Objective:To discuss the correlation of pathologic findings after radical prostatectomy and preoperative 18F-PSMA-1007 PET/CT parameters with the prognosis of patients with prostate cancer. Methods:A retrospective case series study was conducted. The clinicopathological data of 48 patients with prostate cancer who underwent radical prostatectomy in Shanxi Province Cancer Hospital between January 2019 and August 2023 were retrospectively analyzed. All patients underwent 18F-PSMA-1007 PET/CT imaging before surgery. The age, the preoperative serum total prostate-specific antigen (tPSA), prostate-specific antigen density (PSAD), prostate volume, tumor diameter, TNM staging, the pathologic data after radical prostatectomy [International Society of Urological Pathology (ISUP) grade, resection margin status, nerve invasion], and preoperative maximum standard uptake value (SUV max) were collected. The receiver operating characteristic (ROC) curves were used to evaluate the efficacy of PET/CT parameter SUV max in predicting tumor recurrence after prostate cancer surgery. The recurrence-free survival (RFS) was analyzed by using the Kaplan-Meier method and log-rank test was performed. Cox proportional risk model was used to analyze the factors influencing RFS after radical prostatectomy. Results:All 48 patients were acinar adenocarcinoma. The median level of the patients' serum tPSA was 19.16 (10.50, 30.99) ng/ml; the median prostate volume was 36.20 (31.83, 45.48) ml; the median tumor diameter was 2.80 (1.60, 4.00) cm; the median PSAD was 0.48 (0.31,1.02) ng·ml -1·cm -3. The primary SUV max of prostate cancer was 13.61 (8.10, 20.20) . Of the 48 patients, 1 case died of heart disease and 1 case died of COVID-19 within 3 to 6 months after surgery, and the rest 46 patients were analyzed for prognosis. Among 46 cases, 26 were in the ISUP low-grade group and 20 were in the high-grade group; 17 were positive and 29 were negative for nerve invasion; 7 were positive and 39 were negative for margin status. The median follow-up time was 18.5 (8-64) months. There were 30 recurrence-free patients and 16 recurrent patients by the follow-up in April 2024. The median RFS time was 15 months; and there were statistically significant differences in RSF among the ISUP high-grade and low-grade groups, preoperative SUV max ≥ 16.77 and < 16.77 groups, positive and negative resection margin groups (all P < 0.01). SUV max was positively correlated with ISUP pathological grade and tPSA level ( r value was 0.634, 0.584, respectively; both P < 0.01). The differences in preoperative serum tPSA level, PSAD, tumor diameter, and SUV max were statistically significant between the ISUP low-grade group and the high-grade group (all P < 0.01); the differences in preoperative serum tPSA, PSAD, and tumor diameter were statistically significant between the nerve invasion positive group and nerve invasion negative group (all P < 0.01); the differences in preoperative serum tPSA, PSAD, tumor diameter, and SUV max between patients with positive resection margins or not were not statistically significant (all P > 0.05). Multivariate Cox regression analysis showed that the tumor resection margin status (negativity vs. positivity: HR = 7.82,95% CI: 1.97-31.07, P < 0.01), ISUP pathological grade (low grade vs. high grade: HR = 4.34,95% CI:1.21-15.62, P < 0.05), and the preoperative SUV max (<16.77 vs. ≥ 16.77: HR = 4.18, 95% CI:1.36-12.85 , P < 0.05) were independent influencing factors for RFS in patients with prostate cancer after radical prostatectomy. Conclusions:Pathological grading after radical prostatectomy and the preoperative 18F-PSMA-1007 PET/CT parameters are associated with the prognosis of patients with prostate cancer.

