Environmental and Health Impacts of Pesticide-Based Malaria Control in Low- and Middle-Income Countries: A Scoping Review Introduction Malaria remains a major public health challenge in tropical and subtropical regions, necessitating effective vector control strategies. This scoping review aims to evaluate the environmental and health impacts of pesticide-based malaria control in low-and middle-income countries (LMICs). Methods A comprehensive search was conducted across Scopus, Web of Science and PubMed for studies published between 2004 and 2024, using a predefined search string based on the PEO framework. Inclusion criteria focused on studies addressing malaria control programmes and their effects on the environment and human health. Data extraction followed PRISMA 2020 guidelines. Results 12 studies were included, most of which focused on indoor residual spraying (IRS) and insecticide-treated nets (ITNs). The review identified significant direct and indirect impacts. While effective in reducing malaria transmission, IRS and ITNs pose substantial risks. Direct health effects included acute poisoning and long-term neurodevelopmental issues linked to pesticide exposure, with residues detected in breast milk. Environmental impacts included soil and water contamination, biodiversity loss and ecological disruption. The overlap of pesticide use in malaria control and agriculture was found to exacerbate insecticide resistance in mosquito populations. Conclusions Pesticide-based malaria control, while crucial, carries significant unintended consequences for human health and the environment. The findings underscore the urgent need for Integrated Vector Management (IVM) strategies that reduce reliance on chemical pesticides, mitigate resistance, and ensure environmental sustainability and public health safety.

Introduction: This study looks at the patient’s perspective to determine the Catastrophic Health Expenditure (CHE) level and the possible factors which can be associated with CHE in cancer patients. Methods: This cross sectional study was done in National Cancer Institute, Malaysia with 206 patients sampled using the multilevel sampling method and data collected from interview with patients using a validated questionnaire. The CHE definition used in this study is when the monthly health expenditure exceeds more than 10% of the monthly household income. Results: This study showed a CHE level of 26.2%. CHE was higher in Indian ethnicity (P = 0.017), single marital status (P = 0.019), poverty income (P < 0.001), small household size (P = 0.006) and without Guarantee Letter (GL) (P = 0.002) groups. The significant predicting factors were poverty income aOR 5.60 (95% CI: 2.34 – 13.39), home distance near to hospital aOR 4.12 (95% CI: 1.74 – 9.76), small household size aOR 4.59 (95% CI: 1.07 – 19.72) and lack of Guarantee Letter aOR 3.21 (95% CI: 1.24 – 8.30). Conclusion: The information from this paper can be used by policy makers to formulate better strategies in terms of health financing so that high risk for CHE cancer patients groups can be protected under a better health financing system.

CARIES INCREMENT AMONG SCHOOLCHILDREN EXPOSED TO DIFFERENT FLUORIDE CONCENTRATIONS IN WATER: A FIVE-YEAR RETROSPECTIVE COHORT STUDY Previous studies have indicated that the cessation of community water fluoridation (CWF) leads to an increase in caries prevalence among schoolchildren. However, little is known about the rate of caries progression among schoolchildren exposed to different concentrations of fluoride in water. Hence, this study aimed to compare the mean caries increment in permanent dentition among Malaysian schoolchildren with partial exposure (in Pahang) and full exposure (in Perak) to CWF and determine its associated factors. This was a five-year retrospective cohort study using an analysis of secondary data of school dental records among schoolchildren exposed to different fluoride concentrations in the water supply. Children in Perak were exposed to CWF throughout life while children in Pahang were exposed to CWF for the first five to six years of their lives before it was discontinued. The children were followed retrospectively from 2015 (initially aged eight years old) to 2019 (12 years old). Relevant data such as demographic characteristics, caries experience and exposure to other clinical preventive dental treatments were extracted and analysed using SPSS 21.0. Descriptive, independent t-test and negative binomial regression were used to examine the data. The sample consisted of 462 school dental records in both states. The prevalence of schoolchildren with DMFT scores of 2 and ≥ 3 increased by 10.4% and 13.9%, respectively, in Pahang from 2015 to 2019, compared to 4.8% and 0.9% in Perak. The mean (M) and standard deviation (SD) of caries increment at tooth and surface levels in permanent dentition among schoolchildren in Pahang (M = 0.83, SD = ±1.50 and M = 1.00, SD = ±2.10) was significantly greater (p < 0.001) compared to Perak (M = 0.18, SD = ±0.53 and M = 0.22, SD = ±0.66) over the same period. After controlling for confounders, partial exposure to CWF remained a strong predictor for mean caries increment over a five-year study period. This study showed greater mean caries increment in permanent dentition among schoolchildren in Pahang after CWF ceased. Hence, the findings from this study could be used to assist policy makers to support reimplementation and continuation of CWF in Malaysia.

