Background: The development of a country is often measured by the state of human development, especially maternal and child health indicators. In Mongolia, public health policies targeting the prevention of non-communicable diseases related to lifestyle and physical development among adolescents are critically needed. However, there is a lack of regional studies on adolescent health, particularly in rural areas. Aim: To study certain physical development indicators among adolescents in Bulgan province. Materials and Methods: This analytical study was conducted in 2022 involving 781 twelve-year-old children. Data were collected from parents and processed using Stata 17.0. Percentages were calculated for qualitative data, and Chi-square and Fisher’s exact tests were used for statistical analysis. Where statistically significant, multinomial logistic regression analysis was applied to identify risk factors affecting physical development. Results: 52.88% of the participants were boys,92.45% lived in traditional or private hous12.04% of the children showed growth retardation. 49.68% were overweight.70.94% were classified as overweight or obese based on their Body Mass Index (BMI).Weak muscle strength (1.66%), flexibility (2.05%), endurance (1.66%), and agility (1.92%) were observed. Boys were more likely to experience height retardation but had stronger muscle strength.Girls showed a higher prevalence of being overweight.Children living in the provincial center had higher height and BMI, while those in soum centers demonstrated statistically significant strength in muscle power, flexibility, and endurance. Conclusion 1. Among the study participants, 70.94% of children were overweight or obese. 2. 1.66% of the study participants had weak muscle strength, 2.05% had weak flexibility, 1.66% had weak endurance, and 1.92% had weak speed and agility. 3. The use of mobile phones, parental involvement, inactivity, lack of sports, and lack of horse riding have negative effects on physical development.

Background: Cardiovascular diseases (CVDs) is a third leading cause of non-communicable diseases and a leading cause of mortality in Mongolia. Among these, acute myocardial infarction (AMI), a complication of coronary artery disease (CAD), is a leading cause of cardiovascular mortality. In patients with AMI, both epicardial artery blood flow, observed through coronary angiography, and coronary microcirculatory dysfunction (CMD) play critical roles in the disease’s pathophysiology. Recent advancements have introduced artificial intelligence (AI)-based softwares which are capable of analyzing coronary blood flow from coronary angiography images. The AI based softwares can assess not only epicardial blood flow but also CMD in recent studies. In this review, we discussed the role of CMD in pathophysiology of AMI, diagnostic approaches, the application of AI-based technologies, their clinical significance, and future directions. Aim: This review aims to explore the pathophysiological relationship of coronary microcirculatory dysfunction (CMD) in the context of acute myocardial infarction (AMI), diagnostic methodologies, the application of artificial intelligence (AI)-based technologies, and their clinical significance. Hypotheses: 1. AI-based software allows for highly accurate assessment of coronary microcirculation during AMI. 2. CMD during AMI is associated with structural and functional changes in the heart. 3. CMD during AMI is related to disease prognosis and patient outcomes. Methodology:: This narrative review was compiled using a systematic and logical approach, based on publicly available recent clinical and biomedical research literature addressing the above hypotheses. Conclusion In recent years, AI-based image processing software has been developed to analyze angiographic images obtained during percutaneous coronary intervention (PCI) and treatment procedures. These tools show significant promise for early detection and improved diagnosis of CMD during AMI, as well as for better assessment of short- and long-term patient risk.

