range of 0.1~20 mmol/L, r =0.999 9 and the spike recoveries are from 98.9%~99.5%, RSD<0.5% ( n=3). This method can easily and accurately determine the acetate content in hemodialysis solutions and dialysis concentrates, and can be applied to quality control in the production and use of such products.
Chromatography, High Pressure Liquid/methods* ; Acetates/analysis* ; Hemodialysis Solutions/analysis* ; Dialysis Solutions/analysis* ; Renal Dialysis

Kashin-Beck disease (KBD), a common joint disorder that can lead to joint deformities and restricted mobility, significantly affects patients' quality of life. Traditional conservative treatments have shown limited efficacy. With advancements in total ankle replacement prosthesis and the successive updates of mobile and fixed -bearing in ankle prosthesis, more and more clinical trial results indicate that ankle prosthesis replacement is expected to become a new approach for treating KBD. This article reviews the progress in ankle prosthesis and studies their clinical application potential in KBD management.

Peri-implant diseases are inflammatory diseases in the spectrum of oral diseases, which are caused by the dysbiosis of peri-implant flora and the imbalance between microorganism and host. Peri-implant diseases are divided into two types: peri-implant mucositis and peri-implantitis. The diagnostic definition of peri-implant mucositis is based on presence of peri-implant signs of inflammation (redness, swelling, line or drop of bleeding/suppuration following probing) and no additional bone loss following initial healing. The clinical definition of peri-implantitis is based on not only the presence of peri-implant signs of inflammation but also radiographic evidence of bone loss following initial healing. Peri-implant diseases, like periodontitis, have clear etiology, histopathological features, clinical manifestations, and current international consensus diagnostic criteria. This article provides an overview of the etiology, histopathological features, key points of examination and diagnosis, prevention and non-surgical treatment, and surgical treatment of peri-implant diseases. The aim is to raise the awareness of dentists, especially those who specialize in oral implantology and restoration, to have a concept of periodontal and implant health, master the basic theoretical knowledge and prevention and treatment methods of peri-implant diseases, and also inform patients to control plaque and maintain their oral health.

Objective To explore the gender differences and the influence of varus and valgus deformities on distal femur rotational alignment in patients with knee osteoarthritis so as to provide reference for the distal femur rotational osteotomy in total knee arthroplasty(TKA).Methods CT data of 125 knees with osteoarthritis suitable for TKA(including 56 males and 69 females;78 varus knees and 47 valgus knees)were collected and received three-dimensional imaging reconstruction with Mimics software.We measured the posterior condylar angle(PCA),the angle between the anteroposterior axis and the surgical epicondylar axis(ASA),and the angle between the anteroposterior axis and the posterior condylar axis(APA).We also compared gender differences and the influences of varus-valgus deformities on distal femur rotational alignments.Results The PCA and ASA values of distal femur rotational alignments were(3.5±1.1)° vs.(2.8±1.2)°(P=0.001)and(90.6±3.4)° vs.(91.9±3.5)°(P=0.028)for males and females,with statistically differences between the genders.There was no statistically difference in APA between males and females(P=0.482).The PCA values of distal femur rotational alignment in varus and valgus knees were(3.6±1.1)° and(2.9±1.2)°,with a statistically difference between the two groups(P=0.001).There were no statistically differences in ASA or APA between varus and valgus knees(P＞0.05).Conclusion Gender and varus-valgus deformities of knee joint affect the distal femur rotational alignment.Distal femur rotational osteotomy angle should be determined according to the patient's CT imaging before TKA to reduce the errors caused by individual differences and improve the accuracy of the distal femur rotational alignment during TKA.

Kashin-Beck disease (KBD), a common joint disorder that can lead to joint deformities and restricted mobility, significantly affects patients' quality of life. Traditional conservative treatments have shown limited efficacy. With advancements in total ankle replacement prosthesis and the successive updates of mobile and fixed -bearing in ankle prosthesis, more and more clinical trial results indicate that ankle prosthesis replacement is expected to become a new approach for treating KBD. This article reviews the progress in ankle prosthesis and studies their clinical application potential in KBD management.

