Background: To assess the effectiveness of hyperbaric oxygen therapy (HBOT) as an adjunct to standard treatment in early-stage oral submucous fibrosis (OSMF), focusing on mouth opening, burning sensation, pain, and systemic inflammation. Methods: A randomized comparative study was conducted on early-stage OSMF patients divided into two groups. Group 1 received HBOT along with intralesional triamcinolone, hyaluronidase, and oral antioxidants. Group 2 received only the standard intralesional therapy with antioxidants. Clinical parameters—interincisal distance, burning sensation, and pain—were recorded at baseline, first, and second followup. Serum C-reactive protein (CRP) levels were measured pre- and post-treatment. Statistical analysis included unpaired t-tests and chisquare tests. Results: Both groups improved clinically, but Group 1 showed significantly greater reductions in burning sensation (p= 0.020), pain, and CRP levels (p= 0.033). Although intergroup differences in mouth opening were not statistically significant, Group 1 showed greater improvement over time. Fibrotic band distribution remained unchanged in both groups. No complications were reported with HBOT. Conclusion HBOT provides enhanced symptomatic relief and anti-inflammatory effects in early-stage OSMF when used alongside conventional therapy. While it may not reverse fibrosis, its safety and noninvasive nature support its role in multimodal OSMF management.

Skull base defects often manifest as meningocele/meningoencephalocele or cerebrospinal fluid (CSF) leaks. Ventral and lateral skull base defects are effectively treated endoscopically and microscopically using various approaches. This case series study analyzes the utility and efficacy of post-aural soft tissue and temporalis fascia grafts in repairing small (<1 cm) skull base defects. Five out of six patients (83.33%) achieved successful defect closure. Patients were followed for donor site morbidity, postoperative CSF leak, and/or recurrent meningocele. One patient experienced reconstruction failure and developed a CSF leak eight months after surgery. The results suggest that TF grafts combined with post-aural soft tissue may be effectively used to repair small skull base defects without significant donor site morbidity.

Objectives: The objective of this review was to analyze quantitative data on autism spectrum disorder (ASD) and to increase the accuracy of estimates of the prevalence of ASD. Methods: This review, which was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, included studies conducted from January 2008 to June 2024 on children aged 3 to 18 years that used standardized measurement tools and reported cut-off scores for ASD. The prevalence of ASD was the primary outcome analyzed in this review. The PubMed, Clinical Key, Scopus, Embase, CINAHL, and Web of Science databases were reviewed for relevant studies. The review protocol was registered with PROSPERO and followed the Cochrane collaboration guidelines. Results: A total of 66 studies reported on the prevalence of ASD, screening 21,313,061 children worldwide. Among these, 25 studies were conducted in Europe, 22 in Asia, and 13 in America.Additionally, 3 studies each were reported from Africa and Australia. According to a metaanalysis, 0.77% of children globally are diagnosed with ASD, with boys comprising 1.14% of this group. Notably, Australia showed the highest prevalence rate, with an effect size of 2.18, highlighting it as a critical area for public health focus. Conclusion ASD represents a significant global health burden. Early detection, increasedawareness among parents, and prompt intervention are crucial for mitigating developmental problems in children later in life. It is essential for health policymakers to acknowledge theprevalence and growing trends of ASD in order to implement effective interventions.

Azoospermia is characterized by the absence of sperm in the ejaculate and is categorized into obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). For men with NOA, testicular sperm extraction (TESE) is the only method to obtain sperm for assisted reproductive technology (ART). Given the rarity of these sperm and the unpredictable success of subsequent retrieval attempts, cryopreservation of microdissection-TESE-obtained sperm is essential. Effective cryopreservation prevents the need for repeated surgical procedures and supports future ART attempts. After first delving into the physiological and molecular aspects of sperm cryopreservation, this review aims to examine the current methods and devices for preserving small numbers of sperm. It presents conventional freezing and vitrification techniques, evaluating their respective strengths and limitations in effectively preserving rare sperm, and compares the efficacy of using fresh versus cryopreserved testicular sperm.
Humans ; Cryopreservation/methods* ; Male ; Sperm Retrieval ; Azoospermia/therapy* ; Semen Preservation/methods* ; Spermatozoa ; Vitrification

