1.Report of two cases of Clostridium perfringens infection leading to lethal intravascular hemolysis
Wenqin ZHANG ; Jinjing TIAN ; Qingyue LIU ; Yingchao LIU
Chinese Journal of Laboratory Medicine 2025;48(11):1465-1469
Case 1 A 68-year-old male patient presented with poor appetite persisting for over 2 months and had been diagnosed with liver cancer 7 days prior. He was admitted to Liaocheng Second People′s Hospital on October 17, 2017. On October 18, 2017, at 8:00, the patient underwent transcatheter arterial chemoembolization under local anesthesia. At 17:30, the patient developed a fever. At 20:00, "port wine-colored" urine was noted during catheterization, prompting transfer to the intensive care unit (ICU) for enhanced treatment. Case 2 A 67-year-old male patient with a previous diagnosis of hilar cholangiocarcinoma presented to the Emergency Department of Liaocheng Second People′s Hospital at 17:40 on March 25, 2025, due to "unconsciousness for one hour". Routine blood testing revealed significantly decreased white blood cells, red blood cells, and platelets. Considering the critical condition, the patient was transferred to the ICU. At 19:30, "port wine-colored" urine was observed in the urinary catheter. Both cases showed evident signs of hemolysis in blood samples, rapid disease progression, with fatal outcomes occurring within a short period. Blood cultures from both patients signaled positive in anaerobic bottles. Identification using the bioMérieux VITEK 2 COMPACT ANC card confirmed Clostridium perfringens. Bloodstream infections caused by Clostridium perfringens leading to such severe intravascular hemolysis are rare. The disease course is notoriously aggressive. In clinical practice, early recognition of this infection is paramount.
2.Diagnostic value of conventional ultrasound-based radiomics models in pathological subtyping of renal cell carcinoma
Jinhui LIU ; Guiwu CHEN ; Wenqin LIU ; Ting LI ; Tongxin ZHANG ; Xiaoling LENG
Chinese Journal of Ultrasonography 2025;34(5):416-425
Objective:To investigate the diagnostic value of different conventional ultrasound-based radiomics models and their combination with clinical ultrasound features in the pathological subtyping of renal cell carcinoma.Methods:Retrospective data from 286 patients diagnosed with renal cell carcinoma by pathology at the Tenth Affiliated Hospital of Southern Medical University between May 1,2017 and June 7,2024 were collected. Among the 286 patients,203 were clear cell carcinoma,44 were papillary renal cell carcinoma,and 39 were chromophobe renal cell carcinoma. The patients were randomly divided into a training group(201 cases)and a validation group(85 cases)in a ratio of 7 to 3. Regions of interest(ROI)were delineated on conventional ultrasound images,and the radiomics features were extracted. Feature selection was performed using Student's t-test,Pearson correlation,and the least absolute shrinkage and selection operator(LASSO). Six different machine learning methods included category gradient boosting(CatBoost),light gradient boosting machine(LightGBM),Logistic regression(LR),random forest(RF),support vector machine(SVM)and extreme gradient boosting(XGBoost)were used to establish radiomics models. Weight balancing was applied to correct for sample imbalance,and an imaging genomics model was constructed after balancing the samples. Independent predictors of renal cell carcinoma subtyping were selected from clinical ultrasound features using univariate and multivariate logistic regression analyses,and a clinical imaging model was constructed. The best-performing radiomics model was combined with the clinical independent predictors to construct a combined model. Receiver operating characteristic curves and the obuchowski index were plotted to evaluate model performance. Results:Among the radiomics models,the model constructed using Random Forest(RS RF)after balancing the samples exhibited the best predictive performance,with area under the curve(AUCs)of 0.918(micro-average ROC)and 0.903(macro-average ROC),and the obuchowski index was 0.885 in the validation group. The long and short axes of ultrasound image tumor masses were used as imaging independent predictors to construct a clinical imaging model. In the validation group,the AUCs of the clinical model were 0.886(micro-average ROC)and 0.606(macro-average ROC),and the obuchowski index was 0.569. The combined model achieved AUCs of 0.888(micro-average ROC)and 0.967(macro-average ROC),with an obuchowski index of 0.933,outperforming any single model. Conclusions:The combination of conventional ultrasound-based radiomics models with clinical ultrasound features demonstrates high diagnostic value in differentiating clear cell carcinoma,papillary renal cell carcinoma,and chromophobe renal cell carcinoma. It may serve as an auxiliary tool for providing timely and effective clinical guidance.