COST ANALYSIS OF COMMUNITY WATER FLUORIDATION IN KERIAN, PERAK There is limited information available regarding the cost of community water fluoridation (CWF) in Malaysia. Issues related to the cessation of CWF since 2012 in one of the states in Malaysia, were due to the cost of fluoride chemical and the privatisation of water treatment facilities (WTF). Hence, this study aims to estimate the total and per capita cost of the CWF programme in Kerian, Perak, from 2015 to 2019. This was a retrospective record review, analysing CWF expenditure data in two WTF and two dental clinics in Kerian, Perak, from 2015 to 2019, using a healthcare provider perspective. The data on the population coverage of CWF in Kerian was obtained from the Perak Dental Division. Activity-based costing followed CWF guidelines for implementation, operation and maintenance, monitoring, and evaluation activities. All cost items (capital, manpower, safety, maintenance, chemical, and transportation) were presented in MYR 2015 with a 3.0% discount rate. Over the five-year period, the cost of the CWF programme was estimated as follows: MYR 242,644.33 (20.4%) for programme implementation, MYR 796,627.93 (66.9%) for programme operation and maintenance, MYR 147,542.05 (12.4%) for programme monitoring, and the remaining MYR 3,508.20 (0.3%) for programme evaluation. The highest contributor to the CWF programme cost was the fluoride chemical; sodium fluorosilicate, at MYR 450,364.53 (37.8%). The population that received fluoridated water was 189,015. From 2015 to 2019, the CWF programme in Kerian, Perak, incurred an estimated total cost of MYR 1,190,322.51, with a cost per capita of MYR 6.30. This cost analysis enables oral health policymakers and WTF authorities to make informed decisions about investing in the CWF programme.

Introduction: : Influenza is an upper respiratory infection is caused by the influenza virus. It occurs throughout the whole year in Malaysia with occasional outbreaks. Influenza-like illnesses (ILI) are generally treated as outpatient care while the more severe (SARI) is managed in patient care. The Casemix system, used in healthcare professionals' practices, may help in estimating the cost of influenza management. Methods: : This cross-sectional study extracts the cost of influenza management from different public hospitals in years 2016, 2017 and 2018. Data used selected ICD-10 codes, and the cost was abstracted from Malaysian Diagnostic Related Groups (MyDRG) software. The secondary data are from 2 sources, an urban teaching hospital Hospital Cancellor Tuanku Muhriz (HCTM) and Ministry of Health (MoH) inpatient hospitals database. The sample size of the study was 586, while a structured datasheet collating patients' sociodemographic data and cost of admission, per case, was obtained from the MyDRG software. Microsoft Excel and SPSS software were used in the analysis. Results: : Most influenza cases (61.8%) are between the ages of 0 and 10, Malays, and have similar gender proportions. Overall, the influenza treatment cost for inpatient care, totalled to RM 294,017,112. In 2018, the GDP for health consumed 3.76% of Malaysia's GDP income of RM 1.4 trillion, with an estimated RM 60,339 million used for health. Thus, the three-year public cost consumed 0.5% of 2018 GDP. Conclusion: Influenza screening at the primary healthcare setting, health education and treatment compliance should be scale-up to minimize the cost of influenza management of the public providers.

Introduction: There has been growing recognition linking spread of COVID-19 with environmental factors. One of the environmental factors with robust epidemiological literature supporting its role in diseases is the housing or built environment. COVID-19 spread has been found to occur mostly at homes through secondary household transmission. As most people spend more times inside homes during the pandemic, household remains an important site of COVID-19 spread. The aim of this study is to examine how housing and indoor factors affect the transmission and spread of COVID-19. Methods: This review employed a comprehensive search strategy to gather a broad range of scholarly articles and grey literature to provide a comprehensive understanding of the housing-related aspects of COVID-19 transmission. Results: Three electronic databases (Web of Science, Scopus, and PubMed) were searched using specific keywords related to COVID-19, housing, residents, neighborhoods, and indoor environments. Additionally, a supplementary literature survey was conducted to include relevant grey literature sources Conclusions This article summarizes the housing indoor factors involved in COVID-19 transmission, including the role of transmission from contaminated household surfaces. Indoor transmission of COVID-19 is found to be more likely due to contact transmission and close-contact aerosol transmission in a crowded, confined, and poorly ventilated indoor environment, related to poor housing condition. Whilst role of spread through contaminated household surfaces is of low probability. Based on this review, it can be suggested that besides the existing measures including avoiding crowding, close contacts and proper ventilation, specific standards for indoor environmental quality control and housing condition might be required. Housing is a public health issue and healthy housing is of universal concern.

