Background: Total knee replacement arthroplasty (TKA) is an essential surgical treatment method performed when the cartilage surfaces of the knee joint undergo irreversible changes due to aging, trauma, genetics, or lifestyle factors. In our country, approximately 2.500 knee replacement surgeries are performed annually. Aim: To investigate the Lysholm scores of patients who underwent total knee replacement arthroplasty and the factors influencing these scores. Materials and Methods: This study was conducted using a retrospective cohort study design. The research was carried out at the First Central Hospital of the country, involving 186 patients who visited the Department of Joint Center from January 2007 to May 2023. Participants provided demographic data, information on comorbidities, alcohol and tobacco use, physical activity, and lifestyle factors through a 56-question survey, divided into two groups. The stability and function of the knee joint were assessed using the Lysholm assessment. A score of 95-100 indicated excellent, 84-94 good, 65-83 moderate, and less than 65 poor. Statistical analysis of the results was performed using SPSS version 26.0. Results: Out of 185 participants, the mean age was 71.83±7.83 years, with 18.9% (n=35) males and 81.1% (n=150) females. The demographic factors such as gender, age group, BMI, and years after surgery were significantly associated with the Lysholm score (p=0.001). Logistic regression analysis identified that age (OR, 2.014; 95% CI, 1.620-1.659; p=0.001), excess weight (OR, 1.328; p=0.001; 95% CI, 0.469-3.765), and years after surgery (OR, 1.194; 95% CI, 0.533- 2.676; p=0.037) were factors influencing the scores Conclusion 037) were factors influencing the scores. Conclusion: The number of years after total knee replacement arthroplasty and patient age significantly affected Lysholm evaluation scores