Background: A particular appealing problem in the medical field of our country is non-communicable diseases, which are derived from child development and lifestyle, prevention and the decision was approved on being used the maternal and child health handbook in order to be promptly needed the publicly covered medical policy toward those. Several researchers have noted that in developed countries longitudinal studies are used for checking and controlling in wide range of epidemic diseases and health issues for maternal and child, pregnancy and postpartum period as well as this method is directed to be found out multiple information and knowledge. Not having studied enough how well current situations for postpartum period and maternal and child health in our countryside is become the foundation for our research work. Moreover, it needs to be found out what kind of factors, which are effected on children who were born to the year of 2010 in Bulgan province, where it started using the first and only maternal and child health handbook (so called a pink handbook) in Mongolia, health issues. Also, the foundation of this study was to be needed to focus on our attention to which level of the medical field in order to improve those generations health issues are improved, Aim: to evaluate of a written usage of the maternal and child health handbook, to define its needs, to advertise its results to the public. Materials and Methods: The study is made with a cohort design of an analytical method based on collected information in 2013, of mothers and children, who are in need, giving birth and being born in 2010 and the results were made on Stata 17 program. The answers were taken with the base study of 2013 from 1015 original case sources within study groups in needs, and collected information covered with current and actual local situation, as well as to be involved in mothers and children, who gave birth and were born in 17 sums’ health institutions of Bulgan province. Results: Participants age range and educational backgrounds; 70.34 % of mothers were between 20-34 ages, 29.36% of mothers were 35 and over ages. 1.51% of uneducated mothers, 39.06 % of high school graduates, 49.1% of permanent residents, 45.38 % of temporary or nomadic or the smallest units residents of administration, 92.08% of married, 39.88% of families are consisted in members over 5, 52.12% of boys with average weights of 3389.8 grams during the period of being born, 9.86% of heavy pregnancy or heavy weight fetuses, 4.14% of light weight fetuses or light weight infants. Plus, the study was defined the mothers educational background to be great and helpful strength to use and record and to define the usages of the maternal and child health handbook, which was given and thoroughly explained to the mothers at the beginning. The leading diseases and their reasons were among three-year aged children, who were covered and recorded with 173 severe burnt, 42 falling injuries from something, 22 being hit and 19 were bitten by animals. In this study there were 17.83% of participants without the maternal and child health handbooks (pink handbooks), 81.77% of participants carried their pink handbooks with them when they went to the health facilities, 68.47% of them, who were gotten explanations from the doctors, when the pink handbooks were opened by, 71.72% of participants answered the pink handbooks to be needed. The results of this study have indicated that 71.72% of mothers, who used it at first time, answered the maternal and child health handbooks were very important and handy for understanding to check and observe for mothers and children’s development and growth. Conclusion It was the leading reason, which was predominantly recorded with cases of burning, falling injuries, hit and bitten by animals among three-year of children, who were participated in this study. There were high amounts of respiratory diseases and diarrheas among toddlers. 71.72% of participants considered that the maternal and child health handbooks were important.

Background: In recent years, stroke has remained one of the leading causes of morbidity and mortality worldwide. Globally, the incidence among adults ranges from 134.9 to 336.3 cases per 100,000 population annually, with mortality rates between 36.7 and 136.7 per 100,000. In Mongolian traditional medicine, stroke prevention is not only related to diet and lifestyle but also depends on an individual’s unique bodily constitution, age, strength, and life habits. Since people differ physiologically, the diseases arising from the four causative conditions manifest differently. Therefore, this study was conducted to explore the relationship between an individual’s constitutional type and stroke risk factors, aiming to contribute to stroke prevention. Aim: To study the relationship between individual constitutional types in Mongolian traditional medicine and stroke risk factors, specifically hypertension and dyslipidemia. Materials and Methods: A total of 2,086 participants were included from the Departments of Cardiology, Neurology, and Ultrasonography of the affiliated hospital of the Inner Mongolia National University. Data were collected through questionnaires, assessment of constitutional type, blood pressure measurement, and blood lipid analysis. Statistical processing was performed using SPSS 18.0 software. Chi-square (χ²), ANOVA tests, multivariate logistic regression, and correspondence analysis were used, with p<0.05 considered statistically significant. Results: Among the participants, those with the “Khurmal” (Hormal) and “Badgan-Khi” (Phlegm-Wind) constitutions accounted for the highest proportions (34.3% and 26.7%, respectively), showing a statistically significant association with stroke risk factors (p<0.05). In terms of the relationship between constitution and blood pressure, individuals with the Badgan-Khi type had a higher risk, and a statistically significant association was found between blood pressure, risk classification, and the Badgan-Khi and Khormal types (p<0.05). Regarding constitution and blood lipid levels, the proportions in the stroke population were: indeterminate lipid ratio (58.3%), dyslipidemia (33.3%), and normal blood lipids (8.3%). A statistically significant relationship was observed between blood lipid levels, risk classification, and the Khi-Shar and Badgan-Khi constitutions (p<0.05). Conclusion Stroke risk factors such as hypertension and dyslipidemia are associated with an individual’s body constitutional type. The study confirmed that individuals with a Khi-dominant constitution tend to have higher sympathetic nervous system activity, blood pressure, and vascular reactivity, providing a biological basis for increased stroke risk. For Badgan-dominant individuals, metabolic disturbances and lipid accumulation were identified as contributors to elevated stroke risk.