3.Practice and reflection on building the"party-building+health science popularization"model in public hospitals
Wenqin LIU ; Yangxia OU ; Yi REN ; Xinrui WANG ; Weiyin LIN ; Rui HUANG ; Shiting FANG ; Yangliang YE ; Yang ZHANG ; Xinchen LIU ; Weijun HUANG
Modern Hospital 2025;25(7):1010-1012
This article explores the construction and practice of the"Party Building+Health Science Popularization"model,using the"Yixian Health Science Popularization Guangdong Tour"campaign conducted by Sun Yat-sen Memorial Hospital as a case study.The initiative has achieved remarkable results.Additionally,it summarizes innovative measures,as well as uni-versal and exemplary experiences,providing new insights and pathway recommendations for public hospitals to develop the"Party Building+Health Science Popularization"model.
4.Reflection on the use of red culture in university-affiliated hospitals to enhance the effectiveness of par-ty building work
Wenqin LIU ; Xia OUYANG ; Yanliang YE ; Rui HUANG ; Xincheng LIU ; Yang ZHANG
Modern Hospital 2025;25(1):34-37
Red culture is an important part of Chinese national culture and the most valuable spiritual wealth of the Chi-nese people.This article explores the necessity of using red culture to enhance the effectiveness of party building work in universi-ty-affiliated hospitals in the new era.It shares the main experiences of Sun Yat-sen Memorial Hospital,Zhongshan University,in learning from the spirit of the Gutian Conference to improve party building work.The article discusses how the integration of ideo-logical party building,practical innovation,and in-depth research has achieved certain results in party building work,providing references and basis for inspiring the vitality of grassroots party building work and innovating its content.
5.Practice and reflection on building the"party-building+health science popularization"model in public hospitals
Wenqin LIU ; Yangxia OU ; Yi REN ; Xinrui WANG ; Weiyin LIN ; Rui HUANG ; Shiting FANG ; Yangliang YE ; Yang ZHANG ; Xinchen LIU ; Weijun HUANG
Modern Hospital 2025;25(7):1010-1012
This article explores the construction and practice of the"Party Building+Health Science Popularization"model,using the"Yixian Health Science Popularization Guangdong Tour"campaign conducted by Sun Yat-sen Memorial Hospital as a case study.The initiative has achieved remarkable results.Additionally,it summarizes innovative measures,as well as uni-versal and exemplary experiences,providing new insights and pathway recommendations for public hospitals to develop the"Party Building+Health Science Popularization"model.
6.Reflection on the use of red culture in university-affiliated hospitals to enhance the effectiveness of par-ty building work
Wenqin LIU ; Xia OUYANG ; Yanliang YE ; Rui HUANG ; Xincheng LIU ; Yang ZHANG
Modern Hospital 2025;25(1):34-37
Red culture is an important part of Chinese national culture and the most valuable spiritual wealth of the Chi-nese people.This article explores the necessity of using red culture to enhance the effectiveness of party building work in universi-ty-affiliated hospitals in the new era.It shares the main experiences of Sun Yat-sen Memorial Hospital,Zhongshan University,in learning from the spirit of the Gutian Conference to improve party building work.The article discusses how the integration of ideo-logical party building,practical innovation,and in-depth research has achieved certain results in party building work,providing references and basis for inspiring the vitality of grassroots party building work and innovating its content.
