Objective To investigate the long-term prognostic factors of acute pulmonary embolism (APE) among internal medicine inpatients with type 2 diabetes mellitus (T2DM),and establish a prediction model of long-term prognosis. Methods This study included 156 internal medicine inpatients with T2DM and APE (T2DM+APE group) admitted to internal medicine of Xinjiang 474 Hospital and The Fifth Affiliated Hospital of Xinjiang Medical University from July 2019 to June 2022. At the same time,156 inpatients with APE from the department of hematology were selected as APE group. All patients were fo llowed up for 1 year to evaluate the prognosis. Patients in T2DM+APE group were divided into good prognosis subgroup (n=108) and poor prognosis subgroup (n=48). The risk factors for poor prognosis were analyzed and a prediction model was established. Results The incidence of adverse events in T2DM+APE group was higher than that in APE group (P<0.05). Logistic regression analysis found that N-terminal precursor of B-type natriuretic peptide (NT-proBNP),cardiac troponin T (c-TnT),heart-type fatty acid binding protein (H-FABP) and simplified Pulmonary Embolism Severity Index (sPESI) score were risk factors for poor long-term prognosis of T2DM complicated with APE. The area under the curve(AUC),sensitivity and specificity of this model for predicting poor prognosis of T2DM complicated with APE were 0.938,83.3％ and 96.3％,which were higher than those of prediction with single indicator. Conclusions Patients with T2DM and APE have worse long-term prognosis than those with simple APE.The establishment of a prediction model is helpful for clinical evaluation of long-term prognosis.

Objective To investigate the long-term prognostic factors of acute pulmonary embolism (APE) among internal medicine inpatients with type 2 diabetes mellitus (T2DM),and establish a prediction model of long-term prognosis. Methods This study included 156 internal medicine inpatients with T2DM and APE (T2DM+APE group) admitted to internal medicine of Xinjiang 474 Hospital and The Fifth Affiliated Hospital of Xinjiang Medical University from July 2019 to June 2022. At the same time,156 inpatients with APE from the department of hematology were selected as APE group. All patients were fo llowed up for 1 year to evaluate the prognosis. Patients in T2DM+APE group were divided into good prognosis subgroup (n=108) and poor prognosis subgroup (n=48). The risk factors for poor prognosis were analyzed and a prediction model was established. Results The incidence of adverse events in T2DM+APE group was higher than that in APE group (P<0.05). Logistic regression analysis found that N-terminal precursor of B-type natriuretic peptide (NT-proBNP),cardiac troponin T (c-TnT),heart-type fatty acid binding protein (H-FABP) and simplified Pulmonary Embolism Severity Index (sPESI) score were risk factors for poor long-term prognosis of T2DM complicated with APE. The area under the curve(AUC),sensitivity and specificity of this model for predicting poor prognosis of T2DM complicated with APE were 0.938,83.3％ and 96.3％,which were higher than those of prediction with single indicator. Conclusions Patients with T2DM and APE have worse long-term prognosis than those with simple APE.The establishment of a prediction model is helpful for clinical evaluation of long-term prognosis.

Objective:To investigate epidemiological and clinical characteristics of botulism, and the adverse events among those received botulinum antitoxin treatment.Methods:Patients with discharge diagnosis as botulism in the Second Affiliated Hospital of Xinjiang Medical University were enrolled between 2017 and 2021. The epidemiological and clinical characteristics were evaluated. Infection and mechanical ventilation as in-hospital outcomes according to baseline characteristics were analyzed. Patients with and without the interested outcomes were compared. The adverse outcomes among those received botulinum antitoxin treatment were investigated. Those with and without the adverse outcomes were also compared.Results:Sixty-seven cases of botulism were enrolled, and most cases got sick between January and March (32/67, 47.8%); among them 62 cases were Han ethnicity (92.5%); prevalence was highest in Aksu region (15/67, 22.4%); commonly seen symptoms and signs included fatigue (58/67, 86.6%), dysphagia (48/67, 71.6%), dizziness (42/67, 62.7%), ptosis (42/67, 62.7%), blurred vision (41/67, 61.2%), and limb weakness (35/67, 52.2%). Compared with patients without in-hospital infection ( n=52), patients with in-hospital infection ( n=15) were more likely to have severe botulism (0/52 vs 5/15, χ 2=19.79, P<0.001), diplopia (16/52, 30.8% vs 11/15, χ 2=8.77, P=0.003), dysarthria (17/52, 32.7% vs 11/15, χ 2=7.91, P=0.005), consciousness disorder (1/52, 1.9% vs 4/15, χ 2=10.32, P=0.008). Compared with patients without mechanical ventilation (62/67, 92.5%), patients with mechanical ventilation (5/67, 7.5%) were more likely to have severe botulism (5/5 vs 0/62, χ 2=41.17, P<0.001), and consciousness disorder (4/5 vs 1/62, 1.6%, χ 2=29.58, P<0.001). Among 67 cases of botulism, 19 cases (28.4%) had adverse events after receiving antitoxin treatment, with an average of 6.5 days from the antitoxin treatment beginning to the adverse event onset; among the 19 cases, 18 cases (94.7%) had rash. Age, sex, and severity did not differ between the groups with ( n=19) and without adverse events ( n=48) after receiving antitoxin treatment. Conclusions:Fatigue, dysphagia, dizziness, ptosis were the most frequent symptoms and signs in the botulism in Xinjiang Uygur Autonomous Region, China. Infection was a commonly seen complication of botulism, and proactive prevention and close monitoring were needed. Adverse events after receiving antitoxin were prevalent, and might not be associated with age, sex, and severity of botulism.

Objective To investigate the clinical and laboratory features of acute promyelocytic leukemia (APL).Methotis 513 APL patients in the last two decades were retrospectively analyzed in this research.We investigated the clinical features including age,sex,abnormality of peripheral hemogram before treatment.therapeutic effect and follow-up and laboratory data such as morphology,immunology,cytogenetics and molecular biology(MICM).Results The median age of the APL patients was 33 years old and the ratio of male and female was 1.21:1.Before treatment,the median level of WBC was 4.3×109/L and the deteetion rate of abnormal promyelocyte on blood film was 85.8%;with immunophenotypie detection,the expression levels of CD117、CD34、HLA-DR、CD7、CD14 and CD19 in APL were found to be lower and the expression 1evels of CD2、CD33 and MPO higher than those in other subtypes of acute myelocytie leukemia(AML)(beth P<0.01).Specific abnormal chromosome t(15;17)was detected in 91.7%of the patients,of whom 75.9%had standard translocation of t(15;17),being the most common one and 15.8% of the patients had t(15;17)with additional abnormal chromosome.There was only 7.5%of the patients with nolnlal karyotype.However,the presence of both simple translocation and complex translocation was seldom seen.With molecular biological detection.PML/RARα fusion gene positive rate was 99.6%.In a relativelv long clinical follow-up,we found that the complete remission(CR)rate in APL patients was 84.7%.incidence of DIC was 13.4%and five-year survival rate was 30.7%.111e median count of WBC in CR group was lower than that non-remission group(P<0.01).There were no significant differences on expressions of CD34 and CD2 and changes of cytogenetics between the two groups(P>0.05).Conclusions Comprehensive evaluation of MICM could be of important significance in the diagnosis and prognosis iudgrnent for APL patients.The CR rate in these patients with high WBC eount was considerable low.