Objective:To explore the potential categories of emotional behavior and its influencing factors in obese junior high school students.Methods:A total of 1 841 obese junior high school students were selected by convenient sampling method and surveyed by basic information scale, co-residence (CRS), online time (OT), outdoor exercise intensity (OEI) and subjective socioeconomic status scale for adolescent(SSS-A) score, Chinese version of perceived stress scale(CPSS), short grit scale(Grit-S), adolescent mental health literacy assessment questionnaire(AMHLAQ) and strengths and difficulties questionnaire (SDQ).Statistical analysis were conducted by SPSS 26.0 software and Mplus 8.3 software.The latent class analysis was used to group the students according to the SDQ scores, and the disordered multivariate Logistic regression was used to explore the influencing factors of each category.Results:There were 4 latent categories of emotional behavior in obese junior high school students, which were anxiety-independence group (22.49%), depression-passive group (28.25%), contradiction-affinity group(24.72%) and stability-sociability group (24.55%).Students with low CPSS, Grit-S, AMHLAQ and SSS-A scores were more likely to enter the anxiety-independence group with stability-sociability group as a reference( B=0.893, OR=2.442, 95% CI=1.083-5.509; B=-1.645, OR=0.193, 95% CI=0.067-0.553; B=0.030, OR=1.031, 95% CI=1.007-1.055; B=-0.177, OR=0.883, 95% CI=0.812-0.953; B=-0.066, OR=0.934, 95% CI=0.899-1.081; B=-0.302, OR=0.739, 95% CI=0.695-0.786), living with one parent, and having low CPSS, Grit-S, and AMHLAQ scores; students with OT<1 h OEI≥4 d and low Grit-S total score were more likely to enter the depression-passive group( B=0.930, OR=2.715, 95% CI=1.206-5.945; B=-0.447, OR=0.572, 95% CI=0.363-0.953; B=-0.201, OR=0.818, 95% CI=0.793-0.844); students with high CPSS total score and low Grit-S and AMHLAQ total scores were easy to enter the contradiction-affinity group( B=-1.752, OR=0.174, 95% CI=0.054-0.562; B=0.087, OR=1.091, 95% CI=1.065-1.118; B=-0.273, OR=0.783, 95% CI=0.752-0.871; B=-0.036, OR=0.965, 95% CI=0.938-0.991); OEI≥4 d and OT <1 h were the protective factors of the stability-sociability group ( P<0.05). Conclusion:There is heterogeneity in the emotional and behavioral characteristics of obese junior high school students, which can be divided into four categories.Living with parents, controlling the length of time on the internet, maintaining a certain intensity of outdoor sports, strengthening stress management and perseverance quality training, and improving mental health literacy can help prevent emotional and behavioral problems.

Objective:To explore the potential categories of emotional behavior and its influencing factors in obese junior high school students.Methods:A total of 1 841 obese junior high school students were selected by convenient sampling method and surveyed by basic information scale, co-residence (CRS), online time (OT), outdoor exercise intensity (OEI) and subjective socioeconomic status scale for adolescent(SSS-A) score, Chinese version of perceived stress scale(CPSS), short grit scale(Grit-S), adolescent mental health literacy assessment questionnaire(AMHLAQ) and strengths and difficulties questionnaire (SDQ).Statistical analysis were conducted by SPSS 26.0 software and Mplus 8.3 software.The latent class analysis was used to group the students according to the SDQ scores, and the disordered multivariate Logistic regression was used to explore the influencing factors of each category.Results:There were 4 latent categories of emotional behavior in obese junior high school students, which were anxiety-independence group (22.49%), depression-passive group (28.25%), contradiction-affinity group(24.72%) and stability-sociability group (24.55%).Students with low CPSS, Grit-S, AMHLAQ and SSS-A scores were more likely to enter the anxiety-independence group with stability-sociability group as a reference( B=0.893, OR=2.442, 95% CI=1.083-5.509; B=-1.645, OR=0.193, 95% CI=0.067-0.553; B=0.030, OR=1.031, 95% CI=1.007-1.055; B=-0.177, OR=0.883, 95% CI=0.812-0.953; B=-0.066, OR=0.934, 95% CI=0.899-1.081; B=-0.302, OR=0.739, 95% CI=0.695-0.786), living with one parent, and having low CPSS, Grit-S, and AMHLAQ scores; students with OT<1 h OEI≥4 d and low Grit-S total score were more likely to enter the depression-passive group( B=0.930, OR=2.715, 95% CI=1.206-5.945; B=-0.447, OR=0.572, 95% CI=0.363-0.953; B=-0.201, OR=0.818, 95% CI=0.793-0.844); students with high CPSS total score and low Grit-S and AMHLAQ total scores were easy to enter the contradiction-affinity group( B=-1.752, OR=0.174, 95% CI=0.054-0.562; B=0.087, OR=1.091, 95% CI=1.065-1.118; B=-0.273, OR=0.783, 95% CI=0.752-0.871; B=-0.036, OR=0.965, 95% CI=0.938-0.991); OEI≥4 d and OT <1 h were the protective factors of the stability-sociability group ( P<0.05). Conclusion:There is heterogeneity in the emotional and behavioral characteristics of obese junior high school students, which can be divided into four categories.Living with parents, controlling the length of time on the internet, maintaining a certain intensity of outdoor sports, strengthening stress management and perseverance quality training, and improving mental health literacy can help prevent emotional and behavioral problems.

