Objective To study the relationship between lipid metabolism and liver function indexes in prediabetic population,and explore the predictive value of these indexes for prediabetes.Methods 546 patients with prediabetes who underwent physical examination in the First Affiliated Hospital of Xi'an Jiaotong University from April 2020 to August 2021 were selected as case group(PreDM group)and 546 patients with normal glucose tolerance as control group(NGT group).There was no significant difference in baseline data between the two groups after tendency matching score.The levels of lipid metabolism and liver function indicators were compared between the two groups;the correlation between lipid metabolism and liver function indicators in the PreDM group was analyzed;the influencing factors of prediabetes were screened by using binary logistic regression analysis;the predictive effect of lipid metabolism and liver function indicators on prediabetes was judged by using the ROC curve.Results Glutamic pyruvic transaminase(ALT),glutamic pyruvic transaminase/glutamic oxaloacetic transaminase ratio(ALT/AST),cholinesterase(CHE),gamma glutamyltransferase(GGT),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),total cholesterol/high density lipoprotein cholesterol ratio(TC/HDL-C)and triglyceride/high density lipoprotein cholesterol ratio(TG/HDL-C)in PreDM group were higher than those in NGT group(all P＜0.05).Spearman correlation analysis showed that TG/HDL-C in PreDM group had the positive correlation with ALT,ALT/AST,CHE and GGT(r=0.256,0.256,0.293,0.122,all P＜0.05).Multivariate stepwise logistic regression analysis showed that ALT/AST,GGT,TC/HDL-C and TG/HDL-C had the greatest effect on prediabetes(OR=2.124,1.027,1.196,1.260),and the combination of the four had the highest differential diagnostic value(AUC＞0.70).Conclusion There are more abnormal indexes of blood lipid and liver zymogram in prediabetic population,and the combination of ALT/AST,GGT,TC/HDL-C and TG/HDL-C is more effective in predicting prediabetes.

To evaluate the medication for one patient with the infection by carbapenem-resistant escherichia coli (CRE) to provide reference for the treatment of drug-resistance bacteria in clinical practice. During the development of anti-infective treatment regimen, clinical pharmacists analyzed and evaluated the situation, and provided suggestions for the medication:amikacin combined with fosfomycin and tigecycline. Physician adopted the recommendations,and the infective symptoms obtained a better control. The participation of clinical pharmacists in the treatment of intractable infection practice can provide reasonable and effective medication recommendations for clinics to improve anti-infective effectiveness in clinics.

Objective:To discuss the risk factors in lung cancer patients with chemotherapy-induced severe neutropenia to provide reference for clinical drug use. Methods:A retrospective analysis was performed for the patients with lung cancer,and the risk factors of severe neutropenia were statistically analyzed and found out. Results:The results of single factor experiments showed that the incidence of severe neutropenia was related with radiotherapy history,cycles of chemotherapy and the use time of granulocyte colony factor. Based on a binary logistic regression analysis,the history of radiotherapy and the use of granulocyte colony factor were the significant risk factors of severe neutropenia in the lung cancer patients. Conclusion:For the patients with radiotherapy history,it is better to choose chemotherapy drugs with lower toxicity,decrease drug dosage or preventively use granulocyte colony factor. The rational use of rhG-CSF can alleviate chemotherapy-induced severe neutropenia.