Multimodal biometric identification technology,which combines multiple biometric methods,is being increasingly used in forensic science due to its advantages such as difficulty of forgery and great accuracy.However,the current identification mainly relies on unimodal biometrics including facial recognition,hand recognition,iris recognition,gait recognition,and voice recognition.Thus,to a large extent,the accuracy of identification depends on the quality of the unimodal data,which faces multiple challenges.In contrast,multimodal biometrics has more obvious advantages in the field of identification,which can not only effectively resist attacks,but also enrich the feature representation with complementary information from multimodal sources,mitigate the impact of environment on the identification performance,and enhance the robustness of the system.To this end,this paper combs through the relevant work in this field,and comprehensively reviews the current research status and development trend of biometric identification technology.First,based on bibliometrics,the paper combs through the relevant research results in the past ten years,analyzes,summarizes,and discusses the commonly used deep learning models in this field,respectively,from unimodal recognition to multi-modal fusion recognition.Then the paper discusses the future development direction of the multimodal biometric identification field in the light of the practical needs of court science and provides reference for identification research.

Objective To explore the efficiency of operating room(OR)and its influencing factors from a phenomeno-logical perspective,proposing corresponding improvement strategies.Methods A phenomenological method was adopted,invol-ving in-depth interviews with 13 surgical team members from a tertiary Traditional Chinese Medicine(TCM)orthopedic hospital in Henan Province,to collect and analyze their multifaceted understanding of OR efficiency.Results The study demonstrated eight interpretative ways of efficiency among team members.The overall framework was largely organization-oriented,with addi-tional human-centered considerations regarding the factors influencing efficiency.Conclusion A unified understanding is crucial for improving both efficiency and quality.This study suggests strategies to optimize OR processes through lean management and human-centered team development to enhance operating room efficiency.Additionally,it highlights the need for future research to incorporate more patient views.

Objective To evaluate the clinical efficacy and safety of Wuwei Wentong Chubi Capsules in patients with rheumatoid arthritis of cold and dampness obstruction syndrome under real world based on clinical medical record information system.Methods Medical history,symptoms and medication information of hospitalized patients with rheumatoid arthritis of cold and dampness obstruction syndrome in the Department of Rheumatology,First Affiliated Hospital of Anhui University of Chinese Medicine were collected from January 2020 to March 2024.According to whether to use Wuwei Wentong Chubi Capsules,patients were divided into treatment group(304 cases)and control group(378 cases).A database was established after improving the information and indicators of two groups of patients.TCM syndrome scores,disease activity scores and laboratory indicators of both groups were compared.Results Compared with before treatment,TCM syndrome score(severe joint pain,morning stiffness,swelling,worsening pain when encountering cold,poor joint flexion and extension,eating less and eating more,lack of breath and lazy speech,weak mouth and thirst,heavy head and body fatigue,loose stools and fatigue)in the treatment group significantly decreased after treatment(P<0.05),the disease activity score,erythrocyte sedimentation rate(ESR),high-sensitivity C-reactive protein(hs-CRP),rheumatoid factor(RF),complement(C3,C4),immunoglobulin(Ig)G,IgM,anti cyclic citrullinated peptide antibody(anti CCP antibody),thyroid stimulating hormone(TSH),anti thyroglobulin antibody(TGAb),and anti thyroid peroxidase antibody(TPOAb)were significantly reduced(P<0.05),and free triiodothyronine(FT3)and free tetraiodothyronine(FT4)increased(P<0.05);after treatment,TCM syndrome score(severe joint pain,morning stiffness,swelling,fatigue and weakness)in the control group significantly decreased,and the disease activity score,ESR,hs-CRP,RF,the levels of anti CCP antibodies,TGAb,and TPOAb were significantly reduced(P<0.05);compared with the control group after treatment,TCM syndrome scores in the treatment group showed more significant improvement(P<0.05)in terms of joint morning stiffness,swelling,poor flexion and extension,exacerbation of cold exposure,eating less and eating more,lack of breath and speech,weak and dry mouth,heavy head and body fatigue and fatigue.Disease activity score,ESR,hs-CRP,RF,the levels of anti CCP antibodies,C3,IgG,TSH and TPOAb decreased more significantly,while FT3 and FT4 increased more significantly(P<0.05);both groups had normal blood routine and liver and kidney function before and after treatment,with no significant difference(P>0.05).According to the analysis of association rules,after using Wuwei Wentong Chubi Capsules,there was a significant improvement in ESR,hs-CRP,RF,C3,IgG,TSH,FT4 and TPOAb indicators,with a degree of improvement greater than 1,indicating a strong association.Conclusion Wuwei Wentong Chubi Capsules can effectively improve the cold and dampness obstruction syndrome and spleen deficiency dampness excess syndrome in patients with rheumatoid arthritis cold dampness obstruction syndrome,reduce disease activity index and immune inflammatory indicators,and have a certain regulatory effect on thyroid immune dysfunction and the clinical application has good safety.