Objective To explore the influencing factors of immune-associated thyroid dysfunction caused by sintilimab treatment in solid tumors and construct a prediction model.Methods Medical records of patients diagnosed with solid tumors and treated with sintilimab at Peking University People's Hospital(Xizhimen Campus,Tongzhou Campus,Shijiazhuang Campus)from January 2023 to September 2024 were collected to explore the influencing factors that caused immune-related thyroid dysfunction using univariate and multifactorial binary logistic regression analyses and to establish a prediction model.The predictive effect of the model was assessed using the receiver operating characteristic(ROC)curve.Results A total of 120 patients were included,and 33 presented with immune-related thyroid dysfunction.Multifactorial logistic regression analysis revealed that thyroid-stimulating hormone(TSH)[OR=2.470,95%CI=(1.279,4.771)]and treatment cycles[OR=1.298,95%CI=(1.117,1.509)]were independent risk factors for the occurrence of immune-associated thyroid dysfunction,and the difference was statistically significant(P＜0.05).The area under the ROC curve was(0.897±0.043)[95%CI=(0.813,0.981)],the Yoden index was 0.703,and the model prediction accuracy was 86.5%.Conclusion The risk of immune-related thyroid dysfunction caused by sintilimab is high,and TSH and treatment cycle are the influencing factors,and the constructed model has certain predictive value and is of reference significance.

Objective:Systematically integrate the real experience and multi-dimensional needs of patients with breast cancer related lymphedema (BCRL) in the process of self-management to provide reference for clinical development of targeted and systematic interventions.Methods:Computer searches were conducted on qualitative studies on the real experiences, psychological feelings, and multidimensional needs of BCRL patients during self-management in databases such as China National Knowledge Infrastructure, VIP Database, Wanfang Database, China Biomedical Literature Database, CINAHL, PubMed, Cochrane Library, Web of Science, and PsycINFO. The search period was from database establishment to January 31, 2024. According to the qualitative research quality evaluation criteria of the Joanna Briggs Institute Evidence Based Healthcare Center in Australia, the quality of literature was evaluated, and the results were analyzed and integrated using a pooled integration method.Results:A total of 10 articles were included, and 44 research results were extracted. Similar results were classified into 10 categories and synthesized into 3 integrated results, highlighting the difficulties and challenges encountered; need external multidimensional support and assistance; seeking a new normal and perceiving its benefits.Conclusions:BCRL patients face physical and mental challenges in their lifelong self-management process. Hospitals, society, and related institutions should attach importance to and pay attention to the needs, burdens, and beneficial experiences of patients, provide them with more professional guidance and supervision, and collaborate with families and peers to provide support and encouragement, helping patients reduce negative emotions and strengthen coping abilities, thereby improving overall quality of life.

Objective:To investigate the effects of golden cicada anti-itch capsules combined with tacrolimus ointment on clinical symptoms and T helper cell type 1/T helper cell type 2 (Th1/Th2) cytokine balance in older adult patients with itchy skin.Methods:This prospective study included 80 older adult patients with itchy skin who attended No. 215 Hospital of Shaanxi Nuclear Industry from January 2022 to January 2024. The patients were randomly divided into two groups ( n = 40 per group) using a random number table method. The ointment group received tacrolimus ointment, while the combination group was treated with golden cicada anti-itch capsules plus tacrolimus ointment. Both groups were treated for 4 weeks. Clinical symptom scores, Dermatology Life Quality Index (DLQI) scores, traditional Chinese medicine (TCM) syndrome scores, and the cytokine profiles of Th1 [interleukin-2 (IL-2) and interferon-gamma (IFN-γ)]/Th2 [interleukin-5 (IL-5), interleukin-13 (IL-13)] and skin barrier function were compared before and after 4 weeks of treatment. The incidence of adverse reactions and recurrence rates were recorded. Results:Before treatment, there were no statistically significant differences in clinical symptom scores, DLQI