Objective To study the effect of incorporating comprehensive geriatric assessment(CGA)into the whole-process WeChat-based case health management in elderly population who took annual physical examinations,thereby to improve their ability in health self-management.Methods A randomised controlled trial was conducted to select 100 elderly people who took annual physical examinations in our hospital from July 2022 to June 2023.The elderly were randomly divided into a control group and an trial group,with 50 people per group.CGA was applied to both groups,but the control group was under conventional health management,while the trial group received the incorporation of CGA into a whole-process WeChat-based case health management.The self-rated abilities for health practices scale(SRAHP)was used to compare the scores between the two groups before intervention,at 3,6 and 12 months after intervention.The scores of fatigue,resistance,ambulation,illnesses&loss of weight scale(FRAIL)and the mini nutritional assessment-short form(MNA-SF)were compared between the two groups before intervention and at 12 months after intervention.Incidence of falls was also evaluated after intervention.Results All the participants completed the study.Repeated measures analysis of variance showed that total SRAHP scores had statistical significances in main effect on time,group and interaction(Ftime=193.451,P<0.001;Fgroup=23.661,P<0.001;Finteraction=29.970,P<0.001).Further analysis revealed that the elderly in trial group had higher total scores in SRAHP than those in the control group at 6 and 12 months after intervention(both P<0.001).At 12 months after intervention,the trial group showed better scores in FRAIL and MNA-SF than the control group(both P<0.05)as well as with a lower incidence of falls(P<0.05).Conclusion Incorporation of CGA into a comprehensive WeChat-based case health management,over a long-term,can effectively enhance the ability in health self-management among elderly individuals who take annual health examinations,improve frailty and nutritional status and reduce the incidence of falls.The health self-management discovered from this study provides a valuable reference for health management among the elderly people who take annual physical examinations.

Objective To study the effect of incorporating comprehensive geriatric assessment(CGA)into the whole-process WeChat-based case health management in elderly population who took annual physical examinations,thereby to improve their ability in health self-management.Methods A randomised controlled trial was conducted to select 100 elderly people who took annual physical examinations in our hospital from July 2022 to June 2023.The elderly were randomly divided into a control group and an trial group,with 50 people per group.CGA was applied to both groups,but the control group was under conventional health management,while the trial group received the incorporation of CGA into a whole-process WeChat-based case health management.The self-rated abilities for health practices scale(SRAHP)was used to compare the scores between the two groups before intervention,at 3,6 and 12 months after intervention.The scores of fatigue,resistance,ambulation,illnesses&loss of weight scale(FRAIL)and the mini nutritional assessment-short form(MNA-SF)were compared between the two groups before intervention and at 12 months after intervention.Incidence of falls was also evaluated after intervention.Results All the participants completed the study.Repeated measures analysis of variance showed that total SRAHP scores had statistical significances in main effect on time,group and interaction(Ftime=193.451,P<0.001;Fgroup=23.661,P<0.001;Finteraction=29.970,P<0.001).Further analysis revealed that the elderly in trial group had higher total scores in SRAHP than those in the control group at 6 and 12 months after intervention(both P<0.001).At 12 months after intervention,the trial group showed better scores in FRAIL and MNA-SF than the control group(both P<0.05)as well as with a lower incidence of falls(P<0.05).Conclusion Incorporation of CGA into a comprehensive WeChat-based case health management,over a long-term,can effectively enhance the ability in health self-management among elderly individuals who take annual health examinations,improve frailty and nutritional status and reduce the incidence of falls.The health self-management discovered from this study provides a valuable reference for health management among the elderly people who take annual physical examinations.

Objective:To study the efficacy of ademetionine 1,4-butanedisulfonate enteric coated tables in the treatment of severe intrahepatic cholestasis in gestation period and its influence on liver function. Methods:From July 2013 to November 2014 in our hos-pital, 122 cases of severe intrahepatic cholestasis patients were divided into the observation group (61 cases) and the control group (61 cases) according to the admission order. The two groups of patients were given the conventional treatment, and the observation group was treated with ademetionine 1,4-butanedisulfonate enteric coated tables additionally. The clinical efficacy, pruritus, perinatal child and pregnancy outcomes were observed after the treatment. The liver function in the two groups before and after the treatment was com-pared. Results:Before the treatment, TB, TBA, DB, AST and ALT in the two groups showed no significant difference (P>0. 05). After the treatment, TB[(22.7 ±4.3) μmol·L-1], TBA [(14.3 ± 3.4) μmol·L-1], DB[(5.3 ± 0.8)μmol·L-1], AST [(73.2 ±13.2)U·L-1] and ALT [(82.5 ±10.3)U·L-1] in the observation group were significantly lower than those in the con-trol group[TB(28.3 ±4.8) μmol·L-1, TBA(21.5 ±5.2) μmol·L-1, DB(8.3 ±2.4) μmol·L-1, AST(245.1 ±38.3) U· L-1, ALT(221.4 ±37.4) U·L-1], and the difference was statistically significant(P<0.05). After the treatment, the total effec-tive rate in the observation group (96. 72%) was significantly higher than that in the control group (80. 33%), the degree of itching in the observation group was significantly lower than that in the control group, the perinatal children and pregnancy outcomes in the ob-servation group were significantly better than those in the control group, and the difference was statistically significant (P<0. 05). Conclusion:Ademetionine 1,4-butanedisulfonate enteric coated tables in the treatment of severe intrahepatic cholestasis during preg-nancy is effective with high security, which can significantly improve liver function, and is worthy of wide application.