Objective:To explore the application effect of a multidisciplinary full-process chain nursing program based on the online-to-offline (OTO) model for patients with Parkinson′s disease and providing theoretical basis for medical staff to guide patients' rehabilitation.Methods:A randomized controlled trial was conducted, and 80 patients with Parkinson′s disease who visited the Neurology Department of Qilu Hospital, Shandong University (Qingdao) from January to December 2023 were selected using convenience sampling. Patients were divided into an intervention group and a control group using random number table method, with 40 patients in each group. The control group received routine nursing interventions, while the intervention group received a multidisciplinary full-process chain nursing program based on the OTO model in addition to routine care. The quality of life, rehabilitation training outcomes, psychological status, and nursing satisfaction of the two groups were compared.Results:In the intervention group, there were 23 males and 17 females, with an age of (65.46 ± 3.04) years; in the control group, there were 24 males and 16 females, with an age of (65.02 ± 3.42) years. After intervention, the scores for quality of life, rehabilitation training outcomes, Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale in the intervention group were (163.57 ± 18.56), (44.18 ± 4.57), (6.27 ± 1.05) and (6.18 ± 1.05) respectively, while those in the control group were (139.42 ± 14.26), (37.54 ± 4.80), (11.53 ± 2.24) and (10.48 ± 2.22) respectively. There were statistically significant differences between the two groups ( t values were from 6.34 to 13.45, all P<0.05). Patient satisfaction was 97.50% (39/40) in the intervention group and 77.50% (31/40) in the control group, with a statistically significant difference ( χ2=7.31, P<0.05). Conclusions:Implementing a multidisciplinary full-process chain nursing program based on the OTO model for patients with Parkinson′s disease yields significant rehabilitation effects, improves negative emotions and quality of life, and is worthy of promotion in clinical practice.

Objective:To identify the health management needs of caregivers' for adolescent patients with scoliosis based on the journey map, and provide a reference for improving the medical experience and optimizing the whole-journey care level.Methods:On the basis of literature review, combined with semi-structured interview method and group discussion method, we conducted semi-structured interview with the main caregivers of 13 adolescent scoliosis patients in Union Hospital, Tongji Medical College, Huazhong University of Science and Technology in June to October 2024, analyzed the data and drew a journey map.Results:A total of 13 respondents who met the inclusion and exclusion criteria were recruited, including 5 men and 8 women, with an age range of 32 to 45 years. Caregivers' health management needs were summarized from three dimensions: tasks, emotions, and pain points, following a timeline.Through the visualization of the journey map, the caregiver's cognitive gaps during the covert phase, information anxiety and decision-making dilemmas, need for early diagnosis and treatment, and challenges in symptom management ect. in the entire journey of health management were presented, and fifteen themes were summarized.Conclusions:The needs of caregivers for the journey of health management of postoperative adolescent idiopathic scoliosis patients are diversified, and should be demand-oriented to provide precise care support, improve medical experience, and provide ideas and methods for research on postoperative patient health management service optimization.

Objective To understand the current situation of thirst in patients with cirrhosis and analyze its influencing factors,in order to improve medical staff's attention to thirst symptoms in patients with cirrhosis and provide theoretical basis for clinical intervention.Methods A total of 220 patients with cirrhosis who were hospitalized in the infection department of a tertiary A general hospital in Wuhan from March to June 2024 were selected by convenience sampling method.General data questionnaire,Numerical Score Scale and Thirst Distress Scale were used to investigate the factors affecting thirst sensation in patients with cirrhosis.Results A total of 202 valid questionnaires were collected,and the effective questionnaire recovery rate was 91.82％.The results showed that the incidence of thirst in patients with cirrhosis was 59.41％;the score of thirst was 3.00(3.00,6.00)points,and the mean score of thirst was 3.09.Among them,43.07％of the patients with cirrhosis were in the moderate to severe level of thirst.The score of Thirst Distress Scale is 6.00(6.00,17.00)points,and the average score of thirst distress was 11.62 points,which was in the medium level.47.03％of patients with cirrhosis indicated thirst distress,and 23.76％of patients with cirrhosis which was in the moderate and severe level of distress.The results of multiple linear regression analysis showed that the degree of ascites,the use of diuretics,the stage of disease,and the degree of thirst distress were the factors influencing the degree of thirst in patients with cirrhosis(P＜0.05).Gender,marital status,degree of ascites,use of diuretic drugs,disease stage and degree of thirst were the factors influencing degree of thirst distress in patients with cirrhosis(P＜0.05).Conclusion The incidence and severity of thirst in patients with cirrhosis are relatively high,and are affected by many factors.Medical staff should pay more attention to the management of thirst symptoms in patients with cirrhosis,and formulate targeted nursing measures or nursing programs according to the related influencing factors of thirst,so as to improve the comfort level of patients and improve the disease experience of patients.

