Background: Asymptomatic bacteriuria describes a condition in which urine culture reveals a significant growth of pathogenic bacteria, specifically greater than 105 of colony-forming units per millilitre of urine. It has a direct bearing on the health of a pregnant woman, her pregnancy and consequently the foetus. Thus, this study investigated the prevalence of asymptomatic bacteriuria of pregnancy in Raja Isteri Pengiran Anak Saleha (RIPAS) Hospital, the premiere tertiary hospital in Brunei Darussalam. Methods: A total of 170 pregnant women who were visiting the Department of Obstetrics and Gynaecology at RIPAS Hospital for routine antenatal care between February and March 2011 volunteered for this cross-sectional study. They did not present with any clinical symptoms of bacteriuria or indeed any other illness. They were investigated for bacteriuria by urine microscopy, culture, and sensitivity. Results: Urine samples from seven of the women produced significant bacterial growth, showing a prevalence of 4.1%. The organisms isolated were Klebsiella species (2.94%) and Escherichia coli (1.18%); these bacteria were both sensitive to amoxicillin, vancomycin, tetracycline, and erythromycin. Conclusion: Brunei has a similar prevalence of asymptomatic bacteriuria to other South-East Asian countries.

Introduction: The link between Chlamydia trachomatis (C. trachomatis) and ectopic pregnancy is mainly based on early sero-epidemiological case-control studies. Recent studies have shown divergent results concerning the risk of ectopic pregnancy following C. trachomatis infection. There has been no study done in Brunei to establish a correlation between the two. The purpose of this study was to de- termine whether chlamydial infection was more prevalent in young women with ectopic pregnancy at- tending RIPAS Hospital, Brunei Darussalam. Materials and Methods: This was a prospective study. All ectopic pregnancies encountered in RIPAS Hospital (January 2010 to December 2011) were included in the study. For comparison, 100 normal pregnancy cases were included. Endocervical swabs were taken and analysed with rapid immunoassay using Clearview Chlamydia MF®. Results were analysed using Fisher's exact test on Graphpad software®. Results: During the study period, a total of 123 ec- topic pregnancies were encountered. Majority of patients with ectopic and normal pregnancies were in the 25-30 and 31-36 year age groups. There were no significant differences observed between the two group in the age groups (p=0.468 for trend) and their nationalities (p=0.572 for trend). Among pa- tients with ectopic pregnancies, 6.5% (n=8) tested positive for Chlamydia infections compared to 5% (n=5) of normal pregnancies (p>0.05). Conclusion: There was no statistically significant difference in the incidence of Chlamydial infections between ectopic and normal pregnancies in our study.

Introduction: Uterine sarcomas are rare but aggressive malignant tumours of the smooth muscle or supporting tissues of the uterus. Currently, there are no published data available in Brunei Darussalam. This study was done to evaluate the demographic profile, risk factors, diagnostic issues and the clinical outcome of patients with uterine sarcomas in the Raja Isteri Pengiran Anak Saleha (RIPAS) hospital, a tertiary hospital in Brunei Darussalam. Patients and Methods: All patients with uterine sarcoma reg- istered in the Department of Obstetrics and Gynaecology during a period of ten years (2001 to 2010) were studied. Cases were identified through the Gynaecology Oncology registry and the case notes were retrospectively reviewed. Results: Over this period, there were 156 cases of uterine tumour and of these, 37 cases (23.7%) were uterine sarcoma. The majority were local (n=34, Bruneian 81.1%; 30 Malays and four Chinese) with a mean age of 47.8 years. High risk factors were identified in 29 (78.4%) patients. Abnormal uterine bleeding and mass per abdomen were the most common clinical presentations. A preoperative diagnosis was possible only in five cases (13.5%) and in two patients (5.4%) the diagnosis was suspected during surgery and confirmed by frozen section. At the completion of a five-year follow up in the first five year group (2001 to 2005) 62.5% patients are alive and disease free. There were six deaths from the disease during the entire study period. Conclusion: A high pro- portion of uterine tumours were uterine sarcoma. The majority of the patients (78.4%) had one or more risk factors. Unlike endometrial carcinoma a preoperative diagnosis is difficult in uterine sarcoma. At the time of this study 70.3% of patients with uterine sarcoma were alive and disease free.

Diagnosis, Differential ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local ; diagnosis ; drug therapy ; Tuberculosis, Pulmonary ; diagnosis ; Uterine Cervical Neoplasms ; drug therapy