scores, or TCM syndrome scores between the ointment and combination groups ( t = -0.76, 0.76, -0.54, 0.33,-0.16, -0.36, all P > 0.0.5). After treatment, both groups showed reductions in severity of itching, duration, frequency of episodes, and area of skin lesions, as well as DLQI scores and TCM syndrome scores ( t = 16.14, 24.18, 14.65, 19.98, 18.21, 25.03, 15.42, 19.55, 12.36, 18.14, 15.65, 22.05, all P < 0.05). After treatment, the combination group had lower scores for severity of itching [(0.88 ± 0.24) points], duration [(0.91 ± 0.22) points], frequency of episodes [(1.06 ± 0.21) points], area of skin lesions [(1.18 ± 0.31) points], DLQI [(7.93 ± 2.17) points], and TCM syndrome scores [(8.89 ± 1.47) points] compared with the ointment group [(1.17 ± 0.33) points, (1.44 ± 0.26) points, (1.43 ± 0.25) points, (1.72 ± 0.44) points, (11.41 ± 3.05) points, (13.32 ± 2.06) points, t = 4.50, 9.84, 7.17, 6.35, 5.88, 11.07, all P < 0.05]. Before treatment, there was no statistically significant difference in Th1/Th2 cytokine level between the ointment and combination groups ( t = -0.15, -0.07, 0.21, -0.23, all P > 0.05). Both groups showed significant decreases in IL-2 and IFN-γ levels, and increases in IL-5 and IL-13 levels after treatment compared with their pre-treatment levels ( t = 4.56, 9.02, 11.11, 15.20, -5.63, -9.14, -6.01, -8.88, all P < 0.05). After treatment, the combination group had significantly lower IL-2 and IFN-γ levels and significantly higher IL-5 and IL-13 levels compared with the ointment group ( t = 7.25, 7.13, -6.69, -7.67, all P < 0.05). Before treatment, there was no statistically significant difference in skin barrier function between the two groups ( t = -0.16, 0.25, P > 0.05). After treatment, both groups exhibited significant reductions in transepidermal water loss and significant increases in stratum corneum hydration compared with their pre-treatment levels ( t = 6.25, 11.04, -4.82, -9.77, all P < 0.05). After treatment, the combination group demonstrated significantly lower transepidermal water loss and significantly greater stratum corneum hydration than the ointment group ( t = 4.13, 7.73, both P < 0.05). There was no significant difference in incidence of adverse reactions between the ointment group [7.50% (3/40)] and the combination group [12.50% (5/40), χ2 = 0.56, P = 0.456]. The recurrence rate was 27.50% (11/40) in the ointment group and 10.00% (4/40) in the combination group. Six months after treatment, the difference in recurrence rate between the ointment and combination groups was statistically significant ( χ2 = 4.02, P = 0.045). Conclusions:The use of Golden Cicada anti-itch capsules combined with tacrolimus ointment for treating itchy skin in older adult patients can help relieve clinical symptoms, improve skin barrier function, promote Th1/Th2 cytokine balance, and decrease the recurrence rate.

Objective:Systematic evaluation and integration of the real experience of dietary restriction in patients with inflammatory bowel disease, providing reference for the development of targeted intervention strategies.Methods:Qualitative studies on the dietary restriction experience of patients with inflammatory bowel disease retrieved from PubMed, Cochrane Library, Web of Science, Embase, CINAHL, China National Knowledge Infrastructure, Wanfang, VIP, and Chinese Biomedical Literature Database using computer search. The search period was from the establishment of the database to May 31, 2024. According to the Australian Joanna Briggs Institute Evidence Based Healthcare Center Qualitative Research Quality Evaluation Criteria, the quality of included literature was evaluated, and the results were subjected to meta-analysis using a pooled integration method.Results:A total of 9 studies were included, and 36 research results were extracted and summarized into 9 categories. Then, three integrated results were further synthesized, namely physical and mental impairment and social limitation; change attitude and actively explore; seeking external support to promote beneficial growth.Conclusions:Dietary restrictions for inflammatory bowel disease have various impacts on patients. Medical staff should focus on the nutritional status and emotional needs of patients, and provide multidimensional social support based on their actual dietary management experience. They should develop patient-centered personalized intervention measures to help patients achieve more scientific and effective dietary management and improve their overall quality of life.

