The research and development of innovative drug have progressed remarkably, but the long development circle and high failure rate have become the bottleneck. Drug repurposing, discovering new indications of approved drugs, is a strategy to overcome these obstacles. By exploring new indications for approved drugs, rapid progress has been made in basic research and clinical translation in recent years. Rich resources of drugs, proven security, efficient development workflow and reduced cost are core advantages of this strategy, making the strategy a crucial direction of optimizing the pipeline of drug research and development. This review systematically summarizes drug repurposing cases that have received clinical approval over the past five years, and proposes core strategies for drug repurposing, including approaches based on targets, pathways, drug similarity, post-treatment phenotypes, and clinical side effects, aiming to provide some strategic guidance for drug repurposing efforts.

[Abstract ] CHD1L is a newly identified oncogene located at Chr 1q21,its oncogenic role in tumorigenesis is through unleashed cell proliferation, G1/S transition, inhibition of apoptosis and Chromatin instability .It is an independent biomarker that can affect tumour′s process, prognosis and survival rate.The underlying mechanisms of CHD1L activation may disrupt the cell death program via binding the apoptotic protein Nur77 or exterting relevant function by mediate CHD 1L′s target genes (ARHGEF9, TCTP, SPOCK1, and NTKL) .This paper mainly introduces its oncogenic role and research progress of related molecular mechanism .

ObjectiveTo investigate the application value of selfmade modified hepatic pedicle occluding band in laparoscopic special section hepatectomy.MethodsForty-ifve patients who underwent laparoscopic special section hepatectomy in the Second Afifliated Hospital of Nanchang University between July 2014 and July 2015 were enrolled in this prospective study. The informed consents of all patients were obtained and the local ethical committee approval was received. Among the patients, 17 were males and 28 were females with the age ranging from 28 to 71 years old and the median of 50 years old. Five cases underwent resection of segmentⅣb, 8 of segmentⅤ, 10 of segmentⅦ, 9 of segmentⅧ, 8 of segmentⅥ+Ⅶ, and 5 of segmentⅤ+Ⅶ. According to the random number table method, the patients were divided into the group of hepatic inlfow occlusion with the selfmade modiifed hepatic pedicle occluding band (the modiifed group,n=18) and the traditional surgery group (the traditional group,n=27). Hepatic inlfow was not occluded or was occluded by Pringle maneuver in the traditional group. The length of operation, intraoperative blood loss and postoperative length of stay in two groups were compared usingt test.ResultsThe patients in both groups completed the surgery successfully. No conversion to laparotomy was observed in the modiifed group, while the rate of conversion to laparotomy in the traditional group was 22%(6/27). The length of operation, intraoperative blood loss and postoperative length of stay in the modiifed group were respectively (226±95) min, (421±90) ml and (10±4) d, while those in the traditional group were respectively (286±95) min, (501±91) ml and (14±4) d, and signiifcant differences were observed (t=-2.104,-2.899,-2.913;P<0.05).Conclusions The application of selfmade modified hepatic pedicle occluding band in laparoscopic special section hepatectomy is safe and feasible. And it can conveniently and effectively control the hepatic inlfow.