OCCUPATIONAL STRESS, COPING STRATEGIES, AND QUALITY OF LIFE AMONG NURSES IN ABHA CITY Background: The nursing profession is inherently stressful, and nurses in Abha City face unique challenges due to rapid population growth and evolving healthcare needs. Objective: The purpose of the present study is to identify the correlation between “Occupational stress, coping strategies and quality of life” among nurses in Abha city. Method: The present study utilized a cross-sectional, descriptive survey, and correlational research design. A convenience sampling throughout an online questionnaire was used to recruit 411 nurses from three hospitals in Abha city, and data was collected using three validated instruments: The Expanded Nursing Stress Scale, the Brief Cope Scale, and the World Health Organization-Quality of Life Scale. SPSS version 26 was used for data analysis, including descriptive statistics, independent samples t-test, ANOVA, and Pearson’s correlation coefficient. Results: Findings revealed a moderate level of occupational stress (mean score 2.31 ± 0.56 on the ENSS-59 scale), with the main sources being dealing with patients and their families (2.35 ± 0.65), uncertainty concerning treatment (2.33 ± 0.66), and discrimination (2.32 ± 0.88). Nurses employed coping strategies such as planning (2.49 ± 0.75), religion (2.47 ± 0.72), and substance use (2.45 ± 0.77), while the least adopted strategies were self-blame (2.40 ± 0.71), self-distraction (2.37 ± 0.73), and behavioral disengagement (2.32 ± 0.73). Significant associations were found between sources of occupational stress and coping strategies, such as death and dying stress source correlating with self-distraction (r=0.202), use of instrumental support (r=0.111), positive reframing (r=0.154), humor (r=0.111), religion (r=0.142), and self-blame (r=0.141). Conflict with peers as a stress source was significantly correlated with self-distraction (r=0.157), denial (r=0.158), substance use (r=0.183), use of instrumental support (r=0.130), behavioral disengagement (r=0.106), venting (r=0.121), humor (r=0.203), religion (r=0.106), and self-blame (r=0.152). A significantly negative association between occupational stress and quality of life was also identified (r=-0.451). Conclusion: Significant correlation were found between sources of occupational stress and coping strategies. The study also demonstrated a significant negative association between occupational stress and quality of life, emphasizing the need for interventions to reduce occupational stress and enhance nurses’ well-being. ASEAN Journal of Psychiatry, Vol. 25 (2) February, 2024; 1-14.