Gastric cancer remains a highly prevalent malignancy worldwide, with surgical resection currently constituting the cornerstone of treatment aimed at improving long-term patient survival. Owing to their notable advantages, including reduced surgical trauma and accelerated postoperative recovery, minimally invasive procedures are progressively supplanting conventional open surgery and have become the mainstream approach in gastric cancer management. Concurrently, the rapid advancement of artificial intelligence (AI) technologies has enabled real-time intraoperative monitoring of surgical scenes, thereby furnishing novel technical support for adjunctive decision-making, surgical navigation, and skill assessment during gastrectomy. This article provides a systematic review of the current status of AI applications in minimally invasive gastric cancer surgery, with a particular focus on research progress pertaining to instrument recognition, surgical phase identification, delineation of normal anatomical structures, detection of metastatic foci, and early warning of intraoperative adverse events. Furthermore, we discuss the potential value of AI in enhancing surgical efficiency, ensuring patient safety, and optimizing surgical education. On this basis, we further analyze the principal challenges and inherent risks confronting current AI systems, with the aim of informing future technological innovation and facilitating clinical translation.

In 2022， Hainan provincial government launched the project for the prevention and control of viral hepatitis with the goals of a hepatitis B screening rate of 90%， a diagnostic rate of 90%， and a treatment rate of 80% among people aged 18 years and above by the year 2025， and the main intervention measures include population-based prevention， case screening， antiviral therapy， and health management. As of December 31， 2024， a total of 6.875 million individuals in the general population had been screened for hepatitis B， with a screening rate of 95.6%. A total of 184 710 individuals with positive HBsAg were identified， among whom 156 772 were diagnosed through serological reexamination， resulting in a diagnostic rate of 84.9%. A total of 50 742 patients with chronic hepatitis B were identified， among whom 42 921 had hepatitis B-specific health records established for health management， with a file establishment rate of 84.6%. A total of 31 553 individuals received antiviral therapy， with a treatment rate of 62.2%. A total of 2.503 million individuals at a high risk of hepatitis C were screened， among whom 4 870 tested positive for HCV antibody and 3 858 underwent HCV RNA testing， resulting in a diagnostic rate of 79.2%， and 1 824 individuals with positive HCV RNA were identified， among whom 1 194 received antiviral therapy， with a treatment rate of 65.5%. In addition， 159 301 individuals with negative HBsAg and anti-HBs and an age of 20 — 40 years were inoculated with hepatitis B vaccine free of charge. Through the implementation of the project for the prevention and control of viral hepatitis， a large number of hepatitis patients have been identified， treated， and managed in the province within a short period of time， which significantly accelerates the efforts to eliminate the crisis of viral hepatitis.

Objective:To explore the direction of the association between smartphone multitasking behavior and comorbid symptoms of anxiety and depression (CAD) among college students.Methods:College students from one college located in Shanxi, Chongqing, and Shenzhen were selected between October and December 2021 using a multistage random cluster sampling method, and a follow-up visit was conducted in May 2022. The Assessment of Smartphone Multitasking for Adolescents, the Patient Health Questionnaire-9 Items, and the Generalized Anxiety Disorder Questionnaire-7 Items were used to assess the smartphone multitasking behaviors and CAD of college students. Multivariate logistic regression models were used to analyze the associations between smartphone multitasking behavior and CAD. Autoregressive cross-lagged models (ARCLM) were used to analyze the bidirectional associations between smartphone multitasking behavior and CAD.Results:A total of 953 college students were included in this study, including 323 (33.9%) males and 630 (66.1%) females, with an age of (18.89±1.33) years. The detection rates of CAD at baseline and follow-up were 25.5% and 27.5%, respectively. The mean of the total smartphone multitasking index at baseline was 2.11±0.48. The mean of smartphone and non-media activity multitasking index was 2.00±0.55. The mean of smartphone and other media activity multitasking index was 1.92±0.67. The mean of smartphone functional use multitasking index was 2.18±0.54. The multivariate logistic regression models showed that smartphone and non-media activity multitasking index ( OR=1.85, 95% CI: 1.39-2.45), smartphone and other media activity multitasking index ( OR=1.42, 95% CI: 1.10-1.83), and total smartphone multitasking index ( OR=1.66, 95% CI: 1.21-2.28) were positively associated with the risk of CAD among college students at baseline. The smartphone and non-media activity multitasking index ( OR=1.74,95% CI: 1.30-2.32), smartphone and other media activity multitasking index ( OR=1.37, 95% CI: 1.04-1.79) and total smartphone multitasking index ( OR=1.48, 95% CI: 1.06-2.06) were positively associated with the risk of CAD at follow-up. There was no statistical association between smartphone functional use multitasking index at baseline and CAD. The ARCLM showed that smartphone and non-media activity multitasking index ( β=0.974, P=0.029), smartphone and other media multitasking index ( β=0.798, P=0.003), and the total smartphone multitasking index ( β=1.379, P=0.011) at baseline could positively predict the risk of CAD at follow-up. The CAD at baseline could positively predict smartphone and other media multitasking index ( β=0.004, P=0.016) and smartphone functional use multitasking index at follow-up ( β=0.004, P=0.016). Conclusion:There is a bidirectional association between smartphone and other media activity multitasking and CAD among college students.

