The incidence of early-onset gastric cancer (EOGC) is consistently increasing, and its etiology is notably complex. This increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer (LOGC), including genetic predispositions, dietary factors, gastric microbiota dysbiosis, and screening of high-risk cases. These factors collectively contribute to the onset of cancer. EOGC significantly differs from LOGC in terms of clinicopathological and molecular characteristics. Moreover, multiple differences in prognosis and clinical management also exist. This study aimed to systematically review the latest research advancements in the epidemiological characteristics, etiological factors, clinicopathological and molecular features, prognosis, and treatment modalities of EOGC.

Objective To provide alternative delivery methods of novel oral antitumor drugs for patients with dysphagia.Methods The retrieval range was determined according to the"Guidelines for Clinical Application of Novel Antitumor Drugs(2022 edition)".By consulting the instructions and searching databases such as PubMed,Micromedex,UpToDate,etc.,the preparation,stability,storage,and related clinical information of temporary liquid drug formulations were obtained.Results Seventy novel oral anticancer drugs were included in the literature search.Thirty-three drugs had relevant literature or data supporting alternative administration methods,only eight had information on alternative administration in the instructions,and the level of evidence for other drugs varied.Conclusion The evidence levels were low for most temporary liquid formulations,and medical teams should fully consider the advantages and disadvantages of using these products outside the instructions and use them with caution.

Objective To observe the value of preoperative CT radiomics models for predicting composition of in vivo urinary calculi.Methods Totally 543 urolithiasis patients were retrospectively enrolled and divided into calcium oxalate monohydrate stone group(group A,n=373),anhydrous uric acid stone group(group B,n=86),carbonate apatite group(group C,n=30),ammonium urate stone group(group D,n=28)and ammonium magnesium phosphate hexahydrate stone group(group E,n=26)according to the composition of calculi,also divided into training set and test set at the ratio of 7:3.Radiomics features were extracted and screened based on plain CT images of urinary system.Five binary task models(model A-E corresponding to group A-E)and a quinary task model were constructed using least absolute shrinkage and selection operator algorithm for predicting the composition of calculi in vivo.Then receiver operating characteristic curves were drawn,and the area under the curves(AUC)were calculated to evaluate the predictive efficacy of binary task models,while the accuracy,precision,recall and F1 score were used to evaluate the predictive efficacy of the quinary task model.Results All binary task models had good efficacy for predicting the composition of urinary calculi in vivo,with AUC of 0.860-0.948 in training set and of 0.856-0.933 in test set.The accuracy,precision,recall and F1 score of the quinary task model for predicting the composition of in vivo urinary calculi was 82.25％,83.79％,46.23％and 0.596 in training set,respectively,while was 80.63％,75.26％,43.48％and 0.551 in test set,respectively.Conclusion Binary task radiomics models based on preoperative plain CT had good efficacy for predicting the composition of in vivo urinary calculi,while the quinary task radiomics model had high accuracy but relatively poor stability.

Objective: To explore the effect of different miniscrew placement heights on the distribution of biological forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization, to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments. Methods: Mimics, GeomagicStudio 2017, SolidWorks 2016, and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the following six working conditions: working condition 1 was the control group without miniscrews; working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm, 7 mm, 4 mm, and 1 mm from the top of the alveolar crest, respectively; working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane. Results: On the sagittal axis, miniscrew anchorage caused distal displacement of all teeth. Compared to the control group, in the miniscrew group, the displacement of the anterior molars exceeded that of the second molars. On the vertical axis, the result in the control group was similar to backward bending; the results in the miniscrew groups resembled the effect of a lever, lowering the lateral incisors and canines and raising the central incisors and first premolars. On the coronal axis, the second premolars and the first molars showed lingual displacement in the control group, and only the premolars and first molars showed lingual displacementin the miniscrew groups. The canines were the teeth that were most strongly affected by the change in miniscrew placement height. Conclusion The higher the miniscrew position is, the stronger the protective effect on the anterior anchorage. According to the miniscrew placement height, the mandibular arch should be properly narrowed, the central incisors and first premolars should be lowered, and the lateral incisors and canines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.

Objective To explore the effect of different miniscrew placement heights on the distribution of biologi-cal forces produced by clear aligner combined with intramaxillary traction for mandibular molar distalization,to identify the miniscrew location that is conducive to the protection of lower anterior tooth anchorage and to provide a reference that can be used when designing clinical treatments.Methods Mimics,GeomagicStudio 2017,SolidWorks 2016,and Ansys workbench were used to establish finite element analysis models and perform mechanical analysis under the fol-lowing six working conditions:working condition 1 was the control group without miniscrews;working conditions 2 to 5 had miniscrew in the buccal bone cortex between the first and second molars of the lower jaw 10 mm,7 mm,4 mm,and 1 mm from the top of the alveolar crest,respectively;working condition 6 had the miniscrew in the center of the buccal tongue at the anterior edge of the ascending branch of the lower jaw 5 mm above the occlusal plane.Results On the sagittal axis,miniscrew anchorage caused distal displacement of all teeth.Compared to the control group,in the miniscrew group,the displacement of the anterior molars exceeded that of the second molars.On the vertical axis,the result in the control group was similar to backward bending;the results in the miniscrew groups resembled the effect of a lever,lowering the lateral incisors and canines and raising the central incisors and first premolars.On the coronal ax-is,the second premolars and the first molars showed lingual displacement in the control group,and only the premolars and first molars showed lingual displacementin the miniscrew groups.The canines were the teeth that were most strong-ly affected by the change in miniscrew placement height.Conclusion The higher the miniscrew position is,the stron-ger the protective effect on the anterior anchorage.According to the miniscrew placement height,the mandibular arch should be properly narrowed,the central incisors and first premolars should be lowered,and the lateral incisors and ca-nines should be raised when designing clinical treatments.