Multimodal biometric identification technology,which combines multiple biometric methods,is being increasingly used in forensic science due to its advantages such as difficulty of forgery and great accuracy.However,the current identification mainly relies on unimodal biometrics including facial recognition,hand recognition,iris recognition,gait recognition,and voice recognition.Thus,to a large extent,the accuracy of identification depends on the quality of the unimodal data,which faces multiple challenges.In contrast,multimodal biometrics has more obvious advantages in the field of identification,which can not only effectively resist attacks,but also enrich the feature representation with complementary information from multimodal sources,mitigate the impact of environment on the identification performance,and enhance the robustness of the system.To this end,this paper combs through the relevant work in this field,and comprehensively reviews the current research status and development trend of biometric identification technology.First,based on bibliometrics,the paper combs through the relevant research results in the past ten years,analyzes,summarizes,and discusses the commonly used deep learning models in this field,respectively,from unimodal recognition to multi-modal fusion recognition.Then the paper discusses the future development direction of the multimodal biometric identification field in the light of the practical needs of court science and provides reference for identification research.

Objective To explore the efficiency of operating room(OR)and its influencing factors from a phenomeno-logical perspective,proposing corresponding improvement strategies.Methods A phenomenological method was adopted,invol-ving in-depth interviews with 13 surgical team members from a tertiary Traditional Chinese Medicine(TCM)orthopedic hospital in Henan Province,to collect and analyze their multifaceted understanding of OR efficiency.Results The study demonstrated eight interpretative ways of efficiency among team members.The overall framework was largely organization-oriented,with addi-tional human-centered considerations regarding the factors influencing efficiency.Conclusion A unified understanding is crucial for improving both efficiency and quality.This study suggests strategies to optimize OR processes through lean management and human-centered team development to enhance operating room efficiency.Additionally,it highlights the need for future research to incorporate more patient views.

