Objective To systematically analyze the characteristics of functioning and vocational competency of college students with disabilities and explore effective career development pathways and methods.Methods This study systematically examined the functional characteristics and occupational competency structure of college students with disabilities,and proposed pathways to enhance their career development,using Internation-al Classification of Functioning,Disability and Health(ICF),rehabilitation competency framework(RCF),and achievement motivation theory.Results The study analyzed the functional performance of college students with disabilities across dimensions such as body functions and structures,activities and participation,and environmental factors,as well as their impact on occupational activities,using the Core Sets for Vocational Rehabilitation and the WHO Disability Assessment Schedule 2.0(WHODAS 2.0).The study outlined the occupational competency framework for these students and proposed three synergistic pathways to enhance their career development,including empowerment,functional compensation,and inclusive environmental support,based on RCF and achievement motivation theory.Early in-tervention,professional career services and multi-stakeholder collaboration mechanisms were recommended to provide lifelong,personalized career counseling,guidance and support based on precise occupational needs and competency assessments.Conclusion The career development of college students with disabilities is influenced by multiple factors,including indi-vidual functional status,occupational competency and environmental conditions.Implementing strategies such as empowerment,functional compensation,and inclusive environmental support could safeguard their right to em-ployment in an inclusive workplace,effectively improving their employment quality and sustainable career devel-opment capabilities.

Objective To systematically analyze the characteristics of functioning and vocational competency of college students with disabilities and explore effective career development pathways and methods.Methods This study systematically examined the functional characteristics and occupational competency structure of college students with disabilities,and proposed pathways to enhance their career development,using Internation-al Classification of Functioning,Disability and Health(ICF),rehabilitation competency framework(RCF),and achievement motivation theory.Results The study analyzed the functional performance of college students with disabilities across dimensions such as body functions and structures,activities and participation,and environmental factors,as well as their impact on occupational activities,using the Core Sets for Vocational Rehabilitation and the WHO Disability Assessment Schedule 2.0(WHODAS 2.0).The study outlined the occupational competency framework for these students and proposed three synergistic pathways to enhance their career development,including empowerment,functional compensation,and inclusive environmental support,based on RCF and achievement motivation theory.Early in-tervention,professional career services and multi-stakeholder collaboration mechanisms were recommended to provide lifelong,personalized career counseling,guidance and support based on precise occupational needs and competency assessments.Conclusion The career development of college students with disabilities is influenced by multiple factors,including indi-vidual functional status,occupational competency and environmental conditions.Implementing strategies such as empowerment,functional compensation,and inclusive environmental support could safeguard their right to em-ployment in an inclusive workplace,effectively improving their employment quality and sustainable career devel-opment capabilities.

Recent innovations in nanomaterials inspire abundant novel tumor-targeting CRISPR-based gene therapies. However, the therapeutic efficiency of traditional targeted nanotherapeutic strategies is limited by that the biomarkers vary in a spatiotemporal-dependent manner with tumor progression. Here, we propose a self-amplifying logic-gated gene editing strategy for gene/H₂O₂-mediated/starvation multimodal cancer therapy. In this approach, a hypoxia-degradable covalent-organic framework (COF) is synthesized to coat a-ZIF-8 in which glucose oxidase (GOx) and CRISPR system are packaged. To intensify intracellular redox dyshomeostasis, DNAzymes which can cleave catalase mRNA are loaded as well. When the nanosystem gets into the tumor, the weakly acidic and hypoxic microenvironment degrades the ZIF-8@COF to activate GOx, which amplifies intracellular H⁺ and hypoxia, accelerating the nanocarrier degradation to guarantee available CRISPR plasmid and GOx release in target cells. These tandem reactions deplete glucose and oxygen, leading to logic-gated-triggered gene editing as well as synergistic gene/H₂O₂-mediated/starvation therapy. Overall, this approach highlights the biocomputing-based CRISPR delivery and underscores the great potential of precise cancer therapy.

Objective To investigate oxygen nebulizer usage among inpatients in an upper first‐class hospital so that this de‐vice can be used by medical personnel and patients properly .Methods Totally 409 patients were investigated about the usage of the device from May 12th to 30th 2014 ,whose outcomes were analyzed by Excel2007 software .Results The total liquid volume of in‐halation on prescription was much larger than the favorable one ,ranging from 4 to 6 mL .And the Oxygen flow ,ranging from 2 .5 to 3 .5 L/min ,was much lower than the normal flow (ranging from 6 to 8 L/min) .In addition ,all patients failed to breathe normally with occasional deep breaths and failed to gargle timely after corticosteroid inhalation .Only 3% patients cleaned their faces after corticosteroid inhalation ,43 .5% patients sit in an upright position ,44 .0% patients kept the nebulizer vertical during treatment .The accuracy rates of mouthpiece position ,the right time to stop nebulizer therapy ,rinsing the nebulizer with sterile or distilled water and allowing to air dry were 95 .1% ,99 .2% ,and 99 .3% ,respectively .Conclusion There are many common patient use nebulizer incorrectlly in the upper first‐class hospital ,and education and guidance by medical personnel should be strengthened .

Purpose　The aim is to study the effects of solubl e chit osan on antitumor factors and NK cell activity in rats.Methods　The level of NO、TNF produced by peritoneal macrophages,IFN-γ production and NK ce ll activity of spleen was detected,after different concentrations of chitosan we re injected into the sarcoma 180 rats peritoneally.Results　Th e cont ents of NO、TNF、IFN-γ and NK cell activity in sacroma 180 rats were significa ntly higher in the chitosan groups than those in the control group (P＜0.01) .Conclusion　Chitosan could impove the immune function in rats .