Objective:To discuss the correlation of International Society of Urological Pathology (ISUP) pathological grading with 18F-prostate specific membrane antigen (PSMA)-1007 positron emission tomography-computed tomography (PET/CT) parameters and serum total prostate specific antigen (tPSA) in prostate cancer, and assess the clinical value of PET/CT combined with tPSA in predicting the ISUP pathological grade of prostate cancer. Methods:The correlation of ISUP pathological grade with primary parameters of PET/CT images and serum tPSA of 117 patients diagnosed with prostate cancer at Shanxi Cancer Hospital from August 2018 to February 2023 and taken 18F-PSMA-1007 PET/CT imaging were retrospectively analyzed. Univariate and multivariate logistic regressions were used to identify the independent influencing factors for ISUP pathological grading of prostate cancer. The receiver operating characteristic (ROC) curves were used to predict the efficacy between the high and low ISUP grades for prostate cancer. Results:Of the 117 patients, 20 were in ISUP Group 1, 25 in Group 2, 18 in Group 3, 32 in Group 4, and 22 in Group 5. Of these, 63 were in the low-grade group (Groups 1-3) and 54 were in the high-grade group (Groups 4-5). The tumor long diameter was 3.10 (2.05, 4.25) cm, the prostate volume was 40.11 (33.13, 51.85) cm 3, the serum tPSA was 19.71 (12.25, 42.83) ng/ml, the prostate specific antigen density (PSAD) was 0.51 (0.31, 1.01) ng·ml -1·cm -3, the maximum standard uptake value of the lesion (SUVmax) was 15.24 (10.87, 22.03), and the tumor/spleen uptake ratio (TSR) was 1.61 (1.08, 2.15) in the 117 patients. The correlation analysis displayed that the SUVmax, TSR, and tPSA were positively correlated with ISUP groups ( r=0.640, 0.619, and 0.500, P＜0.01). The differences among SUVmax, TSR, long diameter, tPSA, and PSAD were statistically significant when compared among the five ISUP groups ( H=48.98, 45.63, 26.82, 33.95, and 23.81, P＜0.001). The differencesin serum tPSA ( z=5.19), PSAD ( z=4.64), long diameter ( z=3.19), SUVmax ( z=5.57), and TSR ( z=5.53) of the patients between the low-grade group and the high-grade group were statistically significant ( P＜0.01). In multivariate analysis, TSR ( OR=4.172, 95% CI: 2.095-8.308, P＜0.001) and the serum tPSA ( OR=1.042, 95% CI: 1.014-1.070, P＜0.01) were independent influencing factors for ISUP grades. ROC analysis revealed that the area under the curve for the 18F-PSMA-1007 PET/CT parameters SUVmax and TSR to predict low- or high-grade ISUP for prostate cancer was 0.800 (95% CI: 0.717-0.883) and 0.797 (95% CI: 0.713-0.881), respectively. Among the 70 patients who underwent radical prostatectomy, the postoperative recurrence rate of high-grade ISUP patients was higher than that of low-grade patients (54.8% and 25.6%, χ 2=6.21, P＜0.05). Conclusions:18F-PSMA-1007 PET/CT has good application in predicting ISUP grading of prostate cancer. TSR and the serum tPSA are independent predictors for the pathological grade.