Objective To evaluate the clinical efficacy and safety of Wuwei Wentong Chubi Capsules in patients with rheumatoid arthritis of cold and dampness obstruction syndrome under real world based on clinical medical record information system.Methods Medical history,symptoms and medication information of hospitalized patients with rheumatoid arthritis of cold and dampness obstruction syndrome in the Department of Rheumatology,First Affiliated Hospital of Anhui University of Chinese Medicine were collected from January 2020 to March 2024.According to whether to use Wuwei Wentong Chubi Capsules,patients were divided into treatment group(304 cases)and control group(378 cases).A database was established after improving the information and indicators of two groups of patients.TCM syndrome scores,disease activity scores and laboratory indicators of both groups were compared.Results Compared with before treatment,TCM syndrome score(severe joint pain,morning stiffness,swelling,worsening pain when encountering cold,poor joint flexion and extension,eating less and eating more,lack of breath and lazy speech,weak mouth and thirst,heavy head and body fatigue,loose stools and fatigue)in the treatment group significantly decreased after treatment(P<0.05),the disease activity score,erythrocyte sedimentation rate(ESR),high-sensitivity C-reactive protein(hs-CRP),rheumatoid factor(RF),complement(C3,C4),immunoglobulin(Ig)G,IgM,anti cyclic citrullinated peptide antibody(anti CCP antibody),thyroid stimulating hormone(TSH),anti thyroglobulin antibody(TGAb),and anti thyroid peroxidase antibody(TPOAb)were significantly reduced(P<0.05),and free triiodothyronine(FT3)and free tetraiodothyronine(FT4)increased(P<0.05);after treatment,TCM syndrome score(severe joint pain,morning stiffness,swelling,fatigue and weakness)in the control group significantly decreased,and the disease activity score,ESR,hs-CRP,RF,the levels of anti CCP antibodies,TGAb,and TPOAb were significantly reduced(P<0.05);compared with the control group after treatment,TCM syndrome scores in the treatment group showed more significant improvement(P<0.05)in terms of joint morning stiffness,swelling,poor flexion and extension,exacerbation of cold exposure,eating less and eating more,lack of breath and speech,weak and dry mouth,heavy head and body fatigue and fatigue.Disease activity score,ESR,hs-CRP,RF,the levels of anti CCP antibodies,C3,IgG,TSH and TPOAb decreased more significantly,while FT3 and FT4 increased more significantly(P<0.05);both groups had normal blood routine and liver and kidney function before and after treatment,with no significant difference(P>0.05).According to the analysis of association rules,after using Wuwei Wentong Chubi Capsules,there was a significant improvement in ESR,hs-CRP,RF,C3,IgG,TSH,FT4 and TPOAb indicators,with a degree of improvement greater than 1,indicating a strong association.Conclusion Wuwei Wentong Chubi Capsules can effectively improve the cold and dampness obstruction syndrome and spleen deficiency dampness excess syndrome in patients with rheumatoid arthritis cold dampness obstruction syndrome,reduce disease activity index and immune inflammatory indicators,and have a certain regulatory effect on thyroid immune dysfunction and the clinical application has good safety.

Forensic injury analysis is of great significance in the field of forensic medicine,but the complexity of injury formation process and individual differences make it highly professional.The finite element method(FEM),with its wide applicability,controllable accuracy and efficient computing power,combined with visualization,has shown great application potential in the field of forensic science.Through literature analysis,this paper introduces the basic principles of FEM and discusses its application in analysis of injuries caused by traffic accidents,shooting,tool injury and fall from height.By analyzing the simulation parameters,simulation results and research focus of each application scenario and collision site,this study evaluates the feasibility and limitations of FEM in forensic injury analysis,thereby providing reference and technical approaches for forensic injury analysis.

Forensic injury analysis is of great significance in the field of forensic medicine,but the complexity of injury formation process and individual differences make it highly professional.The finite element method(FEM),with its wide applicability,controllable accuracy and efficient computing power,combined with visualization,has shown great application potential in the field of forensic science.Through literature analysis,this paper introduces the basic principles of FEM and discusses its application in analysis of injuries caused by traffic accidents,shooting,tool injury and fall from height.By analyzing the simulation parameters,simulation results and research focus of each application scenario and collision site,this study evaluates the feasibility and limitations of FEM in forensic injury analysis,thereby providing reference and technical approaches for forensic injury analysis.