Objective:To analyze the correlation between near work, screen time, outdoor time and myopia in children based on objective monitoring technology and to explore the influencing factors related to myopia in children.Methods:A cross-sectional study was conducted.From October 2022 to March 2023, the purposive sampling method was used to select 596 children in Grade 2 and Grade 3 from two primary schools in Shandong Province as study subjects.Eye-Monitor technology of eye-use behavior based on artificial intelligence was used to quantify parameters of near work, screen time and outdoor time.The eye-use behavior parameters were compared within each subject and between non-myopic and myopic children on weekdays and weekends.A multivariate binary logistic regression model was constructed to analyze the influencing factors related to myopia.The study protocol was approved by the Medical Ethics Committee of the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine (No.HEC-HY-2022023KY).Written informed consent was obtained from the legal guardian of each subject.Results:For each subject, the proportion of near work time on weekdays was greater than on weekends, the proportion of time spent looking at cell phones, computer screens, and outdoor activities was smaller, the duration of single continuous near eye use was longer, the tilt angle of the head in sitting position was greater, and the light intensity was stronger, showing statistically significant differences ( t=19.427, -9.964, -5.916, -10.470, 2.211, 2.898, 15.061; all P<0.05).During weekdays, compared with the non-myopia group, the myopia group had longer total near work duration, longer single continuous near eye use duration, shorter outdoor activity duration, closer eye use distance, larger proportion of near work time, and smaller proportion of outdoor activity time, showing statistically significant differences (all P<0.05).During weekends, compared with the non-myopia group, the myopia group had longer time spent looking at cell phones and computer screens, shorter outdoor activity time, greater proportion of time spent looking at cell phones and computer screens, and smaller proportion of outdoor activity time, with statistically significant differences (all P<0.05).During weekdays, after adjusting for confounding factors, longer single continuous near eye use duration ( OR=1.138, 95% CI: 1.086-1.192, P<0.001) was the risk factor for myopia, and longer working distance ( OR=0.906, 95% CI: 0.847-0.970, P=0.004) and longer outdoor activity time ( OR=0.127, 95% CI: 0.023-0.703, P=0.018) were protective factors for myopia.During weekends, after adjusting for confounding factors, longer time spent on looking at cell phone screens ( OR=2.437, 95% CI: 1.460-4.068, P<0.001) and longer time spent on looking at computer screens ( OR=2.260, 95% CI: 1.283-3.979, P=0.005) were risk factors for myopia, and longer outdoor activity time ( OR=0.624, 95% CI: 0.416-0.934, P=0.022) was the protective factor for myopia. Conclusions:The eyes with continuous near work, prolonged use of smartphone and computer screens, closer eye use distance, and less time spent outdoors have been confirmed to be significantly correlated with myopia based on objective monitoring data.When formulating intervention measures for myopia prevention and control in children, it is advocated to further pay attention to control the distance and duration of near work on weekdays and strengthen screen time management on weekends.

Objective To explore the relationship between traditional Chinese medicine(TCM)constitution,functional connectivity(FC)of the dorsolateral prefrontal cortex(DLPFC),and fluid intelligence in university students to elucidate the mind-body relationship from a modern perspective of TCM.Methods From October 2023 to December 2023,a total of 96 college students of Jiangxi University of Chinese Medicine were included,and Classification and Identification of Constitution in Traditional Chinese Medicine:ZYYXH/T 157-2009,Raven's Advanced Progressive Matrices(RAPM)and resting-state functional near-infrared spectroscopy were used to evaluate TCM constitution,fluid intelligence,and FC of DLPFC.The differences in fluid intelligence between individuals with biased and balanced constitutions were compared using t-tests,and the associations among the TCM Constitution,RAPM score,and the FC between the left and right DLPFC were explored using partial correlation analysis.Results The tendency toward blood-stasis type and a dampness-heat type were positively correlated with the RAPM scores.College students with a tendency toward blood-stasis type exhibited significantly higher RAPM scores than those with a balanced constitution(P＜0.05).Additionally,significant negative correlations were observed between the tendencies toward blood-stasis and yin-deficiency types and the FC of the bilateral DLPFC.In contrast,a significant positive correlation was observed in individuals with balanced constitution tendencies.Conclusion The tendency toward blood-stasis type is associated with fluid intelligence levels and DLPFC functional activity in college students.This finding suggests that students with higher intelligence levels are more likely to exhibit blood-stasis type,highlighting the need for appropriate adjustments and interventions.