Objective To explore the influencing factors of immune-associated thyroid dysfunction caused by sintilimab treatment in solid tumors and construct a prediction model.Methods Medical records of patients diagnosed with solid tumors and treated with sintilimab at Peking University People's Hospital(Xizhimen Campus,Tongzhou Campus,Shijiazhuang Campus)from January 2023 to September 2024 were collected to explore the influencing factors that caused immune-related thyroid dysfunction using univariate and multifactorial binary logistic regression analyses and to establish a prediction model.The predictive effect of the model was assessed using the receiver operating characteristic(ROC)curve.Results A total of 120 patients were included,and 33 presented with immune-related thyroid dysfunction.Multifactorial logistic regression analysis revealed that thyroid-stimulating hormone(TSH)[OR=2.470,95%CI=(1.279,4.771)]and treatment cycles[OR=1.298,95%CI=(1.117,1.509)]were independent risk factors for the occurrence of immune-associated thyroid dysfunction,and the difference was statistically significant(P＜0.05).The area under the ROC curve was(0.897±0.043)[95%CI=(0.813,0.981)],the Yoden index was 0.703,and the model prediction accuracy was 86.5%.Conclusion The risk of immune-related thyroid dysfunction caused by sintilimab is high,and TSH and treatment cycle are the influencing factors,and the constructed model has certain predictive value and is of reference significance.

Objective:Systematically integrate the real experience and multi-dimensional needs of patients with breast cancer related lymphedema (BCRL) in the process of self-management to provide reference for clinical development of targeted and systematic interventions.Methods:Computer searches were conducted on qualitative studies on the real experiences, psychological feelings, and multidimensional needs of BCRL patients during self-management in databases such as China National Knowledge Infrastructure, VIP Database, Wanfang Database, China Biomedical Literature Database, CINAHL, PubMed, Cochrane Library, Web of Science, and PsycINFO. The search period was from database establishment to January 31, 2024. According to the qualitative research quality evaluation criteria of the Joanna Briggs Institute Evidence Based Healthcare Center in Australia, the quality of literature was evaluated, and the results were analyzed and integrated using a pooled integration method.Results:A total of 10 articles were included, and 44 research results were extracted. Similar results were classified into 10 categories and synthesized into 3 integrated results, highlighting the difficulties and challenges encountered; need external multidimensional support and assistance; seeking a new normal and perceiving its benefits.Conclusions:BCRL patients face physical and mental challenges in their lifelong self-management process. Hospitals, society, and related institutions should attach importance to and pay attention to the needs, burdens, and beneficial experiences of patients, provide them with more professional guidance and supervision, and collaborate with families and peers to provide support and encouragement, helping patients reduce negative emotions and strengthen coping abilities, thereby improving overall quality of life.

Objective:To investigate the effects of golden cicada anti-itch capsules combined with tacrolimus ointment on clinical symptoms and T helper cell type 1/T helper cell type 2 (Th1/Th2) cytokine balance in older adult patients with itchy skin.Methods:This prospective study included 80 older adult patients with itchy skin who attended No. 215 Hospital of Shaanxi Nuclear Industry from January 2022 to January 2024. The patients were randomly divided into two groups ( n = 40 per group) using a random number table method. The ointment group received tacrolimus ointment, while the combination group was treated with golden cicada anti-itch capsules plus tacrolimus ointment. Both groups were treated for 4 weeks. Clinical symptom scores, Dermatology Life Quality Index (DLQI) scores, traditional Chinese medicine (TCM) syndrome scores, and the cytokine profiles of Th1 [interleukin-2 (IL-2) and interferon-gamma (IFN-γ)]/Th2 [interleukin-5 (IL-5), interleukin-13 (IL-13)] and skin barrier function were compared before and after 4 weeks of treatment. The incidence of adverse reactions and recurrence rates were recorded. Results:Before treatment, there were no statistically significant differences in clinical symptom scores, DLQI