LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS Neurofibromatosis (NF) is an autosomal dominant neurocutaneous disorder. The itchiness suffered by patients with NF is possibly caused by mast cells. However, transient receptor potential ankyrin 1 (TrpA1) and transient receptor potential vanilloid 1 (TrpV1) have been recently discovered as mediators of itchiness and pain in patients with NF. We reported a patient with NF, afflicted by neuropathic pain and itch, despite despite receiving conservative treatment. Herein, we provided the patient lignocaine infusion, which improved her pain and itch score by 50%. Additionally, her sleep quality, ability to perform housework and engagement in leisure activities were improved. This case report highlights the therapeutic value of lignocaine infusion when conservative treatment is ineffective for chronic neuropathic itch in patients with neurofibromatosis through suppressing TrpA1 and TrpV1.

ADDUCTOR CANAL AND SUPERIOR LATERAL GENICULAR NERVE INJECTIONS FOR GRADE 4 KNEE OSTEOARTHRITIS: A CASE REPORT This case report showcases the successful use of a combination of adductor canal (AC) and superior lateral genicular nerve (SLGN) injections in a patient with refractory knee pain caused by knee osteoarthritis (OA). A 73-year-old man with Kellgren and Lawrence (KL) Grade 3-4 of bilateral knee OA experienced debilitating chronic right knee pain and declined surgery intervention. He reported significant pain relief, which improved his ability to walk, after receiving a combination of AC and SLGN injections with a mixture of local anesthetic and steroids. This followed the unsuccessful provision of multiple analgesics and intraarticular injections. The pain-relieving effects persisted until his 2-month follow-up. Repeated injections were performed 4 months after his initial intervention, with the analgesic effect lasting for another 2 months. This case report suggests that the combination of AC and SLGN injections could be a viable treatment for patients with knee OA KL Grade 4 who are not candidates for surgery.