Adenosquamous carcinoma is a rare variant of squamous cell carcinoma of the nasal septum which is very aggressive and metastasise early with poor prognosis. We present a case of a gentleman who presented with left nasal septal swelling for 4 months. Examination showed a lesion at the left nasal septum extending to the dorsum of the nose and right upper lip region. Computed tomography scan of the paranasal sinuses and neck showed an enhancing lesion with ulceration at the left nasal septum, with regional metastasis to the neck. He underwent a subtotal rhinectomy, inferior maxillectomy, and bilateral modified radical neck dissection type III. Unfortunately, he succumbed to a cardiac arrest 5 days after surgery.
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