Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Based on health related theory of political economy,the discussion was carried out by combining theoretical research with literature analysis to explore Marx's methodology of political economy of health and its comtemporory implications.Marx applied the world outlook and methodology of dialectical and historical materialism and found out the essence of health and health care in capitalist society.His methodology of political economy of health contains the characteristics of totality and coherence,which is the organic synthesis of the two,It has important implications for the development of political economy of health in the new era.

Amartya Sen's capabilities approach was deeply favored by academic comnmunity since developed.Martha Nussbaum had made great contribution on the implementation of capabilities approach.The capabilities approach was emphasized and analyzed by many foreign health econometrists,which had great value of application in health field.It briefly discussed the development of capabilities theories and described the application of capabilities approach in health economics.

Objective: The aim of this study was to investigate whether genetic variability in the protocadherin 15 (PCDH15) gene may correspond with increased susceptibility to noise-induced hearing loss (NIHL) in a Chinese population. Methods: A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory of Henan province in China from January 1, 2006 to December 31, 2015. In this study, 394 cases who had an average hearing threshold of more than 40 dB (A) in high frequency were defined as the case group, and 721 controls who had an average hearing threshold of less than 35 dB (A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group. A questionnaire was completed by participants and a physical test was also conducted. SNP genotyping was performed using the SNPscan^TM Kit. Multivariate unconditional logistic regression additive models were used to analyze the genotypes in different groups, and the association with NIHL. Unconditional logistic regression models were used to assess the associations between the genotypes and NIHL. Results: The average age of study participants was (40.5±8.3) years and the median number of noise-exposed working years M (P₂₅, P₇₅) was 21.1 (9.1, 27.3). The range of noise exposed levels and the levels of cumulative noise exposure (CNE) were 80.1- 98.8 dB(A) and 86.6- 111.2 dB(A), respectively. Only the distribution of the genotypes (TT/CC/CT) of rs11004085 in the PCDH15 gene showed a significant difference between the case and control groups (P=0.049). In the case group, the distribution was 370 (93.9%), 24 (6.1%) and 0; in the control group, the distribution was 694 (96.3%), 23 (3.2%) and 1 (0.1% ). After smoking, drinking, hypertension, height and CNE adjustment, compared with the TT genotype individuals with the CC/CT genotype had a 1.90-fold increased risk of NIHL (95% CI: 1.06- 3.40). After stratified these data by the noise exposure level or CNE when the noise exposure level was>85 dB (A), compared with cases with the AA genotype of rs10825113, individuals with the GA/GG genotype had a 2.63-fold increased risk of NIHL (95% CI: 1.12- 6.14). When the CNE was ≤ 98 dB(A), compared with cases with the TT genotype of rs11004085, individuals with the CC/CT genotype had a 2.96-fold increased risk of NIHL (95% CI: 1.33- 6.56). However, these differences were not significant after Bonferroni correction had been applied. Conclusions The results confirmed that genetic variation within the PCDH15 gene may affect the susceptibility to NIHL.