It is proposed that both "skin interior-membrane exterior" （the region between the skin and membranes） and "membrane-source" are objective parts of human body. Based on relevant ancient texts， interpretations by physicians， and clinical characteristics of diseases， we analysed the relationship between skin interior-membrane exterior and membrane-source， and proposed that skin interior-membrane exterior is essentially equivalent to membrane-source， with skin interior-membrane exterior offering a clearer expression of the meaning. The medicinal practices and prescriptions recorded in materia medica and classical formulas provide evidence to support that skin interior-membrane exterior is same as membrane-source. Based on the researches on their relationship， the formula groups for the treatment of membrane-source diseases developed， potentially expanding the clinical applications of membrane-source formulas and offering new approaches to the diagnosis and treatment of complex diseases in clinic.

Yin-yang, visceral manifestation, and ti-yong theories are the core theories of traditional Chinese medicine (TCM) and play a crucial role in its formation and development. With the continuous evolution of Chinese philosophy, TCM philosophy and theories have undergone significant influence, resulting in differing interpretations of the visceral manifestation of liver and mingmen across various historical periods by different medical practitioners. This paper focuses on the different understandings of the position of liver and mingmen, combining relevant philosophical images and TCM anatomical illustrations to deeply explore ancient medical theorists′ concepts regarding the four spatial directions of left, right, up, and down. The research reveals that ancient medical theorists′ conceptualization of spatial theory transitioned from an initial circular motion to a vertical movement, with the focus shifting from the upper part to the lower part. The primary reasons for these differences and changes could be explained by the varying emphasis on the ti-yong theory and differing focal points within the yin-yang theory. This study systematically examines the evolution of visceral manifestation theories related to liver and mingmen, highlights the shifts in physicians′ perspectives on spatial theory, and analyzes the influence of the ti-yong theory and yin-yang theory on these changes. The findings aim to provide a theoretical guide for advancing research and clinical application of spatial theory in TCM, thereby fostering the integration of TCM philosophy with medical theory.

It is proposed that the essence of the half-interior half-exterior theory of the membrane-source lies in the concept of the interstitial space being half-interior half-exterior. Through analysis of classical medical texts and commentaries by renowned physicians， the relationship between the membrane-source interstitial layer and the Governor Vessel （督脉） is explored. It is argued that the Governor Vessel traverses beyond the membrane-source interstitial half-interior half-exterior layer， and that this layer is related to， but distinct from， the shaoyang channel's half-interior half-exterior characteristic. By examining both historical and modern clinical approaches， further evidence is provided to support the view that the Governor Vessel passes outside this interstitial layer. Based on this relationship， treatment principles and prescriptions for Governor Vessel-related disorders are referenced to formulate strategies for membrane-source disorders， offering new perspectives for addressing complex and difficult clinical conditions.

To clarify the reasons for the phenomenon of producing different viewpoints in the theory of Huangdi Neijing and how to understand and apply these different viewpoints correctly. This study explores the founding basis of the characteristics of "viewpoint integration" in the theory system of Huangdi Neijing and explains the theoretical significance and clinical value of "viewpoint integration" from the perspective of the core concept of Huangdi Neijing. In conclusion, when grasping the characteristics of "viewpoint integration" in Huangdi Neijing, thinking about, recognizing, analyzing, and solving problems is the main line and the core. Understanding different points of view should be extensive and in-depth. Do not use one viewpoint to understand all viewpoints, do not use one viewpoint to explain another viewpoint, and do not mechanically mix two viewpoints. At the same time, it is necessary to clarify the construction process of different viewpoints and to learn to grasp these viewpoints from different angles. Studying the characteristics of "viewpoint integration" in Huangdi Neijing can not only better understand the theoretical content of Huangdi Neijing, but can also help open up ideas for the diagnosis and treatment of diseases, develop and innovate the theory of traditional Chinese medicine, and improve clinical efficacy.

Consumptive thirst is widely discussed in Huangdi Neijing and it is classified as a"strange disease"in Suwen·Strange Diseases Treatise,which reflects the intractable nature of consumptive thirst.This paper explores and analyzes consumptive thirst based on the core concept in Huangdi Neijing.First,this paper approaches the subject through the use of image thinking method from Huangdi Neijing,recognizing that consumptive thirst can lead to changes in the internal climate of the human body.Then,guided by the theories of essence and qi,yin and yang,and the five elements in Huangdi Neijing,it deconstructs and analyzes the causes of these changes and the laws of qi transformation.It points out that the changing climate of consumptive thirst is characterized by"heat symptoms".The main cause of"heat symptoms"is spleen deficiency and excessive dampness,and its qi transformation law is the heat transformation of Shaoyin.The intractable nature of consumptive thirst is mainly reflected in the uncontrolled"heat symptoms"caused by the imbalance of the five elements.Based on the understanding of the heat symptoms of consumptive thirst,this paper proposes a treatment strategy for preventing the disease by resolving dampness and regulating the spleen,harmonizing kidney qi to prevent progression,and balancing yin and yang to treat chronic and recalcitrant conditions.The aim is to provide a reference for optimizing the treatment of consumptive thirst.

