With the acceleration of the aging process and change in social lifestyle， the prevalence rate of late-life depression （LLD） in the elderly is increasing year by year. As the most common mental disorder in the elderly， LLD seriously affects the quality of life of patients， and thus brings a heavy burden to the family and society. It may even become life-threatening for the elderly patients. The pathogenesis of LLD is still unclear， which may be caused by a combination effects of biological， social and psychological factor. Given the declined body functions and more comorbid physical diseases in the elderly population， the diagnosis and treatment of LLD patients would be different from that of younger adult patients with depression. This paper reviews the epidemiological characteristics， clinical evaluation， diagnosis， comorbidity， treatment and intervention of LLD， and focuses on the selection of therapeutic drugs and adverse reactions， in order to provide references for better diagnosis and treatment of LLD and improve the prognosis of patients.

Addictive behaviour refers to those repetitive behaviours which can lead to typical rewarding effects in related brain regions with great potential to "addictiveness". People engaged in such behaviours may develop mental disorders associated with functional impairment or distress. In ICD-11, video gaming and gambling are two major addictive behaviours. Globally, there has been a trend of the convergence between gaming and gambling, significantly aided by the rapid development of information technology. The trend introduces a new challenge for public health, especially in the sphere of behavioural addiction. Against this background, this article elucidates the definition of gaming and gambling, the convergence, and its public health implications and corresponding countermeasures.

Addictive behaviour refers to those repetitive behaviours which can lead to typical rewarding effects in related brain regions with great potential to "addictiveness". People engaged in such behaviours may develop mental disorders associated with functional impairment or distress. In ICD-11, video gaming and gambling are two major addictive behaviours. Globally, there has been a trend of the convergence between gaming and gambling, significantly aided by the rapid development of information technology. The trend introduces a new challenge for public health, especially in the sphere of behavioural addiction. Against this background, this article elucidates the definition of gaming and gambling, the convergence, and its public health implications and corresponding countermeasures.

Klein-Levin syndrome is a chronic recurrent sleep disorder characterized by periodic excessive sleep, which can be accompanied by cognitive dysfunction, eating disorders, behavioral disorders, sensory disorders and emotional disorders, etc. During interval, individual′s daily functions are completely normal. Most of the KLS cases are sporadic. At present, only 17 familial cases of KLS have been reported abroad, while domestic reports in China are rare. We analyzed the detailed medical history, laboratory examinations, differential diagnosis, and the disease prevalence amongst family members of a patient with familial KLS, in order to provide reference for the follow-up study of familial cases of KLS.

Bipolar disorder is a chronic and recurrent mental disorder with alteration of manic/hypomanic episode and depressive episode. It commonly comorbid with anxiety disorder, substance abuse, impulse control disorder, borderline personality disorder, and so forth. We analyzed a case of bipolar disorder comorbid with nitrous oxide use disorder, which would be beneficial for clinicians to identify and deal with such patients.

Klein-Levin syndrome is a chronic recurrent sleep disorder characterized by periodic excessive sleep, which can be accompanied by cognitive dysfunction, eating disorders, behavioral disorders, sensory disorders and emotional disorders, etc. During interval, individual′s daily functions are completely normal. Most of the KLS cases are sporadic. At present, only 17 familial cases of KLS have been reported abroad, while domestic reports in China are rare. We analyzed the detailed medical history, laboratory examinations, differential diagnosis, and the disease prevalence amongst family members of a patient with familial KLS, in order to provide reference for the follow-up study of familial cases of KLS.

Bipolar disorder is a chronic and recurrent mental disorder with alteration of manic/hypomanic episode and depressive episode. It commonly comorbid with anxiety disorder, substance abuse, impulse control disorder, borderline personality disorder, and so forth. We analyzed a case of bipolar disorder comorbid with nitrous oxide use disorder, which would be beneficial for clinicians to identify and deal with such patients.