7.Report of two cases of Clostridium perfringens infection leading to lethal intravascular hemolysis
Wenqin ZHANG ; Jinjing TIAN ; Qingyue LIU ; Yingchao LIU
Chinese Journal of Laboratory Medicine 2025;48(11):1465-1469
Case 1 A 68-year-old male patient presented with poor appetite persisting for over 2 months and had been diagnosed with liver cancer 7 days prior. He was admitted to Liaocheng Second People′s Hospital on October 17, 2017. On October 18, 2017, at 8:00, the patient underwent transcatheter arterial chemoembolization under local anesthesia. At 17:30, the patient developed a fever. At 20:00, "port wine-colored" urine was noted during catheterization, prompting transfer to the intensive care unit (ICU) for enhanced treatment. Case 2 A 67-year-old male patient with a previous diagnosis of hilar cholangiocarcinoma presented to the Emergency Department of Liaocheng Second People′s Hospital at 17:40 on March 25, 2025, due to "unconsciousness for one hour". Routine blood testing revealed significantly decreased white blood cells, red blood cells, and platelets. Considering the critical condition, the patient was transferred to the ICU. At 19:30, "port wine-colored" urine was observed in the urinary catheter. Both cases showed evident signs of hemolysis in blood samples, rapid disease progression, with fatal outcomes occurring within a short period. Blood cultures from both patients signaled positive in anaerobic bottles. Identification using the bioMérieux VITEK 2 COMPACT ANC card confirmed Clostridium perfringens. Bloodstream infections caused by Clostridium perfringens leading to such severe intravascular hemolysis are rare. The disease course is notoriously aggressive. In clinical practice, early recognition of this infection is paramount.
8.Diagnostic value of conventional ultrasound-based radiomics models in pathological subtyping of renal cell carcinoma
Jinhui LIU ; Guiwu CHEN ; Wenqin LIU ; Ting LI ; Tongxin ZHANG ; Xiaoling LENG
Chinese Journal of Ultrasonography 2025;34(5):416-425
Objective:To investigate the diagnostic value of different conventional ultrasound-based radiomics models and their combination with clinical ultrasound features in the pathological subtyping of renal cell carcinoma.Methods:Retrospective data from 286 patients diagnosed with renal cell carcinoma by pathology at the Tenth Affiliated Hospital of Southern Medical University between May 1,2017 and June 7,2024 were collected. Among the 286 patients,203 were clear cell carcinoma,44 were papillary renal cell carcinoma,and 39 were chromophobe renal cell carcinoma. The patients were randomly divided into a training group(201 cases)and a validation group(85 cases)in a ratio of 7 to 3. Regions of interest(ROI)were delineated on conventional ultrasound images,and the radiomics features were extracted. Feature selection was performed using Student's t-test,Pearson correlation,and the least absolute shrinkage and selection operator(LASSO). Six different machine learning methods included category gradient boosting(CatBoost),light gradient boosting machine(LightGBM),Logistic regression(LR),random forest(RF),support vector machine(SVM)and extreme gradient boosting(XGBoost)were used to establish radiomics models. Weight balancing was applied to correct for sample imbalance,and an imaging genomics model was constructed after balancing the samples. Independent predictors of renal cell carcinoma subtyping were selected from clinical ultrasound features using univariate and multivariate logistic regression analyses,and a clinical imaging model was constructed. The best-performing radiomics model was combined with the clinical independent predictors to construct a combined model. Receiver operating characteristic curves and the obuchowski index were plotted to evaluate model performance. Results:Among the radiomics models,the model constructed using Random Forest(RS RF)after balancing the samples exhibited the best predictive performance,with area under the curve(AUCs)of 0.918(micro-average ROC)and 0.903(macro-average ROC),and the obuchowski index was 0.885 in the validation group. The long and short axes of ultrasound image tumor masses were used as imaging independent predictors to construct a clinical imaging model. In the validation group,the AUCs of the clinical model were 0.886(micro-average ROC)and 0.606(macro-average ROC),and the obuchowski index was 0.569. The combined model achieved AUCs of 0.888(micro-average ROC)and 0.967(macro-average ROC),with an obuchowski index of 0.933,outperforming any single model. Conclusions:The combination of conventional ultrasound-based radiomics models with clinical ultrasound features demonstrates high diagnostic value in differentiating clear cell carcinoma,papillary renal cell carcinoma,and chromophobe renal cell carcinoma. It may serve as an auxiliary tool for providing timely and effective clinical guidance.