From the perspectives of traditional Chinese medicine （TCM） information knowledge base and assisted decision-making knowledge base， the construction status， quality evaluation status and existing problems of current TCM knowledge bases have been sorted out. And based on the quality evaluation strategies and dimensions of know-ledge bases in other disciplines， the evaluation indexes for TCM knowledge base is discussed， and the evaluation framework is initially formed， providing ideas for the improvement of the TCM knowledge base evaluation system. In terms of the evaluation indexes， there are basic evaluation dimensions which include data sources， data collection， and data application. The specific evaluation dimension of the information-based knowledge base is data quality， while that of the assisted decision-making knowledge base is data matching. Except for the data application dimension which counts the valid data items in the database for calculation， other indexes are scored based on the qualitative evaluation of "yes"， "no" or "unknown". The basic evaluation score and the specific evaluation score are added to obtain the total score. The knowledge base is graded according to the score， and the results are presented in the form of grade plus number.

Objective:To study the medication rules of treating cervical spondylosis by National TCM master Liu Bailing based on data mining and network pharmacology, and explore the potential action mechanism of its core compounds.Methods:By collecting the prescriptions of National TCM master Liu Bailing treating cervical spondylosis in the past 8 years, this paper analyses the frequency, nature, flavor, meridian, hierarchical clustering and association rules of those prescriptions by RStudio to obtain the core prescription. Then, the effective components of the core prescription were collected by using TCMSP, and the network of "medicine-component-target" was constructed by using Cytoscape 3.8.0; by searching for databases like GEO, DisGeNET, TTD HPO and Genecards were retrieved to obtain the target data set of cervical spondylosis; by using STRING 11.0 platform to construct protein interaction network; by using DAVID platform to cary out gene ontology (GO) and KEGG pathway enrichment analysis; by using Auto Dock software for molecular docking.Results:In the 844 prescriptions, there are 199 Chinese medicines and the properties are mainly warm, plain and cold; the flavors were mainly sweet, pungent and bitter; mainly belong to the liver, spleen, and kidney meridians. The Association Rule shows that the core compound is made up of Salvia miltiorrhiza, Gastrodia elata, Rhizoma corydalis, Alisma rhizoma, centipede, Astragalus membranaceus and Rhizome of Pueraria. Besides, 140 effective constituents and 247 targets of the core prescription were screened, and the main constituents were quercetin, kamanol, luteolin, tanshinone ⅡA, β-sitosterol, etc. 13 core targets among the core prescription treating cervical spondylosis were obtained, which were enriched into 30 pathways including toll-like receptor signaling pathway, TNF signaling pathway and HIF-1 signaling pathway. Conclusion:National TCM master Liu Bailing treatment of cervical spondylosis mainly focuses on expelling wind and relieving pain, dredging meridians and soothing tendons, and the mechanism of action of the core prescription may focus on inhibiting inflammatory response and relieving oxidative stress, providing guidance and reference for the clinical treatment of cervical spondylosis.

This article compares and analyzes the content and theoretical structure of the concept of pathogenesis from the national textbooks of Basic Theory of Chinese Medicine and Diagnostics in Chinese Medicine from the first to the ninth version.The authors consider the mechanism as the main content of pathogenesis concept in contemporary Chinese medicine.During the construction of this concept,the concept of pathology has a profound influence,wh ich differs a lot from the emphasis on key in ancient pathogenesis content,mainly reflected in clinical diagnosis and treatment ideas transferring from dealing with key issues to dealing with abstract concept.This change is associated with the impact of western medicine on modern Chinese medicine,emphasizing the mechanism and so on,so that the ancient Xiang (象) concept is marginalized.

“Mechanical memory” approach was commonly used in the knowledge learning of traditional Chinese medicine, which makes students often feel that the knowledge is too abstract, and this method is thus ineffective. “Qihuang the way” using Unity 3D game development platform inte-grates the elements of medical knowledge of the Chinese medical history, and combines TCM theoretical knowledge learning with serious games , which can help invoke students' enthusiasm and improve learning efficiency in an entertaining way.

From the human cognition procedure,after initially explores the formation and essence of Traditional Chinese Medicine(TCM) related concepts,the author believes that the TCM related concepts are based on the phenomena(including the outside appearance of human body) in the natural world which can be felt directly by people’s sense organs,with the essence that is the re? ection of macro symptoms and physical signs,and the relative natural objective phenomena in people’s consciousness.In traditional Chinese medicine,there are not only the concepts formed by the things which can be felt directly by people’s senseorgans,but also those which are formed independent on the cognition by sense organs directly,and must be thought further.Either is not utterly visionary,the formation all based on the objective phenomena.If you grasp the phenomena,these concepts are not unacceptable and the TCM related research will stand on the ground further.