Objective:To summarize the clinical features of 8 cases with intramycardial hematoma(IMH) following congenital cardiac surgery in children.Methods:We retrospectly searched 8 patients with intramycardial hematoma after congenital cardiac surgery in Guangzhou Women and Children’s Medical Center from 2008 to 2024.Results:Mean age and mean weight at surgery were(13±15) months and(7.8±3.5)kg respectively. 6 of 8 cases were interventricular septal hematoma. In the other 2 patients, intramycardial hematoma was located in left ventrical free wall. All IMH were postoperatively detected by transthoracic echocardiaography. Two patients were managed with ECMO intraoperatively. Finally, all patients were discharged successfully with good clinical results. Mean time to IMH resolution in six patients was(33.5±4.6) days and mean left ventricular ejection fraction(LVEF) was 0.60±0.09. Another patient was followed up for 3 months and the IMH was not absorbed. One patient was lost to follow-up.Conclusion:IMH is a rare complication after congenital heart disease. The absorption of hematoma is a dynamic process and mean time to IMH resolution is about 1month. In IMH patients with hemodynamic instability, ECMO can be a good treatment to create opportunities for hematoma absorbtion.

Objective To explore the impact of pH value of the reaction system on the properties of bovine hemoglobin modified with aldehydeated polyethylene glycol(PEG-bHb).Methods PEG-bHb conjugates were synthesized under varying pH conditions(6.0,6.5,7.4 and 8.0)of the reaction system while consistent molar ratios,temperature,and reaction time were maintained.The structural and functional attributes of PEG-bHb were characterized.Results The proportion of methemoglobin decreased with an increase in pH.In a weakly acidic reaction environment,the PEG-bHb was found to be relatively highly modified.At pH 6.5,the average number of PEG chains attached to the bHb surface was 6.86±0.38.Selective PEG modification of the N-terminal α-NH2 groups was more pronounced under weakly acidic conditions.Specifically,at pH 6.5,the modification efficiency of the N-terminal α-NH2 groups of bHb by aldehyde-activated PEG reached 95.4％for the α-chains and 99.3％for the β-chains.The PEG modification influenced the heme region microenvi-ronment of bHb,with minimal structural impact observed at pH 6.5.After modification,the oxygen affinity of PEG-bHb was enhanced,the Hill coefficient was reduced,and there were significant increases in colloid osmotic pressure,viscosity,and particle size,all of which differed markedly from the unmodified bHb group(P＜0.001).Conclusion The synthesis of PEG-bHb under weakly acidic conditions can result in a high degree of selective modification of the N-terminal α-NH2 groups and an overall high degree of modification.

Objective:To compare the accuracy of dynamic navigation system,fully-guided and Pilot-drill guided implant surgery in anterior dental aesthetic area.Methods:45 patients underwent single tooth implantation in anterior dental aesthetic area were random-ly divided into 3 groups(n=15).Dynamic navigation system imlanting(A),3D printing fully-guided template with ASTRA EV assis-ted orthopedic implantation(B)and Pilot-drill guided implantation(C)were respectively used for the patients in group A,B and C.The deviation between the preoperative design and actual results were measured by CBCT and/or 3D reconstruction with navigation de-sign software or 3SHAPE software.SPSS 25.0 software package was used and(x)±s was used for descriptive analysis,results were pair-wise compared among the 3 groups using ANOVA.Results:Data were normally distributed and the variance of the data was homoge-neous.In group A,the distance deviation of implant top center was(0.571±0.196)mm,the horizontal deviation was(0.405±0.222)mm,the distance deviation of implant apical center was(0.449±0.267)mm,the vertical deviation was(0.312±0.223)mm,the de-viation of the connection angle between the two centers was 2.257°±0.989°.In group B,those were(0.520±0.242)mm,(0.219±0.201)mm,(0.643±0.284)mm,(0.464±0.292)mm and 1.272°±0.951° respectively.In group C those were(1.179±0.365)mm,(0.667±0.276)mm,(1.518±0.566)mm,(0.967±0.444)mm and 2.568°±0.632°.The deviation of all the measurments of group A and B was lower than those of group C(P＜0.05).The deviation of the connection angle between the 2 centers of group B was less than that of group A(P＜0.05),but no statistical significance(P＞0.05)was found in other 4 measured items.Conslusion:The accuracy of the dynamic navigation system and the fully-guided implantation is significantly higher than that of the Pilot-drill guided implantation,but is not statistically significant between dynamic navigation and the fully-guided system.