Introduction: Influenza outbreak causes high economic burden to Malaysia and other countries in South East Asia. Scientists have found a relatively new way to detect influenza outbreaks early thus reducing the burden of disease by early intervention. This new technology is a social network information system which uses Facebook or Twitter data to detect potential influenza cases. Such system is good to be developed by the Malaysian government as it can detect influenza outbreaks three weeks earlier than the normal pathway. However, to implement this we require good evidence that the development will be accepted by potential users. Objective: This study was looking at the acceptance towards using social network information system among public health workers. Materials and Method: This study was done on 205 Malaysian One Health University Network (MyOHUN) members through email and physical survey. Results: Results show that 62.4% public health workers accepted the use technology. The acceptance was shown to be associated with performance expectancy (p<0.05). However, unlike the very famous Unified Theory of Acceptance and Use of Technology (UTAUT) model, the acceptance of social network information system was not associated with effort expectancy, social factors, facilitating conditions and socio-demographic factors. Therefore, it is suggested that social network information system be developed by the authorities in Malaysia, and be developed in a way that the system could strongly increase performance in detection of outbreak earlier than the current normal pathways. As such the system to be accepted and used, it must be sensitive, specific and be able to detect influenza outbreak early Conclusion: The development of social network information system is feasible as it is highly accepted and it’s potential to improve early detection of influenza outbreak.

Chronic low back pain is a common and preventable complain amongworkers. Large amount of financial and benefit cost has been spent by the developed countries to prevent, treat and rehabilitate a large number of workers that are exposed to hazards attributing to low back pain. Efforts on primary prevention of low back pain has been challenging due to difficulties in affirming work-relatedness of chronic back pain among workers. As such, efforts have to be focused on the existing literatures to propose acceptable variables to define work-relatedness specific to occupational low back pain. Evidences suggest twisting, frequent manual lifting of objects, duration of daily exposure, coping mechanism towards the pain, body mass index (BMI), smoking status and physical activity are associated with occupational back pain. However, further research efforts are needed to establish stronger evidence and improve the occupational safety and health of our workers that are exposed to all these hazards throughout the day on a daily basis.

In the absence of objective definition of work- relatedness; decision- making processes, assessments, investigations, treatment and rehabilitation on chronic back pain due to work had been challenging. BACKS questionnaire was designed to assist physicians in determining occupational low back pain among employees from the aspect of reliability and validity. Each identified employee with history of chronic back pain was given chronic back pain was given the BACKS Tool prototype to be filled in. Data was analyzed via stepwise linear regression to develop a temporary model for the BACKS Tool questionnaire. A total 220 respondents were included in the study. Among the associated factors of chronic occupational back pain were physical demand, psychological demand, colleagues who complain of similar back pain, job task involved in twisting for more than 20o, age of the employees and Pain Score that was reported by the respective employees. The regression reported sensitivity of 90.9% and specificity of 95.5%. In search of determining work- relatedness among employees with occupational back pain versus those due to aging, a screening tool had to be developed to assist in providing scientific assessments that would improve employee satisfaction during educational promotion and counseling.

In a country that struggles on safety standards and relying heavily on manual labour, Malaysia over the decade had to be very objective in defining work- relatedness among musculoskeletal disorder cases especially chronic low back pain. The BACKS questionnaire was a proposed Back Apparatus; a Collaboration between National University of Malaysia Medical Centre (UKMMC) with Malaysian Social Security Organization (SOCSO) to assist in determining occupational chronic back pain. In the questionnaire, chronic back pain was defined as minimal cumulative back pain for more than 2 weeks in the past year, Pain Visual Analog Score above 2 cm and Oswestry Disability Index of above 20%. Based on the SOCSO registry from 2008 to 2010, 428 (56.3%) workers of 760 workers with back pain agreed and met the requirements of our study. According to the standards of the Medical Board, the BACKS Tool reported a sensitivity of 62.7%, specificity of 94.5%, positive- predictive value (PPV) of 92.9% and negative- predictive value (NPV) of 69.0% with moderate agreement as Kappa value was 0.56. The BACKS Tool served as a complementary assessment along with visits to the workplace that has its advantages when one would to conduct a self- administered assessment of their workplace by safety and health officers, organizations with limited funding.