Background: Ear, nose, and throat (ENT) inflammatory diseases are common conditions that account for a high proportion of healthcare visits. These diseases negatively affect patient’s quality of life, reduce work and learning capacity, and increase healthcare costs. Antibiotics play a crucial role in treatment; however, inappropriate use contributes to the emergence and spread of antimicrobial resistance among pathogenic bacteria. In Mongolia, particularly in Darkhan-Uul Province, data on bacterial pathogens and their antimicrobial susceptibility patterns in ENT infections are limited. Therefore, evaluating the local prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and antimicrobial resistance is essential for guiding clinical practice and promoting rational antibiotic use. Aim: To assess the bacterial pathogens and their antimicrobial susceptibility patterns in inflammatory diseases of ear, nose and throat. Materials and Methods: The study was conducted at the School of Biomedicine, Mongolian National University of Medical Sciences, in collaboration with the Department of Pharmacology and the “Bid” Hospital of Darkhan-Uul Province. Data from ear, nose, and throat swab examinations of patients suspected of having ENT infections in the outpatient department between January 2024 and February 2025 were extracted from the hospital’s centralized database (n=185). Based on the inclusion and exclusion criteria, information from 145 patients was analyzed. The study was designed as a facility-based, retrospective, cross-sectional observational study and was carried out using SPSS - 26.0. Result: A total of 145 patients aged 1-73 years were included in the study, of whom 48.2% (n=70) were male and 51.7% (n=75) were female. Overall, 145 clinical specimens were collected, including nasal swabs 36 (24.8%), throat swabs 56 (38.6%), and ear swabs 53 (36.6%). Bacteriological examination revealed pathogenic microorganisms in 80.7% (n=117) of the specimens. S.aureus was isolated from 65.5% of nasal swabs, 53.6% of throat swabs, and 67.4% of ear swabs. Among S. aureus isolates from ear swabs, 27.6% (n=8) were identified as methicillin-resistant Staphylococcus aureus (MRSA). Antimicrobial susceptibility testing showed that S. aureus isolates from nasal swabs were resistant to amoxicillin (100%), ampicillin (90.0%), erythromycin (87.5%), and azithromycin (81.8%), while they were susceptible to cefazolin (72.7%), doxycycline (80.0%), and vancomycin (75.0%). S. aureus isolates from throat swabs demonstrated resistance to amoxicillin (100%), ampicillin (100%), chloramphenicol (87.5%), and azithromycin (75.0%), but were susceptible to ciprofloxacin (69.2%) and vancomycin (66.7%). S. aureus isolates from ear swabs were resistant to gentamicin (77.8%), clarithromycin (71.4%), azithromycin (66.7%), and penicillin G (66.7%), while higher susceptibility was observed to nitrofurantoin (87.5%), vancomycin (68.8%), and ciprofloxacin (64.7%). For Streptococcus spp, resistance was observed to erythromycin (84.6%), amoxicillin (76.9%), and chloramphenicol (71.4%), whereas susceptibility was noted to amoxiclav (54.6%), cefazolin (63.2%), and cefotaxime (50.0%). Conclusion 1. Staphylococcus aureus predominated in samples from ear, nose, and throat infections, confirming it as the main causative bacterium of these conditions. 2. The predominantly isolated Staphylococcus aureus showed high resistance to antibiotics from the penicillin, macrolide, and aminoglycoside groups.

Background: Pregabalin significantly reduces pain intensity and improves sleep quality and health-related quality of life in patients with neuropathic pain. Since it remains uncertain whether the improvements in sleep quality and quality of life associated with Pregabalin are related to its analgesic properties. Therefore, this study aimed to evaluate whether these clinical outcomes are correlated. Aim: Assessing the Correlation Between patient’s analgesia and sleep quality, health-related quality of life outcomes after pregabalin treatment Materials and Methods: This study was conducted at the Geriatric Hospital of Bayangol District from February, 2026. Patients diagnosed seventy eight with neuropathic pain of any origin who attended the neurology outpatient clinic during the study period were enrolled. Pain intensity, sleep quality, and HRQoL outcomes were evaluated at baseline and at week 8 by means of an 11-point (0-10) numerical rating scale (NRS), the Pittsburgh Sleep Quality Index (PSQI), and the EuroQol EQ-5D-5L score, respectively. The study was designed as an uncontrolled observational analytic study, and statistical analyses were performed using SPSS version 27.0. Result: The mean age of the study participants was 59.5±15.7 years (n=78). Of the participants, 53.8% (n=42) were female and 46.2% (n=36) male. The relationships among pain intensity, sleep quality, and health related quality of life were evaluated using correlation analysis. A strong positive and statistically significant correlation was observed between sleep quality and quality of life (p<0.05), whereas no statistically significant associations were identified among the other variables. Conclusion It was observed that in patients with neuropathic pain, pregabalin reduced pain intensity and that a one-unit improvement in sleep quality was associated with a 0.7-unit increase in quality of life.