Objective To understand the current status of knowledge-attitude-practice(KAP)regarding risk of medication safety behavior among cancer patients in western Yunnan and the related influencing factors,and to provide a basis for conducting rational medication education.Methods Using an approximate random sampling method,a KAP survey on medication safety behavior was conducted among inpatients and outpatients with cancer(aged over 18 years)in multiple hospitals in western Yunnan through online and offline questionnaires.Multiple linear regression analysis was used to explore the impact of different characteristics of the research objects on the KAP scores concerning medication knowledge,behavior,and attitude.Results A total of 512 valid questionnaires were collected.The average scores of medication knowledge,attitude,and behavior among cancer patients were(82.53±23.07),(41.98±8.64),and(67.88±10.08),respectively.Medication knowledge and behavior were at a good level,while medication attitude was at a qualified level.The multiple linear regression results showed that the educational level was a significant influencing factor of the medication knowledge and attitude scores(P＜0.001).Conclusion The overall medication safety among cancer patients in western Yunnan is in a good state,however,there is a need for improvement in medication attitudes.Educational level is the main factor affecting medication safety risk.Pharmacy services should be focused on cancer patients with lower educational levels to enhance their medication safety.

Acute necrotizing encephalopathy（ANE）is a rare post-infectious neurological disease primarily affecting children under 5 years old，with a high mortality and disability rate.Early administration of high-dose glucocorticoids is widely recognized as crucial for optimal efficacy of treatment.However，standardized guidance is lacking，and the optimal dosage as well as timing for administration require validation in larger patient populations.Additionally，combination therapies involving intravenous immunoglobulin，plasmapheresis，tocilizumab，and antiviral treatments may enhance efficacy and reduce mortality rates and neurological sequelae.This review summarized the current application status of high-dose glucocorticoid therapy for ANE in recent years and analyzed the differences in efficacy among different types and doses of glucocorticoids,as well as different timing of administration,with the aim of providing valuable references for optimizing treatment regimens in the future.

Objective:To analyze the correlation between near work, screen time, outdoor time and myopia in children based on objective monitoring technology and to explore the influencing factors related to myopia in children.Methods:A cross-sectional study was conducted.From October 2022 to March 2023, the purposive sampling method was used to select 596 children in Grade 2 and Grade 3 from two primary schools in Shandong Province as study subjects.Eye-Monitor technology of eye-use behavior based on artificial intelligence was used to quantify parameters of near work, screen time and outdoor time.The eye-use behavior parameters were compared within each subject and between non-myopic and myopic children on weekdays and weekends.A multivariate binary logistic regression model was constructed to analyze the influencing factors related to myopia.The study protocol was approved by the Medical Ethics Committee of the Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine (No.HEC-HY-2022023KY).Written informed consent was obtained from the legal guardian of each subject.Results:For each subject, the proportion of near work time on weekdays was greater than on weekends, the proportion of time spent looking at cell phones, computer screens, and outdoor activities was smaller, the duration of single continuous near eye use was longer, the tilt angle of the head in sitting position was greater, and the light intensity was stronger, showing statistically significant differences ( t=19.427, -9.964, -5.916, -10.470, 2.211, 2.898, 15.061; all P<0.05).During weekdays, compared with the non-myopia group, the myopia group had longer total near work duration, longer single continuous near eye use duration, shorter outdoor activity duration, closer eye use distance, larger proportion of near work time, and smaller proportion of outdoor activity time, showing statistically significant differences (all P<0.05).During weekends, compared with the non-myopia group, the myopia group had longer time spent looking at cell phones and computer screens, shorter outdoor activity time, greater proportion of time spent looking at cell phones and computer screens, and smaller proportion of outdoor activity time, with statistically significant differences (all P<0.05).During weekdays, after adjusting for confounding factors, longer single continuous near eye use duration ( OR=1.138, 95% CI: 1.086-1.192, P<0.001) was the risk factor for myopia, and longer working distance ( OR=0.906, 95% CI: 0.847-0.970, P=0.004) and longer outdoor activity time ( OR=0.127, 95% CI: 0.023-0.703, P=0.018) were protective factors for myopia.During weekends, after adjusting for confounding factors, longer time spent on looking at cell phone screens ( OR=2.437, 95% CI: 1.460-4.068, P<0.001) and longer time spent on looking at computer screens ( OR=2.260, 95% CI: 1.283-3.979, P=0.005) were risk factors for myopia, and longer outdoor activity time ( OR=0.624, 95% CI: 0.416-0.934, P=0.022) was the protective factor for myopia. Conclusions:The eyes with continuous near work, prolonged use of smartphone and computer screens, closer eye use distance, and less time spent outdoors have been confirmed to be significantly correlated with myopia based on objective monitoring data.When formulating intervention measures for myopia prevention and control in children, it is advocated to further pay attention to control the distance and duration of near work on weekdays and strengthen screen time management on weekends.

