Objective:To put forward the assessment and qualification suggestions for the military flying personnel with laser corneal refractive surgery by analyzing the cases of active military flying personnel in China and reviewing the progress of refractive surgery abroad.Method:Twelve cases of laser corneal refractive surgery, including photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK) of the flying personnel treated in Air Force Medical Center, PLA from January of 2012 to December of 2021, were analyzed retrospectively, and the relevant literatures were reviewed.Results:Five cases recovered to 1.0 or better distance visual acuity by 7 d, another 3 by 1 month. Till to 2 months all 12 cases recovered to that level. The visual acuity was stable 2-3 months after operation, and the refraction tended to be stable 1 month after operation. All 12 flying personnel returned to flight duty successfully 2-6 months after operation.Conclusions:It is recommended to use surface laser corneal refractive surgery (PRK and LASEK) to correct myopia for military flying personnel and the optimum re-flight time is 2-3 months after operation in case of passing the regular aviation medical evaluation.

Objective:To put forward the assessment and qualification suggestions for the military flying personnel with laser corneal refractive surgery by analyzing the cases of active military flying personnel in China and reviewing the progress of refractive surgery abroad.Method:Twelve cases of laser corneal refractive surgery, including photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK) of the flying personnel treated in Air Force Medical Center, PLA from January of 2012 to December of 2021, were analyzed retrospectively, and the relevant literatures were reviewed.Results:Five cases recovered to 1.0 or better distance visual acuity by 7 d, another 3 by 1 month. Till to 2 months all 12 cases recovered to that level. The visual acuity was stable 2-3 months after operation, and the refraction tended to be stable 1 month after operation. All 12 flying personnel returned to flight duty successfully 2-6 months after operation.Conclusions:It is recommended to use surface laser corneal refractive surgery (PRK and LASEK) to correct myopia for military flying personnel and the optimum re-flight time is 2-3 months after operation in case of passing the regular aviation medical evaluation.

Aim To investigate the effect of salvianolate syophilized injection on brain tissue gene expression profiles in stroke of diabetic rats.Methods T1DM was induced in adult male Wistar rats by injecting streptozotocin.T1DM rats were then subjected to 90 minutes of middle cerebral artery occlusion(MCAO).The rats were randomly assigned to sham group(DM+Sham),ischemia-reperfusion group(DM+ MCAO/R),edaravone group(6 mg·kg-1,ED)and salvianolate lyophilized injection treatment group(5.25,10.5,21 mg·kg-1,SLI)with 13 rats in each group.Drugs were administered by tail vein injection 3 hours after MCAO/R,daily and lasting for 14 days.Infarct volume and gene expression in the brain tissue were detected by TTC staining and the gene chip technique.Results Compared with DM+Sham group,67 differential expressed genes were detected in the DM+MCAO/R group,among which 41 genes were up-regulated and 26 genes were down-regulated.Compared with DM+MCAO/R group,59 differential expressed genes were detected in the SLI(21 mg·kg-1)group,among which 45 genes were up-regulated and 14 genes were down-regulated.Hierarchical cluster results suggested that a number of genes were significantly changed in T1DM rats,such as Ly6i,Pax7 and Irx2.Effects of SLI on the stroke in T1DM rats were majorly related to coagulation and hemostasis system,inflammatory cytokines,oxidative stress,substance metabolism,angiogenesis and signal transduction.Conclusion Salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in type 1 diabetic rats through regulation of the coagulation and hemostasis system,inflammatory cytokines,oxidative stress,substance metabolism,angiogenesis and signal transduction.