Objective:To analyze the clinical and epidemiological characteristics of adult carotid body tumors (CBTs) in Northwest China to provide references for early diagnosis and treatment of CBTs.Methods:A multicenter, retrospective, non-intervention epidemiological investigation was conducted on adult CBTs patients who were hospitalized from January 1, 2011 to June 30, 2023 in 7 Class A tertiary hospitals in Northwest China (Departments of Neurosurgery, First Affiliated Hospital of Air Force Medical University, Second Affiliated Hospital of Lanzhou University, People's Hospital of Gansu Province, 940 th Hospital of PLA Joint Logistic Support Force, People's Hospital of Qinghai Province, General Hospital of Ningxia Medical University, People's Hospital of Ningxia Hui Autonomous Region). Medical records were collected in these patients, and they were divided into 2 groups according to their average altitude residence: high altitude group (≥1 500 m) and low altitude group (<1 500 m); meanwhile, these patients were divided into Shamblin type I, type II and type III groups according to Shamblin classification criteria; differences in general data and clinical features among patients from different altitude groups or Shamblin subgroups were compared. Independent influencing factors for Shamblin type III CBTs were analyzed by multivariate ordered Logistic regression. Results:(1) A total of 359 patients were enrolled in the study, including 276 females and 83 males, aged (48.80±12.07) years; 211 patients were into the high altitude group and 148 into the low altitude group; 165 patients were into Shamblin type I group, 146 into Shamblin type II group, and 48 into Shamblin type III group. (2) Compared with those in the low altitude group, patients in the high altitude group had higher proportion of females, older age, lower proportion of Han nationality, higher proportion of Shamblin type I, smaller tumor volume, lower platelet count, higher red blood cell count, hematocrit, hemoglobin level, platelet distribution width and mean platelet volume, and higher large platelet percentage, with significant differences ( P<0.05). (3) Compared with those in the Shamblin type I group, patients in the Shamblin type III group had younger age, lower resident altitude, larger tumor volume, longer time interval from onset to diagnosis, higher proportion of unintentional tumor discovery, larger volume of intraoperative blood loss, lower hemoglobin level, hematocrit, mean erythrocyte volume, and mean hemoglobin concentration, decreased erythrocyte distribution width variable coefficient, and increased platelet count, with significant differences ( P<0.05). Compared with those in the Shamblin type II group, patients in Shamblin type III group had younger age, larger tumor volume, longer time interval from onset to diagnosis, larger volume of intraoperative blood loss, lower hemoglobin, hematocrit and mean erythrocyte volume, higher erythrocyte distribution width variable coefficient and platelet count, with significant differences ( P<0.05). (4) Age ( OR=0.960, 95% CI: 0.942-0.977, P<0.001), residence altitude ( OR=0.992, 95% CI: 0.990-0.999, P=0.020) and time interval from onset to diagnosis ( OR=1.009, 95% CI: 1.005-1.014, P<0.001) were independent influencing factors for Shamblin type III CBTs. Conclusions:More females than males are noted in patients with adult CBTs in Northwest China, and more CBTs patients live at high altitude, with Shamblin type I enjoying the highest proportion. More female and old patients lived at high altitude is noted than those lived at low altitude; patients with Shamblin type III have the youngest age, lowest altitude, and longest time interval from onset to diagnosis. CBTs patients with young age, low residence altitude, and long time interval from onset to diagnosis are more likely to develop Shamblin type III.

Acute hypobaric hypoxic brain damage is a potentially fatal high-altitude sickness. Autophagy plays a critical role in ischemic brain injury, but its role in hypobaric hypoxia (HH) remains unknown. Here we used an HH chamber to demonstrate that acute HH exposure impairs autophagic activity in both the early and late stages of the mouse brain, and is partially responsible for HH-induced oxidative stress, neuronal loss, and brain damage. The autophagic agonist rapamycin only promotes the initiation of autophagy. By proteome analysis, a screen showed that protein dynamin2 (DNM2) potentially regulates autophagic flux. Overexpression of DNM2 significantly increased the formation of autolysosomes, thus maintaining autophagic flux in combination with rapamycin. Furthermore, the enhancement of autophagic activity attenuated oxidative stress and neurological deficits after HH exposure. These results contribute to evidence supporting the conclusion that DNM2-mediated autophagic flux represents a new therapeutic target in HH-induced brain damage.
Mice ; Animals ; Hypoxia ; Oxidative Stress ; Autophagy ; Cognition ; Sirolimus/therapeutic use*