OBJECTIVE To compare the anti-hepatitis mechanisms of Abrus pulchellus subsp. cantoniensis （Hance） Verdc. （AC） and Abrus pulchellus subsp. mollis（Hance） Verdc. （AM）. METHODS SD rats were randomly divided into blank group， AC- treated group， and AM-treated group， with each group consisting of 10 rats. The rats’ orbital venous blood was collected at 5， 15， 30 minutes， and 1， 1.5， 2， 4， 6， 8， 12 hours after gavage administration of 24 g/kg of the corresponding drug （calculated by crude drug） or water， respectively. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry technology was utilized to identify the prototype components present in the serum. The network pharmacology method was adopted to predict the anti-hepatitis active components， key targets， and signaling pathways of AC and AM. Additionally， molecular docking technology was utilized to verify the binding activity of the core active components with key targets. RESULTS A total of 35 prototype components migrating to the blood of AC and AM were identified in the serum of administered rats， among which 24 were common components. The active components in AC， such as acetylanguidine， physcion， soyasaponin A3 and soyasaponin Ⅰ， as well as those in AM， including vicenin 3， acetylanguidine，soyasaponin Ⅰ and schaftoside， all acted on key targets such as steroid receptor coactivator， phosphatidylinositol-4，5-bisphosphate 3-kinase catalytic subunit alpha， epidermal growth factor receptor （EGFR）， and protein kinase B1（Akt1）. These components modulated pathways in cancer， EGFR tyrosine kinase inhibitor resistance， and the phosphoinositide 3-kinase （PI3K） -Akt pathway， thereby exerting anti-hepatitis effects. Furthermore， the binding energies between these active components and their key targets were all less than －5 kJ/mol. CONCLUSIONS There are differences in the active components of AC and AM against hepatitis， but their mechanisms of action are similar. Both may exert their anti-hepatitis effects through pathways in cancer， EGFR tyrosine kinase inhibitor resistance， and the PI3K-Akt pathway.

Objective To investigate the end-digit preference and related factors in blood pressure measurement among inpatients.Methods A cross-sectional study was conducted on the end digits of blood pressure measurement during the admission of patients in a tertiary general hospital of shanghai in 2010,and the related factors were analyzed with the logistic regression.Results The average blood pressure in records of 2276 patients was (125 ± 14) mm Hg(1 mm Hg =0.133 kPa) in systolic and (77 ±9) mm Hg in diastolic.End-digital zero preference accounted for 1874 records (82.3％) of systolic and 1859 records (81.7％) of diastolic readings,which were significant different to the expected frequency of 20％ (P ＜ 0.001).Logistic analysis showed that admission of patients not in winter (OR =1.270,OR =1.270),patients in surgical department (OR =1.619,OR =2.045),patients with no history of hypertension (OR =1.432,OR =1.310)were the risk factors of end-digital zero preference in systolic and diastolic pressure measurement.Non-elderly patients (OR =1.288) and patients with normal heart rate(OR =1.823) were related to zero preference diastolic pressure measurement.Conclusions Blood pressure measurement of inpatient displays marked zero end-digit preference.Doctors tend to end in zero when taking blood pressure in some special types of patients.