Background: The World Health Organization (WHO) recommends using both the ICD and ICF frameworks in combination when assessing work disability. The ICF evaluates patients in terms of body functions, disability, and health-related functioning. Integrating ICD and ICF classifications is essential for accurate disability assessment, effective rehabilitation planning, and compensation processes. Aim: To investigate environmental factors influencing rehabilitation services among patients with work-related diseases who have experienced loss of work capacity, using the International Classification of Functioning, Disability and Health (ICF) framework. Materials and Methods: This analytical cross-sectional study was conducted at the Department of Occupational Medicine of the Occupational Health Center. Data were collected from 150 patients with occupational diseases resulting in work disability. The ICF assessment tool developed by WHO was utilized. A total of 150 indicators across four main domains were assessed: 27 items on general information and health-related issues; 31 items on body functions (Group 1a); 16 items on body structures (Group 1b); 48 items on activities and participation (Group 2); and 32 items on environmental factors (Group 3). Statistical analysis was performed using SPSS version 26.0 Descriptive statistics, including frequencies, percentages, means, and standard deviations, were calculated. Results: A total of 150 patients with work disability due to occupational diseases were included in the study. The mean age was 60.5±10.9 years, with males comprising 80% (n=120) and females 20% (n=30). The reliability of the ICF questionnaire was acceptable across all domains (Cronbach’s alpha > 0.7). Respiratory occupational diseases accounted for the largest proportion 58.7% ( n=88), followed by neurological conditions 19.3% (n=29) and surgical conditions 8.7% (n=13). Environmental factors affecting rehabilitation, support from health professionals (e360) showed moderate facilitation (2.0±1.0). In contrast, climate (e225) (-2.7±0.6), education services (e585) (-3.4±0.8), and employment services (e590) (-3.5±0.7) were identified as substantial barriers. Environmental factors were significantly associated with age and duration since diagnosis of occupational disease (p<0.05). Conclusions 1. The integrated application of the International Classification of Diseases (ICD) and the International Classification of Functioning, Disability and Health (ICF) allow for a more comprehensive evaluation of work-related disability. This approach moves beyond a purely diagnosis-based assessment to incorporate functional status and environmental determinants. 2. The findings highlight its significant value in optimizing rehabilitation service planning, identifying key barriers, and ultimately improving both the accessibility and effectiveness of rehabilitation services.