1.Genome-wide DNA methylation and mRNA transcription analysis revealed aberrant gene regulation pathways in patients with dermatomyositis and polymyositis.
Hui LUO ; Honglin ZHU ; Ding BAO ; Yizhi XIAO ; Bin ZHOU ; Gong XIAO ; Lihua ZHANG ; Siming GAO ; Liya LI ; Yangtengyu LIU ; Di LIU ; Junjiao WU ; Qiming MENG ; Meng MENG ; Tao CHEN ; Xiaoxia ZUO ; Quanzhen LI ; Huali ZHANG
Chinese Medical Journal 2025;138(1):120-122
2.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
3.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
4.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
5.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
6.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
7.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
8.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
9.The Exploration and Practice of Public Hospital Electronic Accounting File Management Based on Intelligent Financial System
Xiaochuan SHI ; Siming LI ; Shuran SUN ; Xuan ZHANG
Chinese Health Economics 2024;43(8):84-88,92
With the continuous development of information technology,smart financial systems has gradually become an important tool for financial management in public hospitals.As an important component of the smart financial system,electronic accounting record management is of great practical significance in adapting to the trend of"green and carbon free"economic development,improving the efficiency of financial management in public hospitals,and promoting high-quality development of hospitals.Henan Provincial People's Hospital is taken as an example(hereinafter referred to as the sample hospital)to deeply interpret national policies,explore the difficulties in electronic accounting file management,and combine with the specific situation of the hospital.Guided by the overall strategic goals of the hospital,starting from the top-level design integration,it creates a set of replicable and promotable electronic accounting voucher electronic reimbursement,entry,and archiving progress,so as to provide theoretical and practical experience for the transformation and upgrading of electronic record management in public hospitals,and provide a new template for the development and reform of economic management in public hospitals in China.
10.Efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in treatment of hepatocellular carcinoma
Changwang ZHANG ; Ninghan WU ; Cong WANG ; Zheng ZHENG ; Siming GAO ; Changpeng ZOU ; Sujing ZHANG ; Na LI
Journal of Clinical Hepatology 2024;40(6):1169-1174
Objective To investigate the efficacy and safety of cryoablation combined with Camrelizumab monoclonal antibody in the treatment of hepatocellular carcinoma(HCC).Methods A total of 103 HCC patients who were admitted to our hospital from June 2020 to June 2023 were enrolled and randomly divided into combined treatment group with 53 patients and control group with 50 patients.The patients in the control group received percutaneous argon-helium cryoablation,and those in the combined treatment group received percutaneous argon-helium cryoablation combined with Camrelizumab monoclonal antibody.The two groups were compared in terms of short-term response,changes in T lymphocyte subsets after treatment,changes in liver function and alpha-fetoprotein(AFP)after treatment,and progression-free survival and overall survival during follow-up.The t-test was used for comparison of normally distributed continuous data between groups,and the chi-square test was used for comparison of categorical data between groups.The Kaplan-Meier method was used to plot survival curves,and the log-rank test was used for comparison of survival time between the two groups.Results The combined treatment group had significantly higher overall response rate and disease control rate than the control group(χ2=4.156 and 4.348,P=0.042 and 0.037).After treatment,the combined treatment group had significant increases in the percentages of CD3+and CD4+T lymphocytes and CD4+/CD8+ratio(P<0.05)and a significant reduction in the percentage of CD8+T lymphocytes(P<0.05),while the control group had no significant changes in T lymphocyte subsets after treatment(P>0.05),and compared with the control group after treatment,the combined treatment group had significantly higher percentages of CD3+and CD4+T lymphocytes and CD4+/CD8+ratio(all P<0.05)and a significantly lower percentage of CD8+T lymphocytes(P<0.05).After treatment,both groups had significant reductions in the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and AFP(all P<0.05)and a significant increase in the level of albumin(Alb)(P>0.05),and compared with the control group after treatment,the combined treatment group had significantly lower levels of ALT,AST,and AFP(all P<0.05)and a significantly higher level of Alb(P<0.05).There were no significant differences in the incidence rates of grade Ⅲ—Ⅳ(moderate to severe)adverse reactions between the two groups(P>0.05).Compared with the control group,the combined treatment group had significantly better median progression-free survival(21.32 months vs 15.31 months,χ2=4.689,P=0.030)and median overall survival(28.36 months vs 20.75 months,χ2=5.030,P=0.025).Conclusion Argon-helium cryoablation combined with Camrelizumab monoclonal antibody can effectively improve short-term response,enhance immune function,and prolong survival time,with a favorable safety profile.

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