Background: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by the accumulation of surfactant within the alveoli, leading to impaired gas exchange and respiratory insufficiency. Although the disease is uncommon, it significantly affects patients’ quality of life and requires specific diagnostic and therapeutic approaches. Whole lung lavage (WLL) is considered the standard treatment; however, it has not been widely implemented in Mongolia. We report the first successful case of WLL performed for PAP in Mongolia. Case Presentation: A 56-year-old male presented with dyspnea. Chest computed tomography demonstrated a bilateral “crazy paving” pattern. Bronchoalveolar lavage fluid was positive for periodic acid–Schiff (PAS) staining, and anti–GM-CSF antibodies were detected, confirming the diagnosis of PAP. WLL was performed under general anesthesia using a double-lumen endotracheal tube with bronchoscopic guidance. One lung was ventilated with 100% oxygen while the contralateral lung was sequentially lavaged with 800–1000 mL of warm (37°C) saline per cycle until the effluent became clear. A total of approximately 20 liters of saline was used. Result: The procedure was completed successfully without complications. Following treatment, the patient showed marked clinical improvement with reduced dyspnea and increased exercise tolerance. Oxygen saturation improved from 88% to 93%, and spirometric parameters (FVC, FEV₁) demonstrated improvement. Chest imaging revealed a reduction in pulmonary opacities. Conclusion This case demonstrates the successful implementation of whole lung lavage (WLL) in Mongolia and highlights its importance in improving the diagnostic and therapeutic capacity for rare pulmonary diseases such as pulmonary alveolar proteinosis. The procedure resulted in significant improvement in clinical, functional, and radiological parameters, consistent with findings from international studies. Early diagnosis of PAP and the adoption of standardized protocols in accordance with international guidelines are essential to optimize treatment outcomes and enhance patients’ quality of life.

Background: Between 2017 and 2021, the prevalence of obesity among children aged 2-19 years reached 19.7%, affecting approximately 14.7 million children, with rates of 12.7% among those aged 2-5 years and 22.2% among those aged 6-11 years. Globally, dental caries is among the most common non-communicable diseases, often leading to pain, infection, tooth loss, and reduced quality of life. In Mongolia, the prevalence of overweight and obesity among children and adolescents has increased markedly since 2010, beginning at an early age. In 2018, one in six children under five years and one in eight adolescents were overweight. Aim: This study aimed to assess selected non-communicable disease risk factors among children and adolescents. Materials and Methods: A cross-sectional study was conducted in Ulaanbaatar, Mongolia, using Family Health Centers across all nine districts. A total of 622 children aged 6–17 years were included. Anthropometric measurements (weight, height, and waist circumference) were obtained, and body mass index (BMI) was calculated. Oral health examinations were performed to determine the Decayed, Missing, and Filled Teeth (DMFT) index. Nutritional status was classified based on age and sex-specific growth charts into normal weight, overweight, and obesity categories. Results: Among the participants, 10.29% (n=64) were overweight and 9.97% (n=62) were obese. Overweight was more prevalent among girls, whereas obesity was relatively higher among boys (p<0.001). Regarding dental caries, 37.6% (n=234) of participants had no caries (DMFT=0), 48.1% (n=299) had mild caries (DMFT=1-2), and 14.3% had moderate to severe caries (DMFT≥3). The overall prevalence of dental caries was 62.38%, with significant variation by age group: highest in children aged 6-9 years (69.9%) and lowest in those aged 15-17 years (46.1%) (p<0.001). No statistically significant association was found between BMI categories and dental caries status. Although normal weight predominated in the DMFT=0 and DMFT=1-2 groups, logistic regression adjusted for age and sex showed no significant relationship between BMI and dental caries. However, children aged 6-9 years had a significantly higher likelihood of having dental caries compared to those aged 15-17 years (OR=0.39, 95% CI: 0.24-0.63, p<0.001). Conclusions 1. Among the risk factors for non-communicable diseases (NCDs), overweight and obesity were highly prevalent among children, with one in every five children classified as overweight or obese. The prevalence among male children was approximately two times higher than that among female children (p<0.001). 2. The prevalence of dental caries among the study participants was 90.7%, with a mean caries intensity of 6.4, indicating high level of severity. Age-group analysis demonstrated that children aged 6–10 years exhibited the highest prevalence and severity of dental caries, with a prevalence of 93.5% and a mean caries intensity of 7.3.