This clinical review provides a summary of information on antibiotic-food interactions. The effects of medications vary from person to person due to multiple interactions. These include drug-drug interactions and drug-food interactions, which are influenced by everything an individual consumes. While drug-drug interactions are relatively well studied and understood by healthcare professionals such as doctors, nurses, and pharmacists, drugfood interactions are often overlooked, even by medical professionals.
As a result, medications' effects may become stronger, weaker, or completely absent, and in some cases, this may lead to toxicity. Therefore, this review aims to enhance awareness of drug-food interactions among healthcare professionals and the general public to improve treatment outcomes. Food-drug interactions are more noteworthy compared to other interactions. This is because dietary habits are often not recorded in a patient’s medical history and are not always included in consultations with healthcare professionals. However, the risk of adverse effects is the same for both food and medication.
Particularly, solid dosage forms such as tablets, capsules, and pills should be taken with water. If taken with other beverages— such as milk, alcohol, coffee, or fruit juices— they can affect the drug's pharmacokinetics (absorption, metabolism, distribution, and excretion), potentially increasing side effects or suppressing the drug’s effectiveness. Spoiled food, food that has not been stored in a refrigerator, or aged, pickled, fermented, or smoked foods may contain tyramine. Therefore, special caution should be taken to avoid consuming these foods during medication treatment. Tyramine is also found in foods like bananas, avocados, raisins, raspberries, and soy sauce.
When Linezolid is taken with foods high in tyramine, it can cause a sudden and dangerous increase in blood pressure. Thus, it is important to check food labels and ingredients carefully.

This article provides an overview of the clinical evidence of interactions between herbal and conventional medicines. Herbs involved in drug interactions – or that have been evaluated in pharmacokinetic trials – are discussed in this review. While many of the interactions reported are of limited clinical significance and many herbal products (echinacea, valerian) seem to expose patients to minor risk under conventional pharmacotherapy, a few herbs, notably St. John’s wort, may provoke adverse events sufficiently serious about endangering the patient’s health. Healthcare professionals should remain vigilant for potential interactions between herbal medicines and prescribed drugs, especially when drugs with a narrow therapeutic index are used. Hypericum perforatum L. (St. John’s wort) extracts are widely used as a safe alternative to conventional antidepressant drugs for mild to moderate forms of depressive disorders. St. John’s wort represents the herbal product that is most involved in herb-to drug interactions. The aim of this article is to provide an overview of the clinical data regarding the E2 interactions between herbal remedies and prescribed drugs. For patients on prescription medications, the concomitant use of herbal medications can cause serious and adverse effects. It is the responsibility of health professionals to be well informed about the clinical evidence of herb-drug interactions.

Background: Induction of labor is a procedure performed to prevent maternal and perinatal morbidity and mortality. The effects of birth control pills on babies are still controversial. Therefore, we conducted this study to compare the effects of oxytocin and misoprostol on fetal blood gas parameters. Aim: To compare the effects of misoprostol and oxytocin used in labor induction on umbilical cord blood parameters Materials and methods: We conducted this study among mothers who gave birth in the NICU, according to the inclusion criteria, a control group (n=30), misoprostol alone vaginally (n=30) and oxytocin drip alone (n= 30) and oxytocin with misoprostol group (n=30) 4 groups used 100 mothers were selected respectively. Umbilical artery blood was sampled and umbilical artery blood pH, pCO2, pO2, HCO3, and VE (blood base excess) parameters were measured in the laboratory. The umbilical cord blood acid-alkaline parameters and lactate levels were analyzed and evaluated using COBAS C311 and COBAS B221 instruments. It was compared and determined using SPSS26 and EXCEL programs. Results: The average age of all mothers included in the study was 27.87±6.12, the average gestation period was 39.6±0.7 weeks, and the average weight of the newborn was 3466±323 gr. The average umbilical cord blood pH value was 7.34±0.04 in the control group, 7.25±0.07 in the oxytocin group, 7.27±0.04 in the misoprostol group, and 7.24±0.04 in the oxytocin and misoprostol group. And lactate valie was 5.8 in the control group, 7.5 in the oxytocin group, 9.87 in the misoprostol group, 8.7 in the combined group. Conclusions Compared to the group that did not use labor-inducing drugs, the mean pH of umbilical cord blood and lactate level were higher or statistically significant in the 3 groups that used labor-inducing drugs, indicating that birth-inducing drugs affect the umbilical cord blood parameters.