To further standardize the management of vaccination units, the Specifications for Vaccination (2023 version) proposes hierarchical management. However, guidelines for establishing, implementing, and evaluating such a framework remain underdeveloped. This paper systematically reviews the current status of hierarchical management in vaccination units, clarifies its feasibility and necessity, and proposes an implementation scheme.

Objective:To evaluate the risk of developing pulmonary tuberculosis (PTB) among individuals with latent tuberculosis infection (LTBI) in schools and the protective effect of tuberculosis preventive treatment (TPT).Methods:A retrospective cohort study was conducted to collect data on 15 school outbreaks that occurred in Guangdong Province from 2017 to 2021. Baseline information on tuberculin skin test (TST) or interferon-gamma release test (IGRA) was obtained during contact surveys, as well as baseline information such as TPT. The incidence of PTB between 2017 and 2022 was queried using the Chinese Center for Disease Control and Prevention Information System. Poisson regression analysis was used to compare the incidence risk of PTB in the LTBI population under different TST states at baseline. Current cases, new cases and all cases (the sum of the two) were used as dependent variables. Cox regression models were used to analyze various risk factors affecting the risk of PTB in the LTBI population and evaluate the protective effect of TPT.Results:A total of 6 550 contacts were included in this study, of which 409 received TPT. Within 0-3 months after baseline survey, 119 cases were diagnosed as current cases [19.4‰, 119/(6 550-409)]. A total of 17 221.65 person-years of follow-up were conducted, during which 71 new cases were diagnosed (4.1/1 000 person-years, 71/17 221.65). The incidence density of PTB was 47.7/1 000 person-years, 6.6/1 000 person-years, 1.4/1 000 person-years, and 0.9/1 000 person-years, respectively, in TST strong/IGRA positive, TST moderate positive, TST generally positive, and TST and IGRA negative populations. The difference in PTB incidence density was statistically significant [likelihood ratio test LRT=153.16, P<0.001]. TPT was performed for individuals with strong TST or IGRA positivity, and the protection rate could reach 93% ( HR=0.07, 95% CI: 0.02-0.23). Conclusion:After the outbreak of the school epidemic, individuals with strong TST/IGRA positivity have a higher risk of developing PTB in the future. Targeted implementation of TPT can achieve better protection effects. In addition, the risk of developing PTB in individuals with moderate TST positivity is also worth noting.

Metformin has been demonstrated to attenuate hyperglycaemia by modulating the gut microbiota. However, the mechanisms through which the microbiome mediates metformin monotherapy failure (MMF) are unclear. Herein, in a prospective clinical cohort study of newly diagnosed type 2 diabetes mellitus (T2DM) patients treated with metformin monotherapy, metagenomic sequencing of faecal samples revealed that Phocaeicola vulgatus abundance was approximately 12 times higher in nonresponders than in responders. P. vulgatus rapidly hydrolysed taurine-conjugated bile acids, leading to ceramide accumulation and reversing the improvements in glucose intolerance conferred by metformin in high-fat diet-fed mice. Interestingly, C22:0 ceramide bound to mitochondrial fission factor to induce mitochondrial fragmentation and impair hepatic oxidative phosphorylation in P. vulgatus-colonized hyperglycaemic mice, which could be exacerbated by metformin. This work suggests that metformin may be unsuitable for P. vulgatus-rich T2DM patients and that clinicians should be aware of metformin toxicity to mitochondria. Suppressing P. vulgatus growth with cefaclor or improving mitochondrial function using adenosylcobalamin may represent simple, safe, effective therapeutic strategies for addressing MMF.