Background: The learning outcomes of a program are defined by the knowledge, skills, and attitudes that students are expected to acquire by the end of the curriculum. For occupational therapy professionals, it is essential to successfully implement both pre-graduation and post-graduation programs and to assess the effectiveness of the curriculum by clearly identifying the competencies expected of graduates in society. Aim: To identify the core competencies required for training occupational therapists at both pre-graduation and post-graduation levels. Materials and Methods: A modified Delphi method combined with Nominal Group Technique (NGT) was employed. The study was conducted in three phases from April 2022 to May 2024. In the initial online survey, a total of 83 participants were involved, including occupational therapy students, graduates, and members of the Mongolian Association of Occupational Therapists. A nominal group consisting of four experts held several focus group discussions to review and vote on the proposed competencies, forming a revised list. In the final phase (second-round Delphi), the updated list was distributed online again to collect additional feedback. Results: A total of 136 individuals participated in the online surveys throughout the study. The final list of competencies was synthesized based on three main international standards: the World Federation of Occupational Therapists (WFOT) Minimum Standards for Education (2016), the Canadian Association of Occupational Therapists (CAOT) Profile of Occupational Therapy Practice (2012), and the TUNING Educational Competencies in Europe. Through five rounds of NGT meetings, one online scoring session, and a final Delphi round, a total of 12 program learning outcomes (PLOs), 198 core competencies for the pre-graduation level, and 86 competencies for the post-graduation level were identified. Conclusion By applying consensus techniques, we developed a structured list of core competencies at both the basic and advanced levels aligned with the 12 program learning outcomes (PLOs) of the occupational therapy curriculum. This list can serve as a practical reference framework for future curriculum design and professional training programs in the occupational therapy.

Background: Since ancient times, humans have used medicinal plants for medicinal purposes, and they have been recognized as beneficial to health. The basis of the treatment of these plants is phytochemical substances and in modern times, with the development of science and technology, the substances contained in these plants are extracted and medicinal substances and drugs are produced to treat many diseases. There are more than 800 medicinal plants in Mongolia, and their chemical structure and properties are studied in detail, biological activity and main features are discovered, and new medicines are produced. From the Thalictrum squarrosum plant, 25 compounds have been identified, such as triterpenoids with 17 carbon atoms in the cycloartane type ring, saponins, oleic acid glycosides, phytosterols and their glycosides etc., and the structures of 7 new compounds have been determined and the research on phenolic compounds and antioxidant activity has been limited, which is the basis for this research. Aim: Determination of total phenolic content and antioxidant activity of Thalictrum squarrosum. Materials and Methods: Total phenolic compounds were determined spectrophotometrically using Folin-Chicolte color reagent in 1.0 raw material of the Thalictrum squarrosum. Antioxidant activity was determined by DPPH, FRAB and ABTS in sub-extracts of 4 groups. Results: The total phenolic compounds of Thalictrum squarrosum were determined to be 1.9±0.001%. In the study of biological activity of Thalictrum squarrosum plants, the antioxidant activity of 4 groups of sub-extracts was tested by DPPH method, and the IC50 of total alkaloids (pH 9-10) was 201.58±0.1 μg/ml, ethyl acetate sub-extract 94.34±0.66 μg/ml, aqueous extract 824.18±0.08 μg/ml, and butanol sub-extract 128.75±0.58 μg/ml. When tested by ABTS method, the IC50 of total alkaloids (pH 9-10) was 35.83±0.44 μg/ml, ethyl acetate sub-extract 90.45±0.62 μg/ml, aqueous extract 104.19±0.93 μg/ml, dichloromethane sub-extract 156.44±0.48 μg/ml, and butanol sub-extract 170.03±0.61 μg/ml. When tested for antioxidant activity at 800 μg/ml by the FRAB method, the ethyl acetate sub-extract was 8946.16±14.79 μg/ml, the dichloromethane sub-extract was 1670.12±39.28 μg/ml, the butanol sub-extract was 4863.97±25.98 μg/ml, and the total alkaloids (pH 9-10) were 4897.99±58.12 μg/ml. Conclusion The ethyl acetate extract of the plant Thalictrum squarrosum has been found to be highly antioxidant active and total phenolic compound was 1.9±0.001%.

