Objective To evaluate the clinical efficacy of dynamic muscle-regulating acupuncture combined with warm needling in treating cervical spondylotic radiculopathy(CSR).Methods Sixty patients diagnosed with CSR at the Acupuncture Department of Dongguan Traditional Chinese Medicine Hospital from July to December 2024 were enrolled and randomly divided into an observation group and a control group using a random number table,with 30 cases in each group.The control group received warm needling therapy,while the observation group received additional dynamic muscle-regulating acupuncture.Treatments were administered three times weekly for a total of 10 sessions(one treatment course).After 10 sessions,clinical efficacy was evaluated,and total effective rates,changes in Yasuhiko Tanaka's cervical spondylosis symptom scale scores,Visual Analogue Scale(VAS)of pain scores were observed.The cervical range of motion(ROM),and incidence of adverse reactions were evaluated.Results(1)The total effective rate of the observation group was 93.33%(28/30),and the control group was 80.00%(24/30).The clinical efficacy of the observation group was superior to that of the control group,and the difference was statistically significant(P＜0.05).(2)After treatment,the cervical spondylosis symptom scale scores of Yasuhisa Tanaka in the two groups significantly improved(P＜0.05),and the observation group was significantly superior to the control group in improving the cervical spondylosis symptom scale scores of Yasuhisa Tanaka,with a statistically significant difference(P＜0.05).(3)After treatment,the VAS scores of patients in the two groups significantly improved(P＜0.05),and the observation group was significantly superior to the control group in improving the VAS scores,and the difference was statistically significant(P＜0.05).(4)After treatment,the cervical joint mobility of patients in the two groups significantly improved(P＜0.05),and the observation group was significantly superior to the control group in improving cervical joint mobility,with a statistically significant difference(P＜0.05).(5)The incidence rate of adverse reactions in the observation group was 3.33%(1/30);there were no adverse reaction events in the control group.The difference in the incidence rate of adverse reactions between the observation group and the control group was not statistically significant(P＞0.05).Conclusion The combination of dynamic muscle-regulating acupuncture and warm needling effectively improves cervical function,alleviates pain symptoms,and demonstrates high safety with significant clinical efficacy in treating CSR.

BACKGROUND:Previous studies have shown that minichromosome maintenance 3 is related with fluorosis, but the expression of minichromosome maintenance 3 in fluorosis patients is not clear yet.
OBJECTIVE:To analyze the mRNA expression level of minichromosome maintenance 3 in peripheral blood from patients exposed to fluoride and normal controls.
METHODS:Eleven patients with mild fluorosis by drinking water (exposure group) and 11 cases of control (non-exposure group) were selected for research. SYBRGreen1 real-time quantitative PCR was used to determine the mRNA expression of minichromosome maintenance 3 in peripheral blood mononuclear cel s, and the liver and renal function indicators were detected.
RESULTS AND CONCLUSION:mRNA expressions of minichromosome maintenance 3 in the exposure group and non-exposure group were (0.573 60±0.102 59) and (0.550 0±0.171 81), respectively, and there was no significant difference between two groups (P>0.05). There were no significant differences in the liver and renal function indicators between two groups. The results indicate that mild fluorosis has no significant effect on mRNA expression of minichromosome maintenance 3 in the peripheral blood mononuclear cel s. More indicators are needed to compressively analyze the effect of fluoride on the liver and renal functions.

OBJECTIVETo evaluate the potential role of BME-10X collagen/hydroxyapatite (HA) bone graft in periodontal tissue regeneration.

METHODSFour 18 months old male beagles in the experiment were treated with non-surgical periodontal therapy. At the sites of mandibular 3rd and 4th premolars at the time of dogs were treated with non-surgical periodontal therapy one week later, the teeth with the same name in the same jaw were selected to the experimental group (T group) or the control group (C group) at random. The defects in T group were filled with BME-10X collagen/HA bone graft while the defects in C group were filled with nothing. The dogs were sacrificed in twelve weeks and analyzed by histopathology.

RESULTSThe defects in T group got more tissue regeneration compared with the defects in C group. The height of new bone (NB) was (3.01 +/- 0.14) mm in T group versus (1.32 +/- 0.11) mm in C group (P < 0.05). The height of new periodontal ligament (NP) was (3.12 +/- 0.19) mm in T group versus (1.35 +/- 0.12) mm in C group (P < 0.05). The height of new cementum (NC) was (3.30 +/- 0.15) mm in T group versus (2.70 +/- 0.12) mm in C group (P > 0.05). The new tissue guided by the bone graft was the same as the normal tissue in histopathology analysis.

CONCLUSIONThe results of the study suggest that BME-10X collagen/HA bone graft is a good bone graft for periodontal tissue regeneration.

Alveolar Bone Loss ; Animals ; Bicuspid ; Bone Regeneration ; Bone Transplantation ; Collagen ; Dental Cementum ; Dogs ; Guided Tissue Regeneration, Periodontal ; Hydroxyapatites ; Male ; Mandible ; Periodontal Ligament ; Regeneration