Background: The continuous annual increase in the prevalence of diabetes mellitus (DM) poses significant challenges not only within our nation but also globally in the control and management of tuberculosis. Aim: This study aimed to determine the incidence of pulmonary tuberculosis among individuals with type 2 diabetes mellitus (T2DM) residing in six central districts of Ulaanbaatar and to investigate associated factors. Materials and Methods: A cross-sectional study design was employed. Participants aged 18 years and older diagnosed with T2DM and receiving care at endocrinology clinics in six central districts of Ulaanbaatar were selected using systematic random sampling. Presumptive TB cases were identified through a structured questionnaire and chest X-ray. Sputum specimens were collected and subjected to smear microscopy and Xpert MTB/RIF assay for tuberculosis detection. Cases confirmed by laboratory diagnosis, currently undergoing tuberculosis treatment and previously treated cases as per questionnaire data were classified as tuberculosis cases, and prevalence was calculated. Results: A total of 1,644 individuals with T2DM were enrolled in the study, of whom 836 (50.9%) were female, with a mean age of 58 years (range 19–89). The overall prevalence of presumptive TB cases was 10.5% (n=172; 95% CI, 9.0–12.0). Among 112 suspected cases from whom sputum samples were obtained, 10 (8.9%; 95% CI, 4.9–15.7) were laboratory-confirmed for M.tuberculosis. Notably, 7.2% (6 cases; 95% CI, 3.4–14.9) of asymptomatic individuals with abnormal X-ray findings were diagnosed with tuberculosis. According to questionnaire responses, 9 participants (0.5%; 95% CI, 0.3–1.0) were undergoing tuberculosis treatment, and 53 (3.2%; 95% CI, 2.5–4.2) reported a previously treated TB cases. The overall prevalence of tuberculosis among individuals with diabetes was 4.4% (n=72; 95% CI, 3.5–5.5). Stratification by age and sex revealed a significantly higher prevalence among males (5.9%; n=48; 95% CI, 4.5–7.8) compared to females (2.9%; 95% CI, 1.2–4.2) (p=0.002), indicating a twofold increased risk of tuberculosis in males. Although no statistically significant differences in tuberculosis prevalence were observed across age groups (p>0.05), a declining trend in prevalence with older age was noted. Conclusion The prevalence of tuberculosis among individuals with type 2 diabetes was 4.4% (n=72; 95% CI, 3.5–5.5), with a significantly higher rate in males (p=0.002) and a decreasing trend with increasing age. Among asymptomatic individuals exhibiting radiographic abnormalities, 7.2% were confirmed to have tuberculosis via laboratory testing

Background: Obesity and metabolic disorders are significant contributors to hypertension and cardiovascular disease (CVD). While body mass index (BMI) and waist circumference are known to be associated with systolic blood pressure (SBP), the interplay between adiposity, glucose levels, triglycerides, and SBP is not fully understood. This study aims to investigate the relationships between BMI, waist circumference, glucose, triglycerides, and SBP in a large population-based cohort. Methods: A cross-sectional analysis was conducted on [insert total number] participants with complete data on BMI, waist circumference, blood pressure, glucose, and triglycerides. Descriptive statistics, ANOVA, Pearson correlations, mediation analysis, and multiple regression were used to explore the associations between variables. The moderation effect of glucose on the BMI-SBP relationship was examined using an interaction term in the regression model. Results: The mean age of the study population was 44.3 ± 15.2 years. The mean BMI was 26.7 ± 4.9 kg/m², and 22.7% of participants were classified as obese. Central obesity, measured by waist circumference, was prevalent in 55.9% of the population. BMI, waist circumference, glucose, and triglycerides were significantly associated with SBP (p < 0.0001). Mediation analysis showed that waist circumference partially mediated the effect of BMI on SBP. The interaction term for BMI and glucose was significant (β = 0.32, p < 0.05), indicating that glucose levels moderated the relationship between BMI and SBP, with higher glucose levels amplifying the hypertensive effect of BMI. Conclusion This study highlights the complex interplay between BMI, waist circumference, glucose, triglycerides, and SBP. Waist circumference partially mediates the effect of BMI on SBP, and glucose levels moderate this relationship, amplifying the impact of obesity on blood pressure.

