Objective To explore the relationship between different vaginal community state type(CST)and preterm birth during pregnancy.Methods Retrieved from PubMed,Web of Science,Elsevier Science Direct,CNKI,Wanfang Data Knowledge Service Plat-form and VIP database for published literature on the relationship between vaginal CST and preterm birth from the establishment of the da-tabase to June 2024.References were screened according to inclusion and exclusion criteria and information was extracted.The obtained data were statistically analyzed using Revman 5.4 and Stata 16.0software.Results A total of 13 cohort studies were included,involving a total of 1959 pregnant women,involving 5 vaginal CST identified by 16SrRNA high-throughput gene sequencing analysis.Four of which were dominated by Lactobacillus,they were CST Ⅰ curled Lactobacillus,CST Ⅱ Graveli Lactobacillus,CST Ⅲ inert Lactobacillus and CST V Jenner Lactobacillus.The other one was CST Ⅳ low Lactobacillus.The results of network Meta-analysis showed that the risk of preterm birth induced by each CST was ranked from highest to lowest as CST Ⅴ＞CST Ⅳ＞CST Ⅲ＞CST Ⅱ＞CST Ⅰ,and there was no statistically significant difference in the risk of preterm birth caused by each CST.In the early pregnancy sampling group(sampling gestational age＜14 weeks),CST Ⅳ increased the risk of preterm birth compared with CST Ⅰ,and the difference was statistically signif-icant(P＜0.05).In the Asian population,the highest risk of bacteria causing preterm birth was ranked as CST Ⅴ＞CST Ⅱ＞CST Ⅳ＞CST Ⅰ＞CST Ⅲ,and there was no statistically significant difference among the CST groups.Conclusion The current study showed that there was no statistically significant difference in the risk of preterm birth caused by various types of vaginal CST during the whole pregnan-cy,but subgroup analysis showed that CSV Ⅳ increased the risk of preterm birth compared with CST Ⅰ in early pregnancy,and the difference was statistically significant.Sampling gestational age and race may influence the results of the study,and more high-quality and large sample studies are needed to explore the relationship between vaginal CST and preterm birth.

Objective To explore the relationship between different vaginal community state type(CST)and preterm birth during pregnancy.Methods Retrieved from PubMed,Web of Science,Elsevier Science Direct,CNKI,Wanfang Data Knowledge Service Plat-form and VIP database for published literature on the relationship between vaginal CST and preterm birth from the establishment of the da-tabase to June 2024.References were screened according to inclusion and exclusion criteria and information was extracted.The obtained data were statistically analyzed using Revman 5.4 and Stata 16.0software.Results A total of 13 cohort studies were included,involving a total of 1959 pregnant women,involving 5 vaginal CST identified by 16SrRNA high-throughput gene sequencing analysis.Four of which were dominated by Lactobacillus,they were CST Ⅰ curled Lactobacillus,CST Ⅱ Graveli Lactobacillus,CST Ⅲ inert Lactobacillus and CST V Jenner Lactobacillus.The other one was CST Ⅳ low Lactobacillus.The results of network Meta-analysis showed that the risk of preterm birth induced by each CST was ranked from highest to lowest as CST Ⅴ＞CST Ⅳ＞CST Ⅲ＞CST Ⅱ＞CST Ⅰ,and there was no statistically significant difference in the risk of preterm birth caused by each CST.In the early pregnancy sampling group(sampling gestational age＜14 weeks),CST Ⅳ increased the risk of preterm birth compared with CST Ⅰ,and the difference was statistically signif-icant(P＜0.05).In the Asian population,the highest risk of bacteria causing preterm birth was ranked as CST Ⅴ＞CST Ⅱ＞CST Ⅳ＞CST Ⅰ＞CST Ⅲ,and there was no statistically significant difference among the CST groups.Conclusion The current study showed that there was no statistically significant difference in the risk of preterm birth caused by various types of vaginal CST during the whole pregnan-cy,but subgroup analysis showed that CSV Ⅳ increased the risk of preterm birth compared with CST Ⅰ in early pregnancy,and the difference was statistically significant.Sampling gestational age and race may influence the results of the study,and more high-quality and large sample studies are needed to explore the relationship between vaginal CST and preterm birth.

Objective To investigate the risk factors of cerebral infarction in elderly patients with type 2 diabetes mellitus.Methods Elderly patients with type 2 diabetes complicated with cerebral infarction from August 2014 to March 2016 in our hospital were selected as observation group of 70 cases, elderly patients with type 2 diabetes alone of 70 cases as control group.The related indicators were compared between two groups, then the indicators with statistical difference were included into the multiple Logistic aggression analysis.Results There were significant difference between two groups of waist to hip ratio (WHR), body mass index (BMI), fasting blood glucose (FBG), 2h postprandial blood glucose (2h PBG), fasting insulin (FINS), glycosylated hemoglobin (HbA1C), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C).The multiple Logistic aggression analysis showed BMI,TG,LDL-C,FINS,2hPBG and WHR were risk factors in elderly type 2 diabetes mellitus complicated with cerebral infarction. Conclusion There are many risk factors in elderly patients with type 2 diabetes complicated with cerebral infarction, higher blood sugar, higher blood lipid and higher body mass index as the independent risk factors, which should be payed attention to and prevent the occurrence of cerebral infarction.

Objective To investigate the effect of aspirin combined with atorvastatin in the treatment of diabetic atherosclerosis.Methods 120 patients with diabetic atherosclerosis form August 2014 to February 2016 were selected,and randomly divided into treatment group and control group,60 cases in each group.Control group treated with aspirin enteric-coated tablets,the treatment group treated with aspirin enteric-coated tablets combined with atorvastatin,comparing the two groups before and after treatment of fasting blood glucose,blood lipid related index,carotid intima-media thickness and plaque thickness,and the adverse reactions.Results After treatment, the levels of fasting blood glucose and fasting insulin in treatment group were significantly lower than control group(P<0.05),the carotid intima-media thickness and plaque thickness in treatment group was significantly lower than control group(P<0.05).The levels of TG,TC,LDL-C and HDL-C in treatment group were significantly improved(P <0.05).Conclusion Aspirin enteric coated tablets combined with atorvastatin efficacy significantly in the treatment of diabetic atherosclerosis.