Objective:To evaluate the correlation between peri-implant probing depth (PPD) and radiographic bone level (rBL) in implants with peri-implantitis.Methods:From January 2019 to December 2022, 24 patients with 30 implants who suffered from peri-implantitis at the Department of Periodontology, Peking University School and Hospital of Stomatology were included in the present research. SPSS 26.0 software was used to simple random sampling select 30 healthy implants from which with electronic examination records in Department of Periodontology, Peking University School and Hospital of Stomatology from January 2007 to June 2023 as the control group. On the premise of retaining the implant prosthesis, PPD (distance between pocket bottom and peri-implant soft tissue margin) was examined using a Williams periodontal probe with a light force (about 0.2 N), and a total of 4 sites were recorded for each implant. Periapical radiography and cone beam CT were applied to measure the rBL (distance between the reference point at the neck of the implant and the apical point of the bone defect) and the width of the bone defect (DW), and the type of the bone defect was recorded. The correlation and consistency between the diagnosis of PPD and rBL were analyzed.Results:PPD was significantly correlated with rBL in a total of 60 implants in 180 sites ( r=0.64, P<0.001). The chi-square test showed an 8.15-fold increase in the detection rate of PD≥6 mm at sites with rBL≥1 mm ( P<0.001). Multivariate logistic regression analysis showed that rBL was still statistically associated with PPD after adjustment for jaw position and examination position of implants. Take rBL <1 mm as reference, the odds ratios ( OR) of 1 mm≤rBL<2 mm, 2 mm≤rBL<3 mm and rBL≥3 mm group with PPD were 6.23 ( P=0.014), 2.77 ( P=0.183) and 10.87 ( P=0.001), respectively. Conclusions:There is a positive correlation between PPD and rBL in implants with peri-implantitis. PPD can be used as a clinical examination index to assist in estimating the level of peri-implant bone under the premise of retaining the prosthesis.

Objective Exploring CT observation of the occlusion site and recent prognosis characteristics of endovascular treatment in patients with acute vertebrobasilar artery occlusion.Methods A total of 140 patients with acute vertebrobasilar artery occlusion treated in our hospital from January 2019 to May 2022 were selected. According to the pathological mechanism， there were 98 cases of atherosclerosis （group A） and 42 cases of embolism （group B）. The clinical data， occlusion site， and prognosis of the two groups were compared using the t-test or χ2 test， and the differences in the clinical data of patients with different outcomes were analyzed. Receiver operating characteristic （ROC） curves were used to determine the value of the National Institutes of Health Stroke Scale （NIHSS） score and the Basilar Artery on Computed Tomography Angiography （BATMAN） score for predicting poor prognosis.Results There were no significant differences between group A and group B in sex， age， the body mass index， hypertension，diabetes，history of stroke， time from onset to admission，NIHSS score， and BATMAN score （P＞0.05）. The occlusion rates of the vertebral artery V4 segment and the middle basilar artery in group A were 41.84% and 33.67% respectively， which were significantly higher than those in group B （P＜0.05）. The proportion of upper basilar artery occlusion in group B was 59.52%， which was significantly higher than that in group A （P＜0.05）. The ischemic penumbra volume and infarct core volume in group A were （46.64±15.44） ml and （20.10±9.92）ml， respectively， which were significantly lower than those in group B（P＜0.05）. Patients with a poor prognosis had a significantly higher NIHSS score（24.41±2.09） points and a significantly lower BATMAN score （3.61±0.72） points than patients with a good prognosis（P＜0.05）. For NIHSS score and BATMAN score predicting a poor prognosis，the areas under the ROC curves were 0.893 and 0.902，the cut-off values were 22 and 5，the sensitivity values were 86.60% and 92.70%，and the sensitivity values were 86.20% and 77.60%，respectively.Conclusion Patients with acute vertebrobasilar artery occlusion caused by intracranial atherosclerosis and embolism differ significantly in the occlusion site， but with no significant difference in the prognosis of patients. The NIHSS score and BATMAN score have certain application value in predicting the prognosis of patients with acute vertebrobasilar artery occlusion.
Embolism ; Prognosis

Objective:To analyze the failure patterns and survival after stereotactic body radiotherapy (SBRT) in patients with T 1-2N 0M 0 non-small cell lung carcinoma (NSCLC). Methods:Clinical data of early-stage NSCLC patients who received SBRT at Zhejiang Cancer Hospital from January 2012 to September 2018 were retrospectively analyzed. The primary observed endpoint was the pattern of disease progression, which was divided into intra-field recurrence, regional lymph node recurrence and distant metastasis. Overall survival (OS) and progression-free survival (PFS) were calculated by Kaplan-Meier method. Univariate analysis was conducted by log-rank test, and multivariate analysis was performed by Cox's model.Results:A total of 147 patients with 156 lesions were included. The median follow-up time was 44.0 months (16.5-95.5 months). A total of 57 patients (38.8%) progressed: 14 patients (24.5%) had recurrence with the 1-, 3-, and 5-year local recurrence rates of 2.0%, 10.9%, and 14.3%, respectively; 36 patients (63.2%) had Distant metastasis with the 1-, 3- and 5-year distant metastasis rates of 12.2%, 22.4% and 28.6%, respectively; and 7 patients (12.3%) had recurrence complicated with distant metastasis. The 3-, 5- and 7-year OS rates were 80.5%, 64.2% and 49.9% for all patients, respectively. The median OS was 78.4 months. The 3-, 5- and 7-year PFS rates were 64.8%,49.5% and 41.5%, with a median PFS of 57.9 months (95% CI: 42.3-73.5 months). Univariate and multivariate analyses showed that biologically equivalent dose and age were the factors affecting the efficacy of SBRT (both P<0.05). Conclusion:Distant metastasis is the main failure pattern in patients with T 1-2N 0M 0 NSCLC after SBRT. High-risk population should be selected for further systematic treatment to improve the efficacy.