Background: Respiratory diseases remain among the top five leading causes of morbidity, with an incidence rate of 788.4 cases per 10,000 population in 2021. Among these, acute bronchitis accounts for 9.3%. According to international clinical guidelines for the diagnosis and treatment of adult acute bronchitis, symptoms usually resolve spontaneously within 1–3 weeks, but they considerably reduce the patient’s quality of life. Therefore, Colsaurin syrup, a new natural formulation with analgesic and anti-inflammatory effects, was clinically investigated to assess its efficacy and safety. The introduction of this domestically produced herbal medicine into clinical practice is expected to have both medical and socioeconomic significance by expanding the range of national pharmaceutical products. Aim: To evaluate the effect of Colsaurin syrup on the quality of life in adults diagnosed with acute bronchitis. Materials and Methods: This study was a randomized, double-blind, placebo-controlled clinical trial conducted among inpatients at Songinokhairkhan District General Hospital, Ulaanbaatar. Adult patients diagnosed with acute bronchitis (J20) who met the inclusion criteria and provided informed consent were enrolled. Participants were randomly assigned to either the Colsaurin or placebo group. Result: In the Bronchitis Severity Score (BBS) assessment, baseline mean scores indicated severe disease: 10.88±2.47 in the Colsaurin group and 10.67±2.16 in the placebo group. After treatment, scores decreased significantly to 3.50±1.41 (p<0.001) in the Colsaurin group and 5.00±2.24 (p=0.006) in the placebo group, indicating greater improvement in the Colsaurin-treated patients. In the Visual Analog Scale (VAS) assessment, the mean pre-treatment score for both groups was 7, corresponding to frequent cough, which decreased to 2 after treatment (p<0.05), representing a 28% reduction in coughing discomfort. In the Cough and Sputum Assessment Questionnaire (CASA-Q), the Colsaurin group showed a 3.25-point reduction after treatment, indicating a significant decrease in cough frequency and triggering factors (p<0.05). Conclusion 1. In patients diagnosed with acute bronchitis (J20), treatment with Colsaurin syrup reduced disease severity by 30% and alleviated cough-related discomfort by 28% compared to baseline. 2. Moreover, patients reported improved sleep quality and work capacity, reflecting an overall enhancement in quality of life. 3. No adverse effects were observed in the Colsaurin treatment group.

The biologically active food supplement products were produced in the form natural raw materials for powder, tablets, pellets, capsule, juice and extract preparation. Osteoporosis disease is increasing among the population of the world in recent years. Therefore, calcium supplement is used more often for prevention of this disease. Osteoporosis is now widely recognized as a public health problem since this disease, which increases bone fragility and thereby the risk of fractures, is associated with high mortality, morbidity and medical expenses throughout the world. We obtained new “Eghomon” supplement which reduces osteoporosis. We determined by quantitative analysis, the calcium ion and mineral composition is a crystal structure in this supplement. In the study, we used titrimetric, X-ray fl uorescence and X-ray diffractometer spectroscopy methods. The following mineral elements such as, Ca, P, Mg, Fe, Mn, Al, Na, K, Si, Ti were contained in the Eghomon supplement. Additionally, we determined the concentration of calcium ion 22.9 percent in the supplement. INTRODUCTION Mineral ions such as calcium, phosphorus, magnesium, copper, zinc, etc.., play a tremendous role in the metabolic processes of the human body, including tissue, fl uid, and bone. In each are they function to promote and maintain normal body function with a wide range of activities including assisting in body hydration, enzyme activation, maintenance of pH, as cofactors in blood coagulation, controlling neuromuscular excitability, as well as promoting the stability of bones and teeth, and many other functions. Calcium is the most abundant mineral in the human body, most of which (98%) is present in the skeleton. The concentration of calcium ion in the blood is very important for the development and preservation of strong bones and teeth. Absorption of too much calcium in the blood may lead to the leaching of calcium from the bones and teeth. The absorption of calcium is controlled, in part, by vitamin D. Growing children in particular need an ample supply of calcium for the development of strong bones. Milk, which is a good natural source of calcium and which is consumed primarily by children, is usually fortifi ed with vitamin D to promote calcium absorption. Similarly, outdoor recess for elementary school children is mandated by law in many states because exposure to sunshine allows the body to synthesize vitamin D. In later adulthood, particularly among women, the level of calcium in the blood may decrease to the point where calcium is removed from the bones and teeth to replace the blood calcium, making the bones and teeth much weaker and more susceptible to fracture. This condition is known as osteoporosis and can become very serious, causing shrinking if the skeleton and severe arthritis. For this reason, calcium supplements are often prescribed in an effort to maintain the proper concentration of calciumion in the blood. Although the results are not yet conclusive, recent reports indicate 100mg of calcium ion, taken orally on a daily basis, may serve to prevent osteoporosis. Typically, such calcium supplements consist of calcium carbonate, calcium citrate and calcium lactate. MATERIALS AND METHODS We conducted used in the study of natural biologically active food supplements Eghomon. The researchers invented new Eghomon supplement in the institute of traditional medicine and technology of Mongolia. Eghomon is composed from horse bones and eggshells. It is a calcium preparation.

