1.Pregnancy-related Guillain-Barré syndrome: A Case Series
Diah Kurnia Mirawati ; Subandi Subandi ; Baarid Luqman Hamidi ; Dody Wahyu Lestya Nugraha ; Aiman Hilmi Asaduddin ; Maulana Firdaus Syahrizal ; Stefanus Erdana Putra ; Muhammad Hafizhan
Malaysian Journal of Medicine and Health Sciences 2024;20(No.1):383-388
Introduction: Pregnancy-related Guillain-Barré syndrome (GBS) is a rare autoimmune disorder that affects pregnant
women. With an annual incidence ranging from 0.81 to 1.89 cases per 100,000 population, GBS can occur at any
trimester of pregnancy, as well as during the postpartum period are susceptible to GBS. The pillars of managing
pregnancy-related GBS to improve outcomes include early diagnosis, prompt immune-modulatory therapy, and multidisciplinary input. Case Series: In this study, three case of GBS in pregnancy were reported. The first patient was a
35-year-old woman, G3A1P2 post emergency Transperitoneal Cesarean Section (TPCS), who experienced with lower limb weakness three days before TPCS. After being diagnosed with severe eclampsia and underwent emergency
TPCS, her complaint of lower limb weakness worsened. The second patient, a 27-year-old woman, with G2P1A0
experienced weakness in all four limbs. The third patient, a 20-year-old woman with G1P0A0, in the third semester
presented with weakness in all four limbs. The electroneurography investigation conducted on these patients supported the diagnosis of GBS, which was subsequently managed with plasma exchange (PE). After the administration
of PE, there was observed improvement in the clinical manifestation of GBS. Conclusion: The development of GBS
in pregnancy is typically preceded by bacterial or viral infection. Preeclampsia was found to be associated with two
folds risk of GBS, which was usually diagnosed based on the neurological examinations with supportive studies, including serological tests, cerebrospinal fluid analysis and electroneurography. The management of pregnancy-related
GBS included intravenous immunoglobulin, PE, physiotherapy, and supportive therapy, such as ventilator support.
2.Associated Factors of Growth With the Prevalence of Adolescent Idiopathic Scoliosis Among Female Primary School Children in Kuala Langat
Aisha Mohd Din ; Amir Muhriz Abdul Latiff ; Nurul Nadia Subandi
Malaysian Journal of Medicine and Health Sciences 2021;17(No.4):273-283
Introduction: Scoliosis is a deformity of the spine that presents with a ‘S’ or ‘C’ curve with the most common type
called Adolescent Idiopathic Scoliosis (AIS). The deformity begins unnoticed and can rapidly progress into severe
deformation during the adolescent’s growth spurt. Factors such as onset of puberty, dietary intake, physical activity
and ethnicity contributes to the development of AIS. Therefore, this study aims to determine the association of these
factors with the prevalence of AIS among female school children in Kuala Langat. Methods: A total of 374 students
between age 10 and 12 from six different primary schools in Kuala Langat were recruited according to the inclusion criteria. Consent form and questionnaire was distributed to the student’s parents/guardian prior conducting the
research. Adam’s Forward Bend Test was performed to measure the rotation of the trunk using a smartphone Scoliometer Application. Results:Out of 374 students, 21 students from schools in Kuala Langat were found positive for
AIS with a prevalence rate of 5.6%. However, no association was seen between the student’s age of menarche, dairy
intake, frequency in physical activity and ethnicity with the prevalence of AIS. Conclusion: The factors measured in
this study showed no association with the prevalence of AIS among school children in Kuala Langat.


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