Background and Rationale: : Helicobacter pylori (Hp) is a gram-negative bacterium infecting over half of the global population (approximately 4.4 billion people in 2015) and represents the most prevalent chronic bacterial infection worldwide. Hp is classified as a human carcinogen, responsible for about 5.5% of all malignancies and 80–90% of the global gastric cancer (GC) burden, which ranks as the third leading cause of cancer-related mortality. Objectives: : This study aimed to evaluate the outcomes of antibiotic treatment for Helicobacter pylori infection through stool antigen detection in symptomatic Lao patients attending the Department of Gastroenterology at Setthathilath Hospital, Vientiane capital, Lao PDR Methodology: : A prospective descriptive study was conducted, collecting data via face-to-face interviews using a structured questionnaire. Patients received standard triple therapy consisting of Esomeprazole, Amoxycillin and Clarythomycin. Results: : The study enrolled 110 participants, predominantly female (56.4%) with ages ranging from 24 to 77 years and the majority (53.6%) aged between 36 and 55 years. Common clinical symptoms included epigastric pain (67.3%), fever (59.1%), melena (49.1%), bleeding per rectum (32.7%) and vomiting (31.8%). At the six month follow up, 52 patients (47.3%) were lost to follow up. Among the 58 patients who attended follow up, 87.9% tested negative for H. pylori stool antigen. Conclusion: Antibiotic therapy demonstrated high effectiveness in eradicating H.pylori infection among patients in Vientiane, with only seven individuals remaining positive at 6 months, likely due to treatment non-adherence.