1.Preliminary analysis of combined romosozumab and denosumab versus teriparatide and denosumab on bone mineral density
Ming-Hung CHIANG ; Tian-Sin FAN ; Chia-Che LEE ; Tzu-Hao TSENG ; Hung-Kuan YEN ; Chih-Chien HUNG ; Yi-Chien LU ; Ning-Huei SIE ; Chen-Yu WANG ; Shau-Huai FU
Osteoporosis and Sarcopenia 2025;11(4):137-144
Objectives:
The effectiveness of combining romosozumab (ROMO) with denosumab (Dmab) remains uncertain.We compare the six-month effects of Dmab plus monthly ROMO versus Dmab plus daily teriparatide (TPTD) on bone mineral density (BMD) in treatment-naïve postmenopausal women with osteoporosis.
Methods:
This retrospective cohort study analyzed 26 treatment-naïve postmenopausal women with primary osteoporosis. Participants received either a monthly regimen of ROMO and Dmab (N = 14) or a daily regimen of TPTD plus Dmab (N = 12). BMD at the lumbar spine, total hip, and femoral neck was measured at baseline, 3 months, and 6 months by dual-energy X-ray absorptiometry. Serum levels of C-terminal telopeptide (CTX) and procollagen type I N-terminal propeptide (P1NP) were assessed at the same intervals.
Results:
Both regimens significantly improved lumbar spine BMD at 6 months (ROMO + Dmab: +9.75%; TPTD +Dmab: +7.42%). Improvements in total hip and femoral neck BMD were modest and similar between groups (~2%). Serum CTX and P1NP were significantly suppressed in both groups at 3 months, but P1NP suppression waned in the TPTD + Dmab group by 6 months. No statistically significant differences in BMD or marker changes were detected between the two regimens.
Conclusions
Both combination therapies effectively improve lumbar spine BMD over 6 months. The ROMO +Dmab regimen yielded numerically greater increases with fewer injections.
2.The Effect of Nurse Managers' Nursing Management Competence and Perceived Organizational Support on Job Stress in Small and Medium-Sized Hospitals
Gaeun KIM ; Sie-Eun KIM ; Suk-Jung HAN
Korean Journal of Occupational Health Nursing 2025;34(3):105-116
Purpose:
This study aimed to examine the effects of nursing management competency and organizational support perception on the job stress of nurse managers in small and medium-sized hospitals.
Methods:
A total of 385 nurse managers from hospitals in Seoul, Korea, were surveyed in 2023. Data analysis was performed using SPSS 25.0, and included descriptive statistics, t-tests, one-way ANOVA, Pearson’s correlation coefficients, and hierarchical multiple regression analysis.
Results:
Significant predictors of job stress included hospital dissatisfaction (β=.23, p=.001), desire to change jobs (β=-.14, p<.001), nursing management competency (β=.08, p=.047), and organizational support perception (β=-.64, p<.001), The regression model was shown to be statistically significant (F=57.22, p<.001), explaining 56.9% of the variance in job stress.
Conclusion
Nursing management competency and organizational support perception were significant factors affecting job stress. Enhancing these factors through targeted training and organizational strategies may help reduce stress among nurse managers in small and medium-sized hospital settings.
3.Factors Affecting the Resilience of Hospital Nurses: Hope, Self-efficacy, Stress Coping Ability, and Communication Ability
Korean Journal of Occupational Health Nursing 2024;33(2):64-73
Purpose:
This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses.
Methods:
The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression.
Results:
The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience.
Conclusion
In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.
4.Factors Affecting the Resilience of Hospital Nurses: Hope, Self-efficacy, Stress Coping Ability, and Communication Ability
Korean Journal of Occupational Health Nursing 2024;33(2):64-73
Purpose:
This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses.
Methods:
The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression.
Results:
The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience.
Conclusion
In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.
5.Factors Affecting the Resilience of Hospital Nurses: Hope, Self-efficacy, Stress Coping Ability, and Communication Ability
Korean Journal of Occupational Health Nursing 2024;33(2):64-73
Purpose:
This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses.
Methods:
The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression.
Results:
The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience.
Conclusion
In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.
6.Factors Affecting the Resilience of Hospital Nurses: Hope, Self-efficacy, Stress Coping Ability, and Communication Ability
Korean Journal of Occupational Health Nursing 2024;33(2):64-73
Purpose:
This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses.
Methods:
The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression.
Results:
The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience.
Conclusion
In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.
7.Factors Affecting the Resilience of Hospital Nurses: Hope, Self-efficacy, Stress Coping Ability, and Communication Ability
Korean Journal of Occupational Health Nursing 2024;33(2):64-73
Purpose:
This study was conducted to determine the influence of hope, self-efficacy, stress coping ability, and communication ability on the resilience of hospital nurses.
Methods:
The sample of this study comprised 201 nurses working in the general hospital located in Seoul, Korea for the year of 2024. Data were analyzed using SPSS 25.0, and the analyses included descriptive statistics, t-test, Pearson's ANOVA, and multiple regression.
Results:
The factors associated with the level of nurses' resilience were hope (β=.41, p<.001), communication (β=.33, p<.001) and stress coping ability (β=.15, p=.005). These factors had an explanatory power of 61.5% (F=32.92, p<.001) in resilience.