In this study, the anti-inflammatory activity and ER stress modulation of the hexane fraction from Peucedanum insolens Kitag. root was investigated. The anti-inflammatory activity was evaluated by measuring nitric oxide inhibition and analyzing iNOS and COX-2 expression in LPS-treated RAW 264.7 macrophages using Western blot. The hexane fraction’s effect on ER stress was assessed by monitoring ATF6α transcriptional activity in the stable recombinant HLR-GV-hATF6α (333) cell line. Additionally, the expression levels of ER stress-related proteins, including eIF2α, p-eIF2α, GRP78, and CHOP, were analyzed by western blot in HeLa cells. Our results demonstrated that the hexane fraction strongly inhibited nitric oxide production and the expression of iNOS and COX-2 in LPS-treated RAW 264.7 cells. It also significantly reduced ATF6α transcriptional activation induced by thapsigargin or tunicamycin. In HeLa cells, the hexane fraction inhibited the expression of ER stress-related proteins GRP78 and CHOP induced by thapsigargin. Although the hexane fraction alone did not affect GRP78, CHOP and eIF2α levels, it enhanced eIF2α phosphorylation in a concentrationdependent manner. Co-treatment with the hexane extract and thapsigargin prevented both CHOP and GRP78 expressions and eIF2α phosphorylation. Taken together, our results suggest that the anti-inflammatory potency of the hexane-fraction of P. insolens might be related to its potential to modulate ER stress. To find out more detailed integrated actions of the hexanefraction of P. insolens against ER stress-induced inflammation signalling and to identify bioactive compound(s) associated with ERSR-related inflammation, further studies are required using a single cell type, such as RAW 264.7 or HeLa cells.

Introduction: Among the endocrine, nutritional, and metabolic disease and thyroid disorders occupy a significant place. According to the World Health Organization, 8-18% of the world’s population suffer from thyroid disorders. In our country, no research on the prevalence of the disorders has been conducted before, and this research methodology was discussed by the Scientific committee of the National Center for Public Health and was approved by resolution No.156 of the Ethics Committee of the Ministry of Health on 2020. Materials and Methods: In order to determine the prevalence of thyroid disease in the country, we collected the actual number of thyroid disorders registered in 9 districts of the capital city and 330 soums of 21 aimags for a total of 10 years from 2011 to 2020. The prevalence of thyroid disorders was mapped using Arc view and GIS software. Results Endocrine, nutritional and metabolic disease account for 2.3% of all outpatient cases. Endocrine, nutritional, and metabolic disease accounted for an average of 168.3 per 10000 population over the past 10 years, and thyroid disorders accounted for 45 or 26.7% of endocrine, nutritional, and metabolic diseases. Thyroid disorders are highest in people aged 40-49 years.
Thyroid toxicity is the most common type of thyroid disease in Mongolia, accounting for 56.2%, with an average of 17.2 per 10000 population in 2011-2020. However, iodine deficiency-related thyroid disease accounts for 5.5% of all thyroid disorders, with an average of 2.5 per 10000 population in 2011-2020. In 2011, it decreased by 2.2 per 10000 population, and by 2020, it decreased by 0.2 per thousand to 2.0, but in the last 5 years, it has increased by an average of 2.4 per 10,000 population, and in the last 5 years it has increased by 0.2 per thousand, or 2.6 per 10,000 population. Morbidity is high in the Khangai and Central regions.