Background: Gishuun-6, Sugmel-7, Shijid-6, Lishi-6, Harutsa- 5, Sorool-4, Sugmel-3 and Zandan-3 are used for treatment of gastric ailments, urological disorders and grippe. Various medicinal plants such as Amomum Kravanh pire ex Gagnep, Terminalia chebula, Zingiber officinale /Willd/ Rosc, Rheum undulatum L./, Polygonium bistorta L, Eugenia caryohyllata Trunb, and Choerospondia axillaris (Roxb) are contained in these drugs. Biologically active substances including alkaloid, flavonoid, saponin, organic acids and vitamins have been determined. Phenolic compounds are believed to reduce low-density lipoprotein and have some favorable effects on heart diseases and cancer. Objectives: Phenol contents in above mentioned traditional drugs and microbial growth within the drugs were determined. Methods: Extraction of compounds were performed by using high polarity organic absorbents and analyzed by thin layer chromatography. Total content of phenol compounds was determined by Folin-Ciocalteu method. Bacterial and fungus contamination was examined in accordance with MNS 5193, 5194, 5188, 5189, 5190: 2002 standards. Results and conclusions: Phenolic compounds were determined in all drugs. Bacterial contamination of the drugs was within the range of approved level. Table 1. Total phenol contents in water extracts of the drugs (10-2 and 10-3 dilution) and count of bacteria on tryptic soy agar and Sabouraud’s agar

Background: Wound healing mechanisms still unclear. Wounds are physical injuries that result in an opening or breaking of the skin. Proper healing of wounds is essential for the restoration of disrupted anatomical continuity and disturbed functional status of the skin. This is a product of the integrated response of several cell types to injury. Wound healing is a complex process that results in the contraction and closure of the wound and restoration of a functional barrier.Goal: The purpose of this study was to determine burn wound healing activity of Calvacin. Materials and Methods:We used in study as colored reaction thin layer chromatography (TLC) and UV-spectrophotometer methods to determine active compounds in the three component drug "Calvacin".In research were inducted 20 healthy white mice and 40 rats. Investigation was based and implemented at scientific research laboratory of Traditional Medical Science Technology and Production Corporation and Institute of Veterinary medicine of pathological laboratory. The study protocol was approved by the Ethics Committee of the Ministry of Health.Results:Results of the phytochemical investigations showed that contained in the new drug "Calvacin" determined the presence of bioactive substances such as flavonoids, saponin, tannin, curcuminoids, organic acids and minerals. Substance was absorbed 25.7% in 40 grade ethanol, 27.1% in 70 grade, 22.2% in 96 grade and 19.6% in sterile water. We was established quality quantities of Calvacin in the drug amount summary flavonoids 1% and determined by UV spectrophotometer method. Proceeding from the absorption maximum of the substances analyzed the wave length of detection was determined as 370nm. In the result of mineral study of the "Calvacin", Ca^2.3%, P-6.17%, K-5.58%Burn wound healing time is control group 35±0.1 days, on 26±0.1 day animals of Calvacin group, but animals of Vishinski's ointment group 33±0.1 (p<0.05).Conclusions:1. The phytochemical investigations contained in the "Calvacin" drug determined the presence of bioactive substances such as flavonoids, saponin, tannin, curcuminoids, organic acids and minerals.2. Calvacin preparation has less toxic and significantly stimulate experimentally induced wound contract.