Background: The annual incidence of pulmonary thromboembolism is reported to be 39–115 cases per 100,000 population, with rates of 60–120/100,000 in Western countries and 10–20/100,000 in Asian countries. In Mongolia, few studies revealed the prevalence of risk factors and clinical manifestations of acute pulmonary embolism. Over the past 30 years, the incidence of risk factors for non-communicable diseases, which are mainly triggered by lifestyle and social parameters, has rose. Moreover, environmental conditions such as cold climate, hypoxia, and blood hyperviscosit may contribute to higher incidences of acute pulmonary embolism in high-altitude regions. This condition is potentially fatal and can become impair quality of life. Aim: We aimed to compare risk factors and clinical characteristics based on age and sex, and to evaluate laboratory findings and diagnostic tests among Mongolian patients diagnosed with acute pulmonary embolism. Materials and Methods: This retrospective research included total 232 patients meeting inclusion criteria. The information was collected from patient histories, including general demographics, risk factors, comorbidities, symptoms, and physical examination findings. Laboratory analyses included complete blood count, coagulation profile, and immunological markers (D-dimer, NT-proBNP, troponin, protein C, homocysteine, and C-reactive protein), as well as selected imaging parameters. We used Wells and Geneva scoring systems to assess probability of acute pulmonary embolism and Pulmonary Embolism Severity Index to determine disease severity. Differences by age and sex were analyzed using independent t-tests for continuous variables and chi-square tests for categorical variables. Results: Among participants with acute pulmonary embolism, the prevalence of tobacco and alcohol use was significantly higher among males (p<0.001). Among comorbidities, arterial hypertension and other pulmonary diseases were more common in males, whereas cardiac diseases were more frequent in females (p=0.028). Participants aged 65 years and older showed higher rates of comorbid conditions and regular medication use (p<0.001). The most common symptoms were dyspnea (90.9%), chest pain (74.2%), cough (70.5%), leg pain (38.9%), hemoptysis (20.7%), and cyanosis (9.3%). According to sPESI scoring, 69.8% (n=162) were at high risk of death within 30 days, with no significant difference by sex. However, mortality risk within 30 days was significantly higher in participants aged 65 years and above (p<0.001). As increasing age, the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were elevated, indicating an acute inflammatory response (p=0.001). Contrast-enhanced CT scans revealed that 95 participants (44.2%) had main pulmonary artery involvement, with no significant sex difference, though involvement of the main pulmonary artery was more frequent in those aged 65 and older. Conclusion Dyspnea, chest pain, and cough were the most common symptoms among patients diagnosed with acute pulmonary embolism. The 30-day mortality risk associated with it was higher among males and increased with advancing age.

Abstract Chloroformic fraction from the aerial parts of Bassia dasyphylla (fisch. et mey.) ktze. growing in Mongolia have been studied by means of Gas Chromatography Mass spectrometry method. Benzyl alcohol, phenol 2-methoxy, 2-methoxy-4-vinylphenol, 2-propenoicacid, 3- (2-hydroxyphenol)-,(E), Ibuprofen methyl ester, 3’,5’-dimethoxyacetophenone, 3-hydroxy-β-damascone, megastigmatrienone, 5-hydroxy-7-methoxy-2-(p-methoxyphenyl) -6,8-dimethyl-4-chromanon 18 compounds were determined and found for the first time from this plant species.

Introduction: Now days in case of two countries’ cooperation has been developing day by day, diversified activities such as collaboration and exchanging experience has been performing in health sector, medical science, besides pharmacology. Methods: This study aimed to compare two countries’ pharmacist’s acquirements and roles and provide information to Mongolian Pharmaceutical Universities and pharmacist students. Pharmaceutical: Statistics :
Population:
  - 3 million in Mongolia
  - 5 million in Korea
Number of pharmacists:
  - 1726 (by 2016) in Mongolia
  - 33182 (by 2016) in Korea
Number of Pharmaceutical Universities
  - 7 universities, including 1 public and 6 private in Mongolia
  - 34 universities, including 10 public and 25 private in Korea Results As a result of this study, pharmacist’s acquirements, role and working sectors of pharmacists in two countries are ordinarily same. There are some different sides below:
  • Period of pharmacist’s preparatory training is 5 years at university in Mongolia and 2+4 years in Korea.
  • Pharmaceutical Universities of Mongolia trains 2 specialists: pharmacist (bachelor`s degree) and pharmacist (diplom`s degree); College of Pharmacy of Korea trains pharmacist, pharmacist of traditional medicine and pharmaceutical engineering.
  • For a role of business, in Mongolia pharmacist (diplom`s degree) is a separate specialist trained with diploma, whereas in Korea, if pharmacist gets a license, they have a right to compound a medicine legally, but commonly in pharmaceutical industry.
  • As for sector, pharmacists are trained in many specializes, such as general pharmacist, clinical pharmacist, military pharmacist, nuclear pharmacist, cancer pharmacist and vet pharmacist.
  • Special legal professional pharmacists work in Korea, such as governmental organization’s pharmacist, civil service pharmacist and public organization’s pharmacist.
  • No person, other than pharmacists or oriental pharmacists may dispense drugs, and pharmacists or oriental pharmacists shall dispense drugs within the limit of the license, respectively: However, students who major in pharmacy at college may dispense drugs within the limits prescribed by Ordinance of the Ministry of Health and Welfare.