Rationale: Carbon monoxide (CO) is a colorless, odorless gas produced by carbon-containing substances, most commonly incomplete fuel and biomass combustion. Carbon monoxide deprives the human body of oxygen, leads to severe poisoning and death. In 2017, there were 137 new cases of carbon monoxide poisoning per 1,000,000 people worldwide, and 4.6 deaths per 1,000,000. The global incidence of carbon monoxide poisoning has remained steady over the previous 25 years, while mortality has decreased by 36-40%. Every year in Mongolia, 700-840 persons are hospitalized for carbon monoxide poisoning. Also, there has been a lack of study into the prevalence and causes of carbon monoxide poisoning and death. Goal: Study the dynamics of morbidity and mortality cases caused by carbon monoxide poisoning in Mongolia. Objectives:
To analyze the carbon monoxide poisoning morbidity recorded in Mongolia between 2016-2020.
To analyze the carbon monoxide poisoning mortality reported in Mongolia between 2016-2020. Material and Methods: The survey was conducted utilizing data from outpatient and inpatient poisoning and deaths reported in 2016-2020 with the goal of studying carbon monoxide poisoning and mortality in Mongolia. Workplace exposure poisoning was excluded from quantitative data on carbon monoxide poisoning (fires, suicidal, accidental and domestic explosions, accidents, external effects).The statistics analysis was performed using 23 versions of the SPSS program, to estimate a distribution of new cases and fatalities per 10,000 population depended on age, sex, average number of hospital days, and standard error. ArcGIS version 10.8 was used to map the locations. Results: Acute carbon monoxide poisoning. Carbon monoxide poisoning was 0.01-0.31 cases per 10,000 population during 2016 and 2018. Between 2019 and 2020, it increased to 1.5-1.9 cases per 10,000 population, with up to 37% of those admitted to hospitals. In the last five years, carbon monoxiderelated deaths have been reported in 0.1-0.3 cases per 10,000 population. The amount of hours firing of the households increases every year in September, when the colder season begins. Incidences of death and intentional poisoning were reported in Arkhangai, Uvurkhangai, Khuvsgulaimags, and Ulaanbaatar. The average age of poisoning patients admitted to the hospital was 33 ± 19.5 years old (minimum 2 months, maximum 81). In terms of gender, women registered for 58.4 (734) percent of all cases. The average number of days spent in the hospital was 3.4± 3.7 days.
Carbon monoxide poisoning-related mortality. During the previous five years (2016-2020), 353 people died in Mongolia as a result of carbon monoxide poisoning, although 1.4 percent, or five people, died in hospitals, one case in Bayan-Ulgii, Zavkhan, and Uvs aimags, and two cases in Ulaanbaatar. However, 98.6 percent of them died prematurely at home or in poisoned places due to a lack of access to health care. The average age of carbon monoxide poisoning deaths cases was 35 ± 19.9 years old, and 71.7 (253) percent were male. The Ulaanbaatar, Selenge, Uvs, and Dornod aimags had the lowest death rate of 0.08-0.21 per 10,000 population, while Khuvsgul and Arkhangai aimags had the highest death rate of 0.96-1.57 per 10,000 population. Conclusions Carbon monoxide poisoning among the population rises during the winter season, however, in the previous five years, 96.5 percent of cases have been poisoned accidentally, particularly 82.6 (1035) percent of cases reported in Ulaanbaatar. According to socioeconomic factors, 41.6 (529) of the cases were male, with an average age of 36.5±15.4 years.
During the preceding five years, carbon monoxide-related mortality in Mongolia was between 0.2 per 10,000 people. Without medical attention, 99.2% of cases died at the exposed location or area. The death rate in Khuvsgul aimags was low, whereas it was high in Ulaanbaatar city. The average age of premature deaths was 35±19.9 years, and 71.7 (253) percent were male.

Various studies conducted worldwide emphasized the importance of identifying gastric cancer risk factors for better prevention and further incidence reduction. A total of 52 identified risk factors for gastric cancer were classified into nine categories in which diet, lifestyle, and infections are leading causes. Gastric cancer morbidity and mortality has an increasing trend annually in our country. In Mongolia, only 1% is diagnosed in the carcinoma stage, 3% in the first stage, 11% in the second stage, 43% in the third stage, 42% in the fourth stage.
The “Gastric cancer risk factors study, 2018” by L.Tulgaa, and D.Ganchimeg confirmed smoking on an empty stomach as a risk factor. B.Gantuya et al`s (2018) study on gastric cancer and helicobacter infection, as well as S.Tsegmed et al`s (2012) gastric cancer prevalence, its risk factors study, had similar results.
B.Gantuya et al (2018) identified the excessive consumption of salt among the gastric cancer diagnosed population in Mongolia. Also, L.Tulgaa and D.Ganchimeg et al`s “Gastric cancer risk factors study, 2018” results reported the daily consumption of salt in tea is a risk for gastric cancer.
L.Tulgaa et al`s (2018) study participants had irregular mealtime such as dinners are at a very late hour, the meals aren`t chewed well, leftover meals, and seasoning consumption. These characteristics were significantly different in two groups with a statistically important result.
Furthermore, the study results suggested a need to provide practical advice on healthy eating to the population as 50% of the participants consumed more than 5 high-risk food products for esophageal and gastric cancer along with combined risk factors.