Objective:To compare the efficacy and safety of a domestic hair follicle extraction system versus traditional follicular unit excision (FUE) in extracting hair follicles for the treatment of androgenetic alopecia (AGA) .Methods:A multicenter, randomized, self-controlled clinical trial was conducted on AGA patients aged 18 - 59 years who were recruited from the Huashan Hospital, Fudan University, the Affiliated Hangzhou First People's Hospital, and the China-Japan Friendship Hospital between June 2023 and September 2024. Each patient's scalp was randomly divided into two sides (experimental side vs. control side) using an envelope method. The experimental side underwent robotic hair transplantation with a domestic hair follicle extraction system, and the control side underwent traditional FUE. Hair follicles were extracted from the safe donor area in the occipital region, and implanted into the ipsilateral hair loss area. The primary outcome was the hair transection rate which was calculated immediately after follicular extraction. The secondary outcomes included the hair follicle unit loss rate and the change in hair density at the recipient site on postoperative day 14. Safety was evaluated by assessing the incidence of folliculitis at the donor site on postoperative day 14 and the overall incidence of adverse events. Surgical outcomes were evaluated at 9 months after surgery. Comparisons of evaluation indicators among groups were performed by using a paired t test or Wilcoxon signed-rank test. Results:A total of 55 patients with AGA (51 males and 4 females, aged 32.71 ± 5.75 years) completed the hair follicle transplantation and postoperative follow-up. The hair transection rate ( M[ Q1, Q3]) was 6.65% (4.56%, 10.16%) in the experimental group and 5.28% (3.04%, 8.89%) in the control group (difference = 1.24%, 95% CI: -0.24%, 2.65%) . The hair follicle unit loss rate was 2.00% (1.00%, 3.50%) in the experimental group and 0.50% (0, 2.00%) in the control group, with a significant difference between the two groups ( P = 0.008) . On postoperative day 14, there was no significant difference in the hair density between the experimental group and control group (72.20 ± 25.95 per cm 2vs. 76.49 ± 30.84 per cm 2, P = 0.173) . At 9-month follow-up, both groups showed improvement in the investigator's overall score in the recipient areas. Seven adverse events occurred in 7 subjects (12.72%) in each group, and all were mild folliculitis. Conclusion:The domestic hair follicle extraction system demonstrated comparable efficacy and safety to the traditional FUE in hair transplantation.

Objective To explore the relationship between traditional Chinese medicine(TCM)constitution,functional connectivity(FC)of the dorsolateral prefrontal cortex(DLPFC),and fluid intelligence in university students to elucidate the mind-body relationship from a modern perspective of TCM.Methods From October 2023 to December 2023,a total of 96 college students of Jiangxi University of Chinese Medicine were included,and Classification and Identification of Constitution in Traditional Chinese Medicine:ZYYXH/T 157-2009,Raven's Advanced Progressive Matrices(RAPM)and resting-state functional near-infrared spectroscopy were used to evaluate TCM constitution,fluid intelligence,and FC of DLPFC.The differences in fluid intelligence between individuals with biased and balanced constitutions were compared using t-tests,and the associations among the TCM Constitution,RAPM score,and the FC between the left and right DLPFC were explored using partial correlation analysis.Results The tendency toward blood-stasis type and a dampness-heat type were positively correlated with the RAPM scores.College students with a tendency toward blood-stasis type exhibited significantly higher RAPM scores than those with a balanced constitution(P＜0.05).Additionally,significant negative correlations were observed between the tendencies toward blood-stasis and yin-deficiency types and the FC of the bilateral DLPFC.In contrast,a significant positive correlation was observed in individuals with balanced constitution tendencies.Conclusion The tendency toward blood-stasis type is associated with fluid intelligence levels and DLPFC functional activity in college students.This finding suggests that students with higher intelligence levels are more likely to exhibit blood-stasis type,highlighting the need for appropriate adjustments and interventions.