1.Whole-Body Phase Angle as a Marker of Cellular Health in a Workplace Lifestyle Intervention
Mohd Nahar Azmi Bin Mohamed ; Nurul Zfarina Binti Mohd Zaid
Journal of the ASEAN Federation of Endocrine Societies 2026;41(S1):57-
Introduction:
Phase angle (PhA) derived from bioelectrical impedance
analysis reflects cellular integrity and has emerged as a
potential marker of metabolic health. Its role in detecting
early physiological changes during lifestyle intervention
remains underexplored in workplace obesity programmes.
Methodology:
This longitudinal study included 30 adults with complete
paired measurements enrolled in a 12-month workplace
lifestyle programme. Body composition was assessed
using multifrequency bioelectrical impedance analysis.
Measurements included whole-body PhA, body cell mass
(BCM), skeletal muscle index (SMI), and extracellular
water to total body water ratio. Paired comparisons and
correlation analyses were performed.
Results:
Mean PhA increased modestly from 5.59 ± 0.70° to 5.67 ±
0.69°, although this did not reach statistical significance (p
= 0.17). Changes in PhA were not significantly associated
with changes in BCM (r = −0.03, p = 0.89). However, baseline
PhA demonstrated a moderate positive association with
SMI (r ≈ 0.51, p <0.01), suggesting a link between cellular
integrity and muscle status. Individual trajectories revealed
heterogeneous responses despite minimal weight change.
Conclusion
Whole-body phase angle provides insight into cellular
health beyond conventional anthropometric measures.
While short-term changes were modest, PhA may serve
as a clinically useful adjunct for monitoring physiological
response in obesity management programmes.
Workplace
2.Beyond Body Weight: Body Composition and Cellular Health in a Workplace Obesity Intervention Programme
Mohd Nahar Azmi Bin Mohamed ; Nurul Zfarina Binti Mohd Zaid
Journal of the ASEAN Federation of Endocrine Societies 2026;41(S1):58-
Introduction:
Obesity is a chronic disease characterized by complex
alterations in body composition and metabolic health. Traditional reliance on body weight may overlook important
physiological adaptations during lifestyle intervention.
Methodology:
A cohort of 99 participants at programme entry underwent
body composition assessment using bioelectrical impedance analysis. Parameters included percent body fat (PBF),
visceral fat area (VFA), skeletal muscle index (SMI), and
phase angle (PhA). Correlation analyses were performed to
explore relationships between adiposity, muscle mass, and
cellular health.
Results:
Participants demonstrated elevated adiposity (PBF 38.9 ±
8.9%; VFA 142.9 ± 56.1 cm²). PhA was inversely associated
with VFA (r ≈ −0.23, p <0.05) and positively associated with
SMI (r ≈ 0.49, p <0.001). Notably, a subset of overweight
individuals exhibited relatively preserved PhA, indicating
heterogeneity in metabolic health despite similar adiposity
levels.
Conclusion
Body composition and PhA provide complementary
insights into metabolic health beyond body weight. These
findings support the role of bioimpedance-derived parameters in identifying metabolic heterogeneity and guiding
personalized obesity management.
Body Composition
;
Body Weight
;
Workplace
;
Obesity


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