Objective To investigate the differences of socio-demographics and smartphone use features among Chinese college students between problematic smartphone user (PSU) and non-PSU, and to clarify the link between PSU and psychopathological symptoms (anxiety and depression). Methods A total of 1205 undergraduates from 35 classes of 8 universities or colleges, stratified with different school levels, were selected using the cluster random sampling strategy. The Problematic Cellular Phone Use Questionnaire (PCPUQ) was used to identify problematic use of smartphone use, and Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS) were used to measure anxiety and depression symptoms. Results The prevalence of PSU among undergraduates was estimated to be 20.6% (207/1006). There were significant differences between PSU and non-PSU on their major of either science category or humanities category (χ2=11.424, P<0.01), grade (χ2=5.868, P<0.05), monthly living expense supported by their family (χ2=12.713, P<0.01), daily time spent on their smartphones (χ2=20.052, P<0.01), frequency of changing the mobile phones (χ2=14.511, P<0.01) and monthly smartphone bill (χ2=13.107, P<0.01). Furthermore, the self rated anxiety (34.8% (72/207) vs. 14.6% (117/799),χ2=43.704, P<0.01) and depression (36.2%(75/207) vs. 15.4%(123/799),χ2=45.159,P<0.01) were both found more elevated in PSU than non-PSU. Conclusion Some common sociodemographic variables and smartphone usage patterns were identified in undergraduates displaying PSU. Moreover, PSU is associated with more elevated anxiety and depression symptoms.

Objective To investigate the differences of socio-demographics and smartphone use features among Chinese college students between problematic smartphone user (PSU) and non-PSU, and to clarify the link between PSU and psychopathological symptoms (anxiety and depression). Methods A total of 1205 undergraduates from 35 classes of 8 universities or colleges, stratified with different school levels, were selected using the cluster random sampling strategy. The Problematic Cellular Phone Use Questionnaire (PCPUQ) was used to identify problematic use of smartphone use, and Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS) were used to measure anxiety and depression symptoms. Results The prevalence of PSU among undergraduates was estimated to be 20.6% (207/1006). There were significant differences between PSU and non-PSU on their major of either science category or humanities category (χ2=11.424, P<0.01), grade (χ2=5.868, P<0.05), monthly living expense supported by their family (χ2=12.713, P<0.01), daily time spent on their smartphones (χ2=20.052, P<0.01), frequency of changing the mobile phones (χ2=14.511, P<0.01) and monthly smartphone bill (χ2=13.107, P<0.01). Furthermore, the self rated anxiety (34.8% (72/207) vs. 14.6% (117/799),χ2=43.704, P<0.01) and depression (36.2%(75/207) vs. 15.4%(123/799),χ2=45.159,P<0.01) were both found more elevated in PSU than non-PSU. Conclusion Some common sociodemographic variables and smartphone usage patterns were identified in undergraduates displaying PSU. Moreover, PSU is associated with more elevated anxiety and depression symptoms.

OBJECTIVE:To provide reference for the safe and rational drug use for children. METHODS:Information manage-ment system was used to investigate the use of essential medicines system variety in stock in 2015 and analyze the medication infor-mation for children in the drug instructionsin our hospital in 2015. RESULTS:Only 201 kinds of medicines belonged to children’s medicines in all the 685 kinds of medicines in our hospital. And 89 kinds (44.28%) of medicines belonged to essential medicine system among the 201 kinds of children’s medicines,in which,78 (87.60%) showed complete medication information for chil-dren;112 kinds(55.72%)of medicines belonged to non-essential medicine system,in which,38(33.93%)showed complete medi-cation information for children. The proportions of showing complete medication information for children in the essential medicines and in its chemicals,biological products,injections and oral preparations were higher than non-essential medicines,the differences were statistically significant(P<0.05). Only 41 kinds of medicines belonged to child-specific medicines among the 201 children’s medicines;62 showed complete medication information for children in the 73 kinds of essential medicines among the non-child-spe-cific medicines;only 13 showed complete medication information for children in the 87 kinds of non-essential medicines,the pro-portion of showing complete medication information for children in essential medicines among the non-child-specific medicines was higher than non-essential medicines,the difference was statistically significant(P<0.05). CONCLUSIONS:The use proportion of essential medicine system variety for children’s medicines is high in our hospital;but there are lacking of child-specific medicines and the medication information for children is insufficient. However,compared with non-essential medicines for children,the essen-tial medicines show better medication information for children in aspects of types,dosage form distribution and non-child-specific medicines,and it is suitable for children.