1.Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway.
Qian LI ; Yang ANG ; Qing-Qing ZHOU ; Min SHI ; Wei CHEN ; Yujie WANG ; Pan YU ; Bing WAN ; Wanyou YU ; Liping JIANG ; Yadan SHI ; Zhao LIN ; Shaozheng SONG ; Manlin DUAN ; Yun LONG ; Qi WANG ; Wentao LIU ; Hongguang BAO
Journal of Pharmaceutical Analysis 2025;15(3):101039-101039
Acute respiratory distress syndrome (ARDS) is a common respiratory emergency, but current clinical treatment remains at the level of symptomatic support and there is a lack of effective targeted treatment measures. Our previous study confirmed that inhalation of hydrogen gas can reduce the acute lung injury of ARDS, but the application of hydrogen has flammable and explosive safety concerns. Drinking hydrogen-rich liquid or inhaling hydrogen gas has been shown to play an important role in scavenging reactive oxygen species and maintaining mitochondrial quality control balance, thus improving ARDS in patients and animal models. Coral calcium hydrogenation (CCH) is a new solid molecular hydrogen carrier prepared from coral calcium (CC). Whether and how CCH affects acute lung injury in ARDS remains unstudied. In this study, we observed the therapeutic effect of CCH on lipopolysaccharide (LPS) induced acute lung injury in ARDS mice. The survival rate of mice treated with CCH and hydrogen inhalation was found to be comparable, demonstrating a significant improvement compared to the untreated ARDS model group. CCH treatment significantly reduced pulmonary hemorrhage and edema, and improved pulmonary function and local microcirculation in ARDS mice. CCH promoted mitochondrial peripheral division in the early course of ARDS by activating mitochondrial thioredoxin 2 (Trx2), improved lung mitochondrial dysfunction induced by LPS, and reduced oxidative stress damage. The results indicate that CCH is a highly efficient hydrogen-rich agent that can attenuate acute lung injury of ARDS by improving the mitochondrial function through Trx2 activation.
2.Clinical assessment of spectrum CT with material decomposition technique in overcoming renal cyst pseudoenhancement
Hong LIU ; Taihu WAN ; Yongliang WANG ; Zhuo ZHAO ; Lin LIU ; Yue QIAO ; Mengchao ZHANG
Chinese Journal of Medical Imaging Technology 2017;33(6):897-901
Objective To evaluate the value of material decomposition imaging of spectrum CT in overcoming renal cyst pseudoenhaneement.Methods Totally 80 patients with renal cysts (total 75 cysts) who underwent CT imaging with GSI mode were collected.The renal cysts were divided into 3 groups according to diameters,group A (diameters 0.5-<1.5 cm,n=25),B (1.5-<2.5 cm,n=25) and C (2.5-<3.5 cm,n=25) respectively.The iodine-water density imaging was reconstructed by using the GSI Viewer analysis software.The CT value and iodine-water concentration of the cysts were recorded.The difference of CT value,iodine-water concentration in unenhanced and enhanced dual phases in each group was compared.Results The difference of CT value between plain scan and parenchyma phase among the 3 groups had statistically significant difference (F=204.128,P<0.001),and the differences comparing any two were statistically significant (all P<0.05).The postcontrast attenuation increased more than 10 HU in group A and B,indicating renal cyst pseudoenhancement,and less than 10 HU in group C,which had no pseudoenhancement.There were statistical difference in iodine concentration of the cysts of the 3 groups in unenhance,cortical and parenchyma phases (all P<0.001),but the difference value in unenhance,cortical and parenchyma phases were less than 10 (100 μg/cm3),and the difference value of the 3 group was group A>group B>group C (all P<0.05).The water concentration of the cysts in group A descend in renal cortical and parenchyma phase with statistical difference (P<0.001),but the difference value was less than 10 mg/cms.Conclusion The measurements of iodine-water concentration appear to drift as well,the smaller the greater,The degree of the iodine concentration shifting is more obvious than water concentration.
3.Detection and monitoring technologies for life signals
Jiewen ZHENG ; Taihu WU ; Zhengbo ZHANG ; Zhen WAN
Chinese Medical Equipment Journal 2003;0(12):-
The detection and monitoring of life signals such as heartbeat, respir ation, bloodpressure and temperature are often used to determine the patient's death. On the basis of the theory of military medical service, this paper discus ses life signals detection and monitoring technologies in the field of military medicine. With the progress of sciences, technologies and informatization of Chi nese PLA, life signals detection and monitoring technologies, based on informati on technology, microelectronic technology, communication technology and etc, wil l be more and more important in the development of digital medical equipment.
4.Development of WFS-1 automatic cardiopulmonary resuscitator for closed chest cardiac compression
Taihu WU ; Zhen WAN ; Jinhui LUO
Chinese Medical Equipment Journal 2003;0(11):-
A pneumatic and electrically controlled cardiopulmonary resuscitator is developed for automatic closed chest cardiac compression.Oriented to closed chest compression,artificial ventilation,synchronous defibrillation and early advanced life support,this resuscitator is as excellent as foreign like products and is postured for first aid of pre-hospital and hospital patients with cardiac and respiratory arrest.
5.Innovative Practice of Biomedical Engineering in Clinic
Zhen WAN ; Zhengqiang LIU ; Taihu WU
Chinese Medical Equipment Journal 1993;0(05):-
The concept of Biomedical Engineering is introduced,as well as its advantages and clinical application.The characteristic of Biomedical Engineering which combing biomedicine with engineering is discussed by examples along with its innovative practice in clinic.Advices on future developing of Biomedical Engineering are brought forward.
6.Development of WMZ-03 anaesthesia workstation with chest intergrated with apparatus
Taihu WU ; Zhenxing SONG ; Zhen WAN ; Xiaofeng ZHANG
Chinese Medical Equipment Journal 1989;0(03):-
This paper introduces a type of anaesthesia workstation which is composed of two vertical medical chests, i.e. the upper and lower parts. Taken out of the chest, the two parts are butted against and locked to make the workstation ready for operation. After operation is finished, the two parts are uncoupled and put into the chests, and then the workstation can be stored and transported with the chests closed.
7.Design of pneumatic gas-control cardiopulmonary resuscitator for field first aid
Chinese Medical Equipment Journal 1989;0(04):-
In view of the special disadvantageous conditions in battlefield, a portable pneumatic gas -control cardiopulmonary resuscitator is developed for the critical wounded care in battlefield, which satisfies the requirements of medical physiological parameters.
8.Development of High Frequency Ventilators
Jinyang GUO ; Taihu WU ; Zhen WAN
Chinese Medical Equipment Journal 1989;0(04):-
High frequency ventilators(HFV) are introduced in such aspects as its contribution to the development of the ventilation, phylogeny, working principle in the physiological field, the advantages over normal-frequency ventilation, three common HFV modes and their application to medical therapy. The present situation of HFV is analyzed as well as it's developing trends and prospects.

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