Meta-IMU: A R Shiny App to Conduct Meta-Analysis in Systematic Review and Umbrella Reviews Many tools exist for conducting meta-analyses in systematic reviews, but they are often expensive or difficult for beginners to use. This challenge arises because most tools either fail to address all aspects of meta-analysis comprehensively or lack sufficient guidance for navigating their features. To address these limitations, we developed Meta-IMU, a free R-based Shiny application tailored specifically for beginners. Unlike many existing tools that focus solely on standard systematic reviews, Meta-IMU supports both systematic reviews and umbrella reviews, offering a more versatile approach. To ensure accessibility, Meta-IMU includes built-in instructional videos that guide users step by step, from navigating the application to interpreting the results produced. This guidance ensures users can confidently perform analyses without prior expertise. Meta-IMU encompasses a comprehensive range of features covering key aspects of meta-analysis, such as defining review questions, developing search terms, retrieving studies from various databases, assessing risk of bias, creating tables and plots, analysing small-study effects, performing meta-regression and subgroup analyses, conducting sensitivity analyses, assessing the certainty of evidence, summarizing findings, and generating PRISMA checklist reports. By integrating these functionalities into a single platform, Meta-IMU provides a user-friendly, all-in-one solution. In summary, Meta-IMU is a comprehensive, free application designed to simplify the process of meta-analysis for both systematic reviews and umbrella reviews, making advanced analytical techniques accessible to researchers at any level of experience.

This survey was performed to analyze the usability of the third edition of the Korean breast cancer clinical practice guidelines (KBCCPG) in clinical practice. We made a questionnaire composed of 18 general and 82 specific questions regarding benign breast disease (B; 1 question); non-invasive disease (N; 12 questions); early-stage disease (E; 26 questions); advanced disease (A; 24 questions); and metastatic (M) breast cancer-related problems (19 questions). A total of 100 questionnaires, with a link to an online survey, were delivered via e-mail to over 700 members of the Korean Breast Cancer Society (KBCS), and associated academy members, over 20 days between 26th February and 16th May 2010. Out of 270 respondents who read the e-mail, 96 answered the questionnaire. Participants included 87 surgical oncologists, 5 radiation oncologists, 2 oncoplastic surgeons, 1 pathologist, and 1 medical oncologist. The third KBCCPG were perceived as differing from the second guidelines in terms of the level of clinical evidence required before choosing a recommendation. For the progress of the KBCCPG, the guideline committee should try to reinforce all courses of guideline development with several elements including data from clinical trials of Korean breast cancer patients, securing a multidisciplinary approach, developing consistent and reasonable processes for each step of the revision of the guidelines, induction of liberal scientific and ethical discussion about all issues with all KBCS members. The cost-effectiveness of healthcare and the logical development of the KBCCPG would also be ensured. Timely updates of the clinical guidelines for breast cancer treatment are essential to facilitate optimal decision-making in daily practice, and to ensure adequate patient feedback.
Aluminum Hydroxide ; Breast ; Breast Diseases ; Breast Neoplasms ; Carbonates ; Surveys and Questionnaires ; Delivery of Health Care ; Dietary Sucrose ; Electronic Mail ; Humans ; Korea ; Logic