Objective To investigate the effects of Jiawei Ditan Decoction on neurological function,pentraxin-3(PTX-3),and vascular endothelial growth factor(VEGF)in patients with post-ischemic stroke cognitive impairment(PSCI).Methods A total of 97 patients with PSCI who were admitted to Xuzhou Central Hospital from March 2022 to March 2024 were enrolled and randomly assigned to control group(n=48)or decoction group(n=49)using the envelope drawing method.The control group received conventional treatment,while the decoction group was additionally treated with Jiawei Ditan Decoction.Clinical efficacy,Traditional Chinese Medicine(TCM)syndrome scores,cognitive and functional assessments,laboratory markers,and oxidative stress levels were compared between the two groups.Results The total effective rate in the decoction group was significantly higher than that in the control group(P<0.05).At 3 and 6 months after treatment,TCM syndrome scores in the decoction group were lower than those in the control group(P<0.05).The scores of the Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE),and Barthel index(BI)in the decoction group were higher than those in the control group at 3 months after treatment,while the National Institutes of Health stroke scale(NIHSS)score in the decoction group was lower than that in the control group(P<0.05).At 1 month after treatment,PTX-3 and hypersensitive C-reactive protein(hs-CRP)levels in the decoction group were lower than those in the control group,while VEGF,superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and nitric oxide(NO)levels in the decoction group were higher than those in the control group(P<0.05).Conclusion Jiawei Ditan Decoction exhibits significant effects on improving neurological function and modulating PTX-3 and VEGF levels in patients with PSCI.

Objective : To investigate the effect of environmental enrichment on cognitive impairment and hippo- campus GAP-43 changes induced by exposure to obstructive sleep apnea-hypopnea syndrome ( OSAHS) during the period of late pregnancy in mice，and to explore relative inflammatory pathway mechanism． Methods : The experi- mental group of C57BL/6J pregnant mice were exposed to an intermittent hypoxic environment for 7 consecutive days starting from gestational day 15．The corresponding offspring were then placed in an enriched environment from postnatal day 21 to 2 months of age (designated as OSAHS + EE group) or in a normal environment (designat- ed as OSAHS group) ．Pregnant mice in the control group were maintained in a normal oxygen environment，and their corresponding offspring were placed in an enriched environment (designated as Control + EE group) or a nor- mal environment (designated as Control group) at the same ages．The spatial learning and memory ability of the mice was assessed by Morris water maze at the age of 2 months．The mRNA levels of NF-kB，NLRP3 and GAP-43 in the hippocampus were detected by real-time fluorescence quantitative PCR , and the protein levels of NLRP3 and GAP-43 in the hippocampus were detected by Western blot． Results: Compared with Control group，the swimming distance increased (P＜0. 01) ，and the percentage of swimming distance in target quadrant decreased (P＜0. 01) in OSAHS group．The level of NF - κB mRNA，NLRP3 mRNA and protein in the hippocampus was increased，and the level of GAP-43 mRNA and protein was decreased (P＜0. 01) ．Compared with the Control group，there were no significant differences in swimming distance，percentage of swimming distance，NF-κB mRNA，NLRP3 mRNA and protein content in the OSAHS + EE group． Conclusion OSAHS during pregnancy impairs the learning and memory ability of offspring mice and reduces the level of GAP-43 protein．The mechanism may be related to the in- crease of NF-κB / NLRP3 level，and environmental enrichment can improve the damage．

Objective To investigate the impact of carotid artery stenting (CAS) combined with hyperbaric oxygen (HBO) on cerebral hemodynamics in patients with internal carotid artery stenosis.Methods Seventy-eight patients with severe unilateral carotid artery stenosis were randomly divided into the control group (n =36) and the experimental group (n =42),which all received carotid artery stenting.After surgery,the control group was treated with anti-platelet and other routine treatment,while the experimental group received HBO therapy within 24 hours after surgery,in addition to routine treatment.Trancranial Doppler (TCD) and Computed tomography perfusion (CTP) were used to detect changes in cerebral hemodynamics both before and after surgery,as well as 2 weeks after surgery,and the rate of stroke recurrence was also observed within one year of surgery.Results Mean velocity (Vm) of blood flow,peak systolic velocity (PSV),pulse index (PI) and cerebrovascular reserve (CVR) of the affected middle cerebral artery were significantly increased after surgery.Moreover,2 weeks after surgery,regional cerebral blood volume and flow (rCBV and rCBF) of the experimental group were also significantly higher,as compared with those before surgery (P ＜ 0.05).Mean transit time (rMTT) and peak time (rTTP) were all lower than those before surgery.Changes in rCBF,rMTT and rTTP 2 weeks after surgery were all greater than those of the control group(P ＜ 0.05).Oneyear follow-up indicated that stroke recurrence rate of the experimental group was lower than that of the control group (11.9％ vs.16.7％,P ＜ 0.05).Conclusions Carotid artery stenting combined with HBO intervention could improve cerebral hemodynamics in patients with severe internal carotid artery stenosis,and at the same time could reduce stroke recurrence rate.

Objective To investigate the impact of carotid artery stenting (CAS) combined with hyperbaric oxygen (HBO) on cerebral hemodynamics in patients with internal carotid artery stenosis.Methods Seventy-eight patients with severe unilateral carotid artery stenosis were randomly divided into the control group (n =36) and the experimental group (n =42),which all received carotid artery stenting.After surgery,the control group was treated with anti-platelet and other routine treatment,while the experimental group received HBO therapy within 24 hours after surgery,in addition to routine treatment.Trancranial Doppler (TCD) and Computed tomography perfusion (CTP) were used to detect changes in cerebral hemodynamics both before and after surgery,as well as 2 weeks after surgery,and the rate of stroke recurrence was also observed within one year of surgery.Results Mean velocity (Vm) of blood flow,peak systolic velocity (PSV),pulse index (PI) and cerebrovascular reserve (CVR) of the affected middle cerebral artery were significantly increased after surgery.Moreover,2 weeks after surgery,regional cerebral blood volume and flow (rCBV and rCBF) of the experimental group were also significantly higher,as compared with those before surgery (P ＜ 0.05).Mean transit time (rMTT) and peak time (rTTP) were all lower than those before surgery.Changes in rCBF,rMTT and rTTP 2 weeks after surgery were all greater than those of the control group(P ＜ 0.05).Oneyear follow-up indicated that stroke recurrence rate of the experimental group was lower than that of the control group (11.9％ vs.16.7％,P ＜ 0.05).Conclusions Carotid artery stenting combined with HBO intervention could improve cerebral hemodynamics in patients with severe internal carotid artery stenosis,and at the same time could reduce stroke recurrence rate.