Objective:The present study aims to investigate whether there is a shared alteration of the resting-state functional connectivity and amplitude of low frequency fluctuation (ALFF) within the limbic network across all three clinical phases of bipolar disorder.Methods:From July 2019 to December 2021, 107 patients diagnosed with bipolar disorder (bipolar disorder group) were recruited from the Institute of Mental Health at Xiangya Second Hospital, Central South University. Additionally, 46 healthy controls matched for age, gender, and education level were enrolled as the control group. According to the total scores of the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAMD 17), individuals with bipolar disorder can be categorized into three groups: bipolar manic group, bipolar depressive group, and bipolar euthymic group. Resting state functional magnetic resonance imaging data were collected from all the participants, and seed-based functional connectivity and ALFF in the limbic network were conducted to compare differences among three mood states and controls using One-way ANOVA and post hoc analysis. Finally, correlation analyses using Pearson or Spearman coefficients were performed between statistically significant intergroup differences in functional connectivity/ALFF values and total scores as well as factor scores on clinical rating scales. Results:In comparison to the healthy controls, there was a significant decrease in functional connectivity between the anterior cingulate gyrus and hippocampus across all three clinical phases of bipolar disorder after Bonferroni correction ( t=-2.60--2.07, P<0.05). Furthermore, the ALFF in the anterior cingulate gyrus during three phases showed a significantl reduction following false discovery rate correction ( t=-4.41--3.51, P<0.05). Moreover, a decreased functional connectivity between the left anterior cingulate gyrus and left hippocampus during the depressive phase demonstrated a significant negative correlation with work interest subscores of the HAMD 17 ( r=-0.406, P=0.021). Conclusions:Dysconnectivity and reduced activity within the anterior cingulate of the limbic network may represent common alterations of mood regulation disorder throughout all three clinical phases of bipolar disorder.

Objective:The present study aims to investigate whether there is a shared alteration of the resting-state functional connectivity and amplitude of low frequency fluctuation (ALFF) within the limbic network across all three clinical phases of bipolar disorder.Methods:From July 2019 to December 2021, 107 patients diagnosed with bipolar disorder (bipolar disorder group) were recruited from the Institute of Mental Health at Xiangya Second Hospital, Central South University. Additionally, 46 healthy controls matched for age, gender, and education level were enrolled as the control group. According to the total scores of the Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAMD 17), individuals with bipolar disorder can be categorized into three groups: bipolar manic group, bipolar depressive group, and bipolar euthymic group. Resting state functional magnetic resonance imaging data were collected from all the participants, and seed-based functional connectivity and ALFF in the limbic network were conducted to compare differences among three mood states and controls using One-way ANOVA and post hoc analysis. Finally, correlation analyses using Pearson or Spearman coefficients were performed between statistically significant intergroup differences in functional connectivity/ALFF values and total scores as well as factor scores on clinical rating scales. Results:In comparison to the healthy controls, there was a significant decrease in functional connectivity between the anterior cingulate gyrus and hippocampus across all three clinical phases of bipolar disorder after Bonferroni correction ( t=-2.60--2.07, P<0.05). Furthermore, the ALFF in the anterior cingulate gyrus during three phases showed a significantl reduction following false discovery rate correction ( t=-4.41--3.51, P<0.05). Moreover, a decreased functional connectivity between the left anterior cingulate gyrus and left hippocampus during the depressive phase demonstrated a significant negative correlation with work interest subscores of the HAMD 17 ( r=-0.406, P=0.021). Conclusions:Dysconnectivity and reduced activity within the anterior cingulate of the limbic network may represent common alterations of mood regulation disorder throughout all three clinical phases of bipolar disorder.