Animals, Wild ; Borneo ; Malaysia ; Biosurveillance

Objectives: The objective of this review was to analyze quantitative data on autism spectrum disorder (ASD) and to increase the accuracy of estimates of the prevalence of ASD. Methods: This review, which was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, included studies conducted from January 2008 to June 2024 on children aged 3 to 18 years that used standardized measurement tools and reported cut-off scores for ASD. The prevalence of ASD was the primary outcome analyzed in this review. The PubMed, Clinical Key, Scopus, Embase, CINAHL, and Web of Science databases were reviewed for relevant studies. The review protocol was registered with PROSPERO and followed the Cochrane collaboration guidelines. Results: A total of 66 studies reported on the prevalence of ASD, screening 21,313,061 children worldwide. Among these, 25 studies were conducted in Europe, 22 in Asia, and 13 in America.Additionally, 3 studies each were reported from Africa and Australia. According to a metaanalysis, 0.77% of children globally are diagnosed with ASD, with boys comprising 1.14% of this group. Notably, Australia showed the highest prevalence rate, with an effect size of 2.18, highlighting it as a critical area for public health focus. Conclusion ASD represents a significant global health burden. Early detection, increasedawareness among parents, and prompt intervention are crucial for mitigating developmental problems in children later in life. It is essential for health policymakers to acknowledge theprevalence and growing trends of ASD in order to implement effective interventions.

Skull base defects often manifest as meningocele/meningoencephalocele or cerebrospinal fluid (CSF) leaks. Ventral and lateral skull base defects are effectively treated endoscopically and microscopically using various approaches. This case series study analyzes the utility and efficacy of post-aural soft tissue and temporalis fascia grafts in repairing small (<1 cm) skull base defects. Five out of six patients (83.33%) achieved successful defect closure. Patients were followed for donor site morbidity, postoperative CSF leak, and/or recurrent meningocele. One patient experienced reconstruction failure and developed a CSF leak eight months after surgery. The results suggest that TF grafts combined with post-aural soft tissue may be effectively used to repair small skull base defects without significant donor site morbidity.

Skull base defects often manifest as meningocele/meningoencephalocele or cerebrospinal fluid (CSF) leaks. Ventral and lateral skull base defects are effectively treated endoscopically and microscopically using various approaches. This case series study analyzes the utility and efficacy of post-aural soft tissue and temporalis fascia grafts in repairing small (<1 cm) skull base defects. Five out of six patients (83.33%) achieved successful defect closure. Patients were followed for donor site morbidity, postoperative CSF leak, and/or recurrent meningocele. One patient experienced reconstruction failure and developed a CSF leak eight months after surgery. The results suggest that TF grafts combined with post-aural soft tissue may be effectively used to repair small skull base defects without significant donor site morbidity.

Objectives: The objective of this review was to analyze quantitative data on autism spectrum disorder (ASD) and to increase the accuracy of estimates of the prevalence of ASD. Methods: This review, which was reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, included studies conducted from January 2008 to June 2024 on children aged 3 to 18 years that used standardized measurement tools and reported cut-off scores for ASD. The prevalence of ASD was the primary outcome analyzed in this review. The PubMed, Clinical Key, Scopus, Embase, CINAHL, and Web of Science databases were reviewed for relevant studies. The review protocol was registered with PROSPERO and followed the Cochrane collaboration guidelines. Results: A total of 66 studies reported on the prevalence of ASD, screening 21,313,061 children worldwide. Among these, 25 studies were conducted in Europe, 22 in Asia, and 13 in America.Additionally, 3 studies each were reported from Africa and Australia. According to a metaanalysis, 0.77% of children globally are diagnosed with ASD, with boys comprising 1.14% of this group. Notably, Australia showed the highest prevalence rate, with an effect size of 2.18, highlighting it as a critical area for public health focus. Conclusion ASD represents a significant global health burden. Early detection, increasedawareness among parents, and prompt intervention are crucial for mitigating developmental problems in children later in life. It is essential for health policymakers to acknowledge theprevalence and growing trends of ASD in order to implement effective interventions.