BACKGROUND: According to the World Health Organization (WHO), 10-15% of couples of reproductive age have infertility. According to researcher D. Sukhe (1999), hormonal infertility in the reproductive age of women was 33.6%, which was a large part of the cause of infertility. In recent years, the number of cases of endocrine disorders, including malignancy and sexually transmitted infections, has been increasing year by year. According to WHO reports, thyroid disorders have a prevalence of 49.3% for active reproductive age (30-50). According to the report of the Health Development Center in 2016, since the thyroid disorders are the second most common disease in endocrine gland disease, our study found that the infertility in reproductive age of women can be substantial due to the loss of thyroid gland. METHODS: The study was carried out by the couple of 20-45 year-olds and modeled as an analytical study model. The questionnaire was used for the couple’s interviews and some of the measurement of body and serum use of TOSOH Corporation AIA-360, Tokyo, Japan. On the serum, anti-TPO and аnti-TG carbohydrates are identified by the Cobas e-411 analyzer under the manufacturer’s accompanying protocol. RESULTS: 76.7% of women were diagnosed with infertility euthyroid, 0.7% hyperthyroidism, 22.6% hypothyroidism (3.8% with overt hypothyroidism and 18.8% subclinical hypothyroidism). Prevalence of TAI, in 6.7% isolated positive anti-Tg were found, and 14.3% had isolated positive TPO, In 3.7% of cases, both types of autoantibodies were present. We analysed binary logistic regression for anti-TPO and anti-TG autoantibody in the positive and negative group in past obstetrics history, evidence of positive of anti-TPO and anti-Tg was increased risk of miscarriage 2.2 times (OR = 2.2, p <0.01). CONCLUSIONS: Women with disorders in our study have high percentage of subclinical hypothyroidism and have higher rate of thyroid autobodies in serum which may be a problem for women with infertility and pregnancy complications due to the loss of thyroid gland. There is a need to develop a principle of recovery and treatment.

The identification of individuals of predominant Rlung, Mkhis, badgan symbolic code quantativeratiotypes were carried out by our coworkers, a preliminary assessment of constitution type was carried out on a total of 81 volunteers, using subjective assessment and a screening questionnaire, many individuals were heterogeneous constitution type. Individuals with rlung symbolic code in the third compartment, consisting of visceral-alpha 10% fats and subcutaneous alpha 30% fats (the form of decrease of both visceral-alpha 10% fats and subcutaneous alpha 30% fats) were distinguished by more high value of redoxypontials i.e. in individuals with rlung symbolic code in the fourth compartment the contents of visceral-alpha 10% fats and subcutaneous alpha 30% fats were decreased in 1,73 fold and value of membrane MDA were increased in 2,57 fold, which are indicator of slowing of H+, e- flow because of relatively shortage of H+, e- donators and H+, e- acceptors. Individuals with badgan symbolic code in the third compartment, consisting of visceral-alpha 10% fats and subcutaneous alpha 30% fats (the form of increase of both visceral-alpha 10% fats and decrease of and subcutaneous alpha 30% fats) were distinguished by relatively high value of membrane MDA i.e. in individuals with badgan symbolic code in the third compartment the ratio of visceral-alpha 10% fats and subcutaneous alpha 30% fats were increased in 1,12 fold and value of membrane MDA were increased in 2,57 fold, which are indicator of slowing of H+, e- flow because of relatively shortage of H+, e- acceptors with relatively accumulation of H+, e- donators in the second compartment, consisting of serum glucose, LPHD, LPLD, Individuals with mkhris symbolic code in the third compartment, consisting of visceral-alpha 10% fats and subcutaneous alpha 30% fats (the form of decrease of both visceral-alpha 10% fats and increase of and subcutaneous alpha 30% fats) were distinguished by relatively low value of membrane MDA i.e. in individuals with mkhris symbolic code in the fourth compartment the ratio of visceral-alpha 10% fats and subcutaneous alpha 30% fats were decreased in 1,04 fold and value of membrane MDA were decreased in 1,48 fold, which are indicator of intensifying of H+,e- flow because of relatively optimal concentration of H+,e- acceptors with relatively rapid utilization of H+, e- donators in the second compartment, consisting of LPHD, LPLD, AO-SPOL.

The one of advantages, new events, appeared at lasttime in the integration part of Traditional and Modern medicine is attempt, proposed by prof. M.Ambaga, which essence is devoted to how to transform a all disordered knowledge accumulated in the field of medical science in a ordered more understandable form as new definition of living cells, the new conception of describing of human body by 4 compartments. The electron transport chain still functions to pump hydrogen ions into the intermembrane space, but the coupling of the proton gradient to ATP production is rendered impossible by DNP. As a result, ATP production is dramaticallyreduced, and the energy is instead thrown off as heat. DNP is lipophilic weak acids that therefore readily pass through membranes, they bind protons in the acidific side of the membrane-intermembrane spaces, diffuse through, and release them on the alkaline side-matrix side, thereby dissipating the proton gradient, metabolic rate is increased. Rotenone inhibits the oxidation of NADH to NAD, blocking the oxidation byNAD of substrates such as glutamate, alpha-ketoglutarate, and pyruvate. Rotenone inhibits the mitochondrial respiratory chain between diphosphopyridine nucleotide and flavine.