Objective: To investigate the proportion of physical examinations among patients with severe mental disorders and its influencing factors in Shaoxing City, Zhejiang Province, so as to provide the evidence for improving the proportion of physical examinations among patients with severe mental disorders. Methods : The epidemiological and clinical features of patients with severe mental disorders included in community management in Shaoxing City in 2022 were collected from Zhejiang Provincial Severe Mental Disorder Management Information System, including demographics, disease diagnosis and treatment, physical examination, and rescue and assistance. Factors affecting the physical examination were identified among patients with severe mental disorders using a multivariable logistic regression model. Results: A total of 25 468 patients with severe mental disorders were enrolled in Shaoxing City in 2022, including 12 151 males and 13 317 females, with a male to female ratio of 0.91∶1, and the participants had a mean age of (54.34±14.71) years. Schizophrenia was the predominant type of severe mental disorders (15 419 cases, 60.54%), and 21 374 subjects participating in the physical examinations in 2022 (83.92%). Multivariable logistic regression analysis showed that female (OR=0.901, 95%CI: 0.832-0.975), urban areas (OR=0.506, 95%CI: 0.468-0.547), mental disorders due to epilepsy (OR=1.779, 95%CI: 1.104-2.866), hospitalized treatment (6 to 10 times, OR=0.523, 95%CI: 0.401-0.681; 11 times and more, OR=0.177, 95%CI: 0.108-0.288), special diseases in outpatient (OR=1.738, 95%CI: 1.597-1.891), receiving medical assistance (OR=2.851, 95%CI: 2.616-3.107), targets of the community care and assistance groups (OR=1.653, 95%CI: 1.471-1.857) and guardian (spouse, OR=1.777, 95%CI: 1.513-2.086; children, OR=1.277, 95%CI: 1.069-1.526; parents, OR=1.342, 95%CI: 1.143-1.576) were statistically associated with the proportion of physical examinations. Conclusions The proportion of health examinations was 83.92% among patients with severe mental disorders in Shaoxing City in 2022. Gender, residence, guardian, disease diagnosis, times of hospitalized treatment, medical assistance, special diseases in outpatients and target of community care and assistance groups were factors affecting health examinations among patients with severe mental disorders.

Znic (Zn) alloys with good cytocompatibility and suitable degradation rate have been a kind of biodegradable metal with great potential for clinical applications. This paper summarizes the biological role of degradable Zn alloy as bone implant materials, discusses the mechanical properties of different Zn alloys and their advantages and disadvantages as bone implant materials, and analyzes the influence of different processing strategies (such as alloying and additive manufacturing) on the mechanical properties of Zn alloys. This paper provides systematic design approaches for biodegradable Zn alloys as bone implant materials in terms of the material selection, product processing, structural topology optimization, and assesses their application prospects with a view to better serve the clinic.
Orthopedics ; Zinc ; Alloys ; Dental Materials ; Prostheses and Implants

Objective:Analyze the perioperative data of children undergoing cardiopulmonary bypass(CPB) for congenital heart disease under the management of ultra-fast track anesthesia(UFTA), the factors of CPB are discussed.Methods:1 034 children who underwent CPB from May 2018 to August 2019 were analyzed retrospectively. According to the success of anesthesia, they were divided into two groups: UFTA group and UFTA failure group. Propensity score matching was used to screen the children with preoperative baseline data matching. Finally 346 cases in each group. The possible CPB factors of the two groups were analyzed by single factor analysis, and the statistically significant factors were analyzed by logistic regression analysis. Results:Univariate analysis showed that the CPB and aortic occlusion time, the lowest temperature and lowest hematocrit in CPB, the dosage of crystalloid and suspended erythrocytes, the second or more times of CPB, and the blood lactate after CPB were the factors influencing the ultra-fast track anesthesia. Logistic regression analysis showed that the time of CPB and aortic occlusion, the value of blood lactate, the dosage of suspended erythrocytes, and the second or more times of CPB were the independent influencing factors of ultra-fast track anesthesia. In the UFTA failure group, the postoperative hospitalization time, the length of stay in the ICU and the hospitalization cost were all higher than those in the ultra-fast track group. Conclusion:CPB time, aortic occlusion time, blood lactate after CPB, the dosage of suspended erythrocytes, secondary or multiple CPB were independent risk factors for UFTA.UFTA is beneficial to shorten the postoperative hospital stay, the ICU stay and the cost of hospitalization.