scores, or TCM syndrome scores between the ointment and combination groups ( t = -0.76, 0.76, -0.54, 0.33,-0.16, -0.36, all P > 0.0.5). After treatment, both groups showed reductions in severity of itching, duration, frequency of episodes, and area of skin lesions, as well as DLQI scores and TCM syndrome scores ( t = 16.14, 24.18, 14.65, 19.98, 18.21, 25.03, 15.42, 19.55, 12.36, 18.14, 15.65, 22.05, all P < 0.05). After treatment, the combination group had lower scores for severity of itching [(0.88 ± 0.24) points], duration [(0.91 ± 0.22) points], frequency of episodes [(1.06 ± 0.21) points], area of skin lesions [(1.18 ± 0.31) points], DLQI [(7.93 ± 2.17) points], and TCM syndrome scores [(8.89 ± 1.47) points] compared with the ointment group [(1.17 ± 0.33) points, (1.44 ± 0.26) points, (1.43 ± 0.25) points, (1.72 ± 0.44) points, (11.41 ± 3.05) points, (13.32 ± 2.06) points, t = 4.50, 9.84, 7.17, 6.35, 5.88, 11.07, all P < 0.05]. Before treatment, there was no statistically significant difference in Th1/Th2 cytokine level between the ointment and combination groups ( t = -0.15, -0.07, 0.21, -0.23, all P > 0.05). Both groups showed significant decreases in IL-2 and IFN-γ levels, and increases in IL-5 and IL-13 levels after treatment compared with their pre-treatment levels ( t = 4.56, 9.02, 11.11, 15.20, -5.63, -9.14, -6.01, -8.88, all P < 0.05). After treatment, the combination group had significantly lower IL-2 and IFN-γ levels and significantly higher IL-5 and IL-13 levels compared with the ointment group ( t = 7.25, 7.13, -6.69, -7.67, all P < 0.05). Before treatment, there was no statistically significant difference in skin barrier function between the two groups ( t = -0.16, 0.25, P > 0.05). After treatment, both groups exhibited significant reductions in transepidermal water loss and significant increases in stratum corneum hydration compared with their pre-treatment levels ( t = 6.25, 11.04, -4.82, -9.77, all P < 0.05). After treatment, the combination group demonstrated significantly lower transepidermal water loss and significantly greater stratum corneum hydration than the ointment group ( t = 4.13, 7.73, both P < 0.05). There was no significant difference in incidence of adverse reactions between the ointment group [7.50% (3/40)] and the combination group [12.50% (5/40), χ2 = 0.56, P = 0.456]. The recurrence rate was 27.50% (11/40) in the ointment group and 10.00% (4/40) in the combination group. Six months after treatment, the difference in recurrence rate between the ointment and combination groups was statistically significant ( χ2 = 4.02, P = 0.045). Conclusions:The use of Golden Cicada anti-itch capsules combined with tacrolimus ointment for treating itchy skin in older adult patients can help relieve clinical symptoms, improve skin barrier function, promote Th1/Th2 cytokine balance, and decrease the recurrence rate.

Objective:Systematic evaluation and integration of the real experience of dietary restriction in patients with inflammatory bowel disease, providing reference for the development of targeted intervention strategies.Methods:Qualitative studies on the dietary restriction experience of patients with inflammatory bowel disease retrieved from PubMed, Cochrane Library, Web of Science, Embase, CINAHL, China National Knowledge Infrastructure, Wanfang, VIP, and Chinese Biomedical Literature Database using computer search. The search period was from the establishment of the database to May 31, 2024. According to the Australian Joanna Briggs Institute Evidence Based Healthcare Center Qualitative Research Quality Evaluation Criteria, the quality of included literature was evaluated, and the results were subjected to meta-analysis using a pooled integration method.Results:A total of 9 studies were included, and 36 research results were extracted and summarized into 9 categories. Then, three integrated results were further synthesized, namely physical and mental impairment and social limitation; change attitude and actively explore; seeking external support to promote beneficial growth.Conclusions:Dietary restrictions for inflammatory bowel disease have various impacts on patients. Medical staff should focus on the nutritional status and emotional needs of patients, and provide multidimensional social support based on their actual dietary management experience. They should develop patient-centered personalized intervention measures to help patients achieve more scientific and effective dietary management and improve their overall quality of life.