Conclusion
In order to improve nurses' resilience, various trainings and programs need to be developed to enhance nurses' hope, stress coping ability and communication.
8.Morphology of Mandibular Condyle in The Population of Sarawak: A Retrospective Cross-sectional Study Using Digital Panoramic Radiograph
Tan Yy Jean ; Lim Woei Tatt ; Lee Sie Wei ; Shim Chen Kiong ; Mohamad Adam Bujang
Malaysian Journal of Medicine and Health Sciences 2023;19(No.4):258-264
Introduction: The morphology of the condyles changes naturally with age, gender, face type, occlusal force, functional load, malocclusion type, and the right and left sides. Although condylar shape and size differ throughout
populations, there have been few investigations on condylar morphology, particularly in the Malaysian population.
Methods: This retrospective, observational, cross-sectional survey was conducted at the Oral and Maxillofacial Surgery Clinic of Sarawak General Hospital from September 2021 to March 2022, involving radiographic assessment
of condylar morphology from 893 panoramic radiographs. Age, gender, ethnicity and dentition status using Eichner
index were extracted from the data. Descriptive statistics were used. Pearson’s chi-square test was used to determine
the association between the independent variables (age, gender, ethnicity and dentition status) and the shape of the
mandibular condyle. A p-value of < 0.05 was considered statistically significant. Results: Only 450 panoramic radiographs were included in this study. The condyles were outlined and grouped into four categories, namely pointed
(40.2%), round (32.8), angled (18.8), and flat (8.2%). Condylar morphology was found to be significantly associated
with gender (p<0.005) and insignificant with other independent variables. Conclusion: The findings suggest that the
most prevalent condylar morphology among the Sarawak population is the pointed shape, in contrast with other
previous studies that reported the round shape condylar morphology as the majority shape.
9.Influence of Postconceptional Age on the Renal Biomarkers in Very-Low-Birth-Weight Infants
Ro Sie LEE ; So Young SHIN ; Won Ho JUNG ; Jae Hyun PARK
Neonatal Medicine 2021;28(2):65-71
Purpose:
We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in very-low-birth-weight (VLBW) infants.
Methods:
Repeatedly measured samples for each infant were divided into four groups according to postnatal age: at birth (stage I), 3 to 7 days postnatally (stage II), 8 to 28 days postnatally (stage III), and >28 days postnatally (stage IV). The association between renal biomarkers and postconceptional age was assessed using Pearson’s correlation coefficient, and the mean values of renal biomarkers in the four stages were compared using repeated-measures analysis of variance.
Results:
For samples measured at birth, serum CysC (r=–0.358, P=0.032) and urinary NGAL/Cr ratio (r=–0.522, P=0.001) were negatively correlated with gestational age, whereas serum Cr (r=0.148, P=0.390) was not. In addition, for all samples measured, serum CysC (r=–0.209, P=0.012), urinary NGAL/Cr ratio (r=–0.536, P<0.001), and serum Cr (r=–0.311, P<0.001) were negatively correlated with postconceptional age. Compared with the mean values of the postnatal age-specific stages, serum CysC showed no significant differences in any of the four stages. However, the urinary NGAL/Cr ratio in stage IV was significantly different from those in stages I to III.
Conclusion
Although urinary NGAL/Cr ratio and serum CysC were negatively correlated with postconceptional age considering renal development, serum CysC showed no significant differences in any of the four postnatal age-specific stages. Urinary NGAL/Cr ratio at >28 days postnatally seems to be more affected by postconceptional age than serum CysC in VLBW infants.
10.Influence of Postconceptional Age on the Renal Biomarkers in Very-Low-Birth-Weight Infants
Ro Sie LEE ; So Young SHIN ; Won Ho JUNG ; Jae Hyun PARK
Neonatal Medicine 2021;28(2):65-71
Purpose:
We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in very-low-birth-weight (VLBW) infants.
Methods:
Repeatedly measured samples for each infant were divided into four groups according to postnatal age: at birth (stage I), 3 to 7 days postnatally (stage II), 8 to 28 days postnatally (stage III), and >28 days postnatally (stage IV). The association between renal biomarkers and postconceptional age was assessed using Pearson’s correlation coefficient, and the mean values of renal biomarkers in the four stages were compared using repeated-measures analysis of variance.
Results:
For samples measured at birth, serum CysC (r=–0.358, P=0.032) and urinary NGAL/Cr ratio (r=–0.522, P=0.001) were negatively correlated with gestational age, whereas serum Cr (r=0.148, P=0.390) was not. In addition, for all samples measured, serum CysC (r=–0.209, P=0.012), urinary NGAL/Cr ratio (r=–0.536, P<0.001), and serum Cr (r=–0.311, P<0.001) were negatively correlated with postconceptional age. Compared with the mean values of the postnatal age-specific stages, serum CysC showed no significant differences in any of the four stages. However, the urinary NGAL/Cr ratio in stage IV was significantly different from those in stages I to III.
Conclusion
Although urinary NGAL/Cr ratio and serum CysC were negatively correlated with postconceptional age considering renal development, serum CysC showed no significant differences in any of the four postnatal age-specific stages. Urinary NGAL/Cr ratio at >28 days postnatally seems to be more affected by postconceptional age than serum CysC in VLBW infants.


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