9.Establishment of a real-time quality control method for identifying random error in serum sodium ion based on artificial intel-ligence voting algorithm
Yuan LIU ; Hexiang ZHENG ; Zhiye XU ; Wenqin CHEN ; Hongyan SONG ; Yuxin CHEN
Chinese Journal of Clinical Laboratory Science 2024;42(10):772-777
Objective To establish a novel real-time quality control method for rapidly identifying the random error of sodium ion con-centration in serum using an artificial intelligence voting algorithm,and evaluate the relevant effectiveness of the model established on this basis.Methods A total of 144 754 test results of serum sodium ion rom the inpatients measured by Beckman AU5400 biochemis-try analyzer from January to May 2021 were obtained retrospectively from laboratory information system of the Department of Clinical La-boratory,Nanjing Drum Tower Hospital,and all the data were used as unbiased data for the current study.The random errors were arti-ficially introduced to generate the corresponding biased data set.Subsequently,the voting algorithm-based internal quality control model(ViQC)was established using the principles of the voting algorithm.The ViQC model and five classical PBRTQC(patient-based real-time quality control)algorithms were performed direct to each biased data.The analytical performance of the ViQC model was evaluated by using classification model criteria.The trimmed average number of patient samples until error detection(tANPed)was used to com-pare the clinical detection efficacy of the ViQC model with those of the five classical algorithms,and the error detection curves were plotted.Results Compare with all the classical algorithms,the ViQC model showed a false positive rate below 0.002 and achieved ac-curacy above 0.951 in detecting all the deviations.When the error factors were 1.5,2.5,and 3.0,the false positive rate of the ViQC model was zero.When the error factor was 2.5,its accuracy reached 0.979.Compared to the five classical PBRTQC algorithms,the ViQC model reduced the overall average tANPed by up to 34%and showed higher sensitivity for error detection.In addition,the ViQC model demonstrated the area under the ROC curve was as high as 0.989 at TEa on the test set,but the value of tANPed wasonly five.Conclusion We successfully established a real-time quality control model for the data of patients based on artificial intelligence algo-rithms,and its efficacy of clinical detection was superior to the traditional PBRTQC algorithms.
10.Strategies for enhancing the influence of major themed publicity in hospital Party building
Weiyin LIN ; Rui HUANG ; Wenqin LIU ; Yang ZHANG ; Yangxia OU ; Jianping LI ; Haiyan CHEN
Modern Hospital 2024;24(8):1168-1170,1174
This research aimed to explore strategies to enhance the influence of major themed publicity in hospital party building within several prominent tertiary public hospitals in China,including one in Beijing,one in Zhejiang and four in Guang-dong.An analysis of themed publicity initiatives over the past five years,particularly during pivotal party events and key thematic activities,was undertaken.This assessment included both offline events and the online media coverage through various integrated media platforms.The study aimed to offer development suggestions for hospitals to amplify the influence of their major themed publicity strategies for Party building.Currently,hospitals are placing increased emphasis on the strategic planning of major themed publicity for Party building.Innovation in content and promotional tactics,along with strengthened integration with main-stream media,is essential.Effective dissemination that elicits empathy and presents high-quality publicity materials is crucial for achieving optimal dissemination outcomes and further elevating the hospital's Party building influence.

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