1.Effectiveness of Insulin Deintensification and Predictors of Glycemic Control in Poorly Controlled Type 2 Diabetes Mellitus: A Retrospective Cohort Study in Malaysian Primary Care
Anuar Mohamad ; Mohd Ali &lsquo ; Imran Ab Rahaman ; Ping Foo Wong ; Mohammad Zainie Hassan ; Miguelinda Vitus Kimsin ; Hiang Ngee Chan ; Megat Muhammad Haris Megat Zainal
Journal of the ASEAN Federation of Endocrine Societies 2026;41(S1):41-
Introduction:
Insulin deintensification is an emerging strategy to reduce
hypoglycemia and treatment burden in patients on
multiple daily injection (MDI ≥3), with potential to improve
adherence and glycemic control. However, evidence in
poorly controlled type 2 diabetes mellitus (T2DM) remains
limited. This study evaluated its effectiveness and identified
factors associated with achieving adequate glycemic
control following deintensification among patients with
poorly controlled T2DM attending Malaysian primary care.
Methodology:
A retrospective cohort study was conducted among
107 T2DM patients with hemoglobin A1c (HbA1c) >9%,
attending Enhanced Diabetic Clinic at Cheras Health Clinic
between 2021 and 2025. All patients on basal-bolus insulin
(BBI) underwent deintensification. Multivariate logistic
regression was performed to identify factors associated
with achieving adequate glycemic control (HbA1c <7.5%).
Changes in HbA1c following deintensification were
assessed using paired t-tests.
Results:
Overall, 50.5% of patients achieved adequate glycemic
control. Hypoglycemia events (AOR 9.5, 95% confidence
interval [CI] 1.6–58.3; p = 0.015), MDI (AOR 9.6, 95% CI
1.4–67.1; p = 0.023) and Diabetes Medication Therapy
Adherence Clinic (DMTAC) visits (AOR 1.1, 95% CI 1.0–
1.2; p = 0.039) were significantly associated with achieving
HbA1c <7.5%. Conversely, patients transitioned from BBI
to premixed regimens were less likely to achieve HbA1c
<7.5% (AOR 0.22, 95% CI 0.05–0.93, p = 0.039). All insulin
deintensification strategies were associated with significant
HbA1c improvements with transitioned from BBI to premixed human insulin (mean difference -2.54%, 95%
CI 1.77–3.31, p <0.001, Cohen’s d = 1.09), BBI to premixed
analogue insulin (mean difference -3.38%, 95% CI 2.26–
4.49, p <0.001, Cohen’s d = 1.62), BBI to basal insulin (mean
difference -3.67%, 95% CI 1.79–5.54, p = 0.004, Cohen’s
d = 2.05).
Conclusion
Insulin deintensification is an effective strategy for
improving glycemic control in poorly controlled T2DM.
These findings highlight the importance of deintensification
with careful consideration of hypoglycemia, MDI-related
treatment burden, and patient engagement through regular
DMTAC visits, which are integral to achieving optimal
outcomes and support a personalized approach to diabetes
management in primary care.
Diabetes Mellitus, Type 2
;
Glycemic Control
;
Retrospective Studies
;
Primary Health Care
;
Insulins
3.Malaysian clinical practice guidelines for management of diabetic foot: A synopsis for the primary care physician
Tharumaraja Thiruselvam ; Aminudin Che Ahmad ; Wong Ping Foo ; Afiza Hanun Ahmad@Hamid ; Mohd Idham Hasan ; Mohd Yazid Bajuri ; Gurmeet Singh s/o Sewa Singh ; Vijiya Mala Valayatham ; Siti Norzalilah Abdul Majid ; Hafizan Mohd Tajri ; Masfiza Abdul Hamid ; Ainol Haniza Kherul Anuwar ; Mohd Aminuddin Mohd Yusof
Malaysian Family Physician 2021;16(1):103-113
Diabetic foot requires careful attention and coordinated management by a dedicated team. Screening, prevention, adequate assessment, and appropriate referral are crucial to prevent complications. Multimodal treatment and rehabilitation are recommended to ensure a better quality of life and reduction of amputation rate in people with diabetic foot.
4.Barriers to implementing a national health screening program for men in Malaysia: An online survey of healthcare providers
Chirk Jenn Ng ; Chin Hai Teo ; Kar Mun Ang ; Yong Leng Kok ; Khalid Ashraf ; Hui Ling Leong ; Sri Wahyu Taher ; Zakiah Mohd Said ; Zainal Fitri Zakaria ; Ping Foo Wong ; Chee Peng Hor ; Teng Aik Ong ; Husni Hussain ; V Paranthaman P Vengadasalam ; Chiu Wan Ng ; Kavitha Agamutu ; Mohamad Aznuddin Abd Razak
Malaysian Family Physician 2020;15(1):6-14
Introduction: This study aimed to determine the views and practices of healthcare providers and
barriers they encountered when implementing the national health screening program for men in a
public primary care setting in Malaysia.
Methods: An online survey was conducted among healthcare providers across public health clinics in
Malaysia. All family medicine specialists, medical officers, nurses and assistant medical officers involved in the screening program for adult men were invited to answer a 51-item questionnaire via email or WhatsApp. The questionnaire comprised five sections: participants’ socio-demographic information, current screening practices, barriers and facilitators to using the screening tool, and views on the content and format of the screening tool.
Results: A total of 231 healthcare providers from 129 health clinics participated in this survey.
Among them, 37.44% perceived the implementation of the screening program as a “top-down
decision.” Although 37.44% found the screening tool for adult men “useful,” some felt that it was
“time consuming” to fill out (38.2%) and “lengthy” (28.3%). In addition, ‘adult men refuse to answer’
(24.1%) was cited as the most common patient-related barrier.
Conclusions: This study provided useful insights into the challenges encountered by the public
healthcare providers when implementing a national screening program for men. The screening tool for
adult men should be revised to make it more user-friendly. Further studies should explore the reasons
why men were reluctant to participate in health screenings, thus enhancing the implementation of
screening programs in primary care.
5.Management of Atopic Eczema in primary care
Ainol Haniza Kherul Anuwar ; Azura Mohd Affandi ; Ch&rsquo ; ng Chin Chwen ; Dawn Ambrose ; Heah Sheau Szu ; Khor Yek Huan ; Lalitha Pillay a/p B. Gopinathan ; Leow Wooi Leong ; Mohd. Aminuddin Mohd. Yusof ; Noor Zalmy Azizan ; Sabeera Begum ; Siti Shafatun Mohsin ; Tan Wooi Chiang ; Tarita Taib ; Wong Ping Foo ; Zaridah Zainuri ; Siti Mariam Tukimin
Malaysian Family Physician 2020;15(1):39-43
Introduction: Atopic eczema (AE) is a common infammatory skin dermatosis that is increasing
in prevalence. However, it can present in various clinical presentations, which leads to challenges
in the diagnosis and treatment of the condition, especially in a primary care setting. Te Clinical
Practice Guidelines on the Management of Atopic Eczema was developed by a multidisciplinary
development group and approved by the Ministry of Health Malaysia in 2018. It covers the aspects
of diagnosis, severity assessment, treatment, and referral.


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