Designation of ideological and political teaching of Medical Immunology courses focuses on"cultivate talent for Party and the State",and adheres to goal of"build morality and cultivate people".From perspective of big ideology and politics,with basic foundation of"major guiding,disciplines supporting and curriculum shaping",principle of"six combinations"is applied to con-struct ideological and political cases of Medical Immunology courses,to create an infiltrating teaching pattern,which simultaneously cultivate talent for the Party and the State,and forms a synergistic effect of professional course learning and ideological and political learning.

Extraintestinal manifestations (EIM) of inflammatory bowel disease (IBD) may affect multiple organ systems, with approximately 50% of IBD patients presenting with at least one EIM during the course of their disease, with cutaneous involvement being particularly common. Cutaneous manifestations can present in various forms. This paper reports a case of ulcerative colitis (UC) complicated with bullous pemphigoid (BP), aiming to enhance clinicians' awareness of skin lesions associated with UC.

Objective:To explore the direction of the association between smartphone multitasking behavior and comorbid symptoms of anxiety and depression (CAD) among college students.Methods:College students from one college located in Shanxi, Chongqing, and Shenzhen were selected between October and December 2021 using a multistage random cluster sampling method, and a follow-up visit was conducted in May 2022. The Assessment of Smartphone Multitasking for Adolescents, the Patient Health Questionnaire-9 Items, and the Generalized Anxiety Disorder Questionnaire-7 Items were used to assess the smartphone multitasking behaviors and CAD of college students. Multivariate logistic regression models were used to analyze the associations between smartphone multitasking behavior and CAD. Autoregressive cross-lagged models (ARCLM) were used to analyze the bidirectional associations between smartphone multitasking behavior and CAD.Results:A total of 953 college students were included in this study, including 323 (33.9%) males and 630 (66.1%) females, with an age of (18.89±1.33) years. The detection rates of CAD at baseline and follow-up were 25.5% and 27.5%, respectively. The mean of the total smartphone multitasking index at baseline was 2.11±0.48. The mean of smartphone and non-media activity multitasking index was 2.00±0.55. The mean of smartphone and other media activity multitasking index was 1.92±0.67. The mean of smartphone functional use multitasking index was 2.18±0.54. The multivariate logistic regression models showed that smartphone and non-media activity multitasking index ( OR=1.85, 95% CI: 1.39-2.45), smartphone and other media activity multitasking index ( OR=1.42, 95% CI: 1.10-1.83), and total smartphone multitasking index ( OR=1.66, 95% CI: 1.21-2.28) were positively associated with the risk of CAD among college students at baseline. The smartphone and non-media activity multitasking index ( OR=1.74,95% CI: 1.30-2.32), smartphone and other media activity multitasking index ( OR=1.37, 95% CI: 1.04-1.79) and total smartphone multitasking index ( OR=1.48, 95% CI: 1.06-2.06) were positively associated with the risk of CAD at follow-up. There was no statistical association between smartphone functional use multitasking index at baseline and CAD. The ARCLM showed that smartphone and non-media activity multitasking index ( β=0.974, P=0.029), smartphone and other media multitasking index ( β=0.798, P=0.003), and the total smartphone multitasking index ( β=1.379, P=0.011) at baseline could positively predict the risk of CAD at follow-up. The CAD at baseline could positively predict smartphone and other media multitasking index ( β=0.004, P=0.016) and smartphone functional use multitasking index at follow-up ( β=0.004, P=0.016). Conclusion:There is a bidirectional association between smartphone and other media activity multitasking and CAD among college students.

Acute necrotic encephalopathy（ANE）is commonly associated with central nervous system disorders following viral infection.The cytokine storm caused by the abnormal systemic immune response of the host after infection may be an important pathogenesis of ANE.There is still a lack of consensus on standardized treatment options.The main therapeutic methods include immunotherapy，anti-cytokine therapy and symptomatic supportive therapy.Plasma exchange is one of the commonly used immunotherapy methods.At present，there is a lack of high evidence-based medical study evidence to confirm the effectiveness，but it is still a promising treatment and needs further exploration.