Outcomes of the retinopathy of prematurity screening and treatment in Mongolia Background: Retinopathy of prematurity (ROP) is a disease characterized by abnormal retinal vasculature that can have devastating visual consequences. Despite evidence that early detection and treatment can prevent blindness, ROP remains a leading cause of pediatric blindness worldwide. We aimed at investigating the outcomes of ROP screening, intravitreal anti–vascular endothelial growth factor (VEGF) and laser surgery in the treatment ROP and describe an evidence-based and specific process for identifying birth weight and gestational age screening guidelines in Mongolia utilizing telemedicine. Materials and methods: This was a retrospective of prematurity infants screened ROP from 2012 September to July 2020 and prospective cohort study of premature infants with treatment-requiring ROP who received intravitreal injections, laser surgery and combined therapy from 2015 December 01 to January 31, 2017. Demographic factors, diagnosis and clinical course were recorded in a de-identified manner using REDCap, a secure, web-based platform to collect image and demographic data. The IRB approved the study protocol not requiring parental consent due to the de-identified nature of the data which was used for program monitoring purposes. Indirect ophthalmoscopy and Retinal imaging was performed using RetCam (Natus Medical, Pleasanton, CA) and images were uploaded to the web-based platform which could be accessed by the Mongolian ophthalmologist for reference. Each eye was evaluated by the local Mongolian ophthalmologist for the presence or absence of ROP, zone of vascularization, stage, plus disease, and aggressive posterior ROP (AP-ROP). The diagnosis and classification of ROP for this current study were determined by examination using indirect ophthalmoscopy, and treatment plans were determined according to the International Classification for ROP and the Early Treatment for ROP Study (ET-ROP).2,13 Regression analysis to determine association between BW and GA and the development of ROP. Results: A total of 9126 premature infants with BW ≤ 2500 g and/or GA ≤ 36 weeks were screened for ROP during the study period. 327 (3.5%) of the 9126 infants screened required treatment. The193 infants who received ROP screening had a mean GA of 30.09 ± 1.7 weeks, and mean BW of 1500.3 ± 125.42g. The BW of infants in this study ranged from 750g to 2000g, and the GA at birth ranged from 25 to 35 weeks. The BW of infants in this study ranged from 750g to 2000g, and the GA at birth ranged from 25 to 35 weeks. There were 96 boys (49.7%) and 97 girls (50.3%). Among infants receiving treatment, the highest BW was 2000g (born at 31 weeks GA), and the oldest was 34 weeks (with a BW of 1300g). The distribution of birth weight and gestational age in Mongolia was similar to other low-middle income countries, with higher birth weight and older gestational age. As birth weight and gestational age decreased, relative risk of developing ROP increased. Conclusions: After treatment, resolution of ROP was noted in approximately 90 % of the patients who had treatment-requiring ROP. 10 % of patients treated with IVB, IVR, Laser surgery and combined therapy however, did not respond and progressed to retinal detachment. This prospective study provides information about the development of ROP in preterm infants in the capital city of Mongolia. The distributions of BW and GA among infants developing ROP in Mongolia differ from those found in higher-income countries, and are comparable to other low and middle-income countries. We used a secure, web-based data collection and retrieval system that could be extended to multiple countries, which is now equipped with a telemedicine platform enabling remote grading of fundus images.

The Mongolian plants considered to possess medicinal properties may contain novel compounds since they are exposed to severe conditions; such plants could become good candidates for modern drug discovery programs. Daurian Thermopsis (Thermopsis lanceolata R.Br.= Th.dahurica Czefr.), Gobian Thyme (Thymus gobicus Tschern.) and Mogilev Mallow (Malva mohileviensis Downer) are separately used as mucolytic and anti-inflammatory treatment in non-conventional medicine. Therefore, weprepared extract of these herbals compound called as a Tetima and to evaluate it’s acute toxicity. It isimportant to produce mucolytic effective new pharmaceutical preparation used for upper and lowerrespiratory tract inflammatory disease.Tetima herbal compound extract was prepared in ethanol, the ratio of herbals to ethanol was 1:10. Healthy 25 white albino mice (male weighing between 17-30 gram) used in this study. They were kept in large airy cages in groups of 5 animals per cage with free access to food and water. Five doses (8-20 g/kg) were then chosen for the determination of intraperitoneal LD50 in mice and given to five groups of albino mice. The animals were observed for first 2 hours and then at 6th and 24th hour for any toxicsymptoms. After 24 hours, the number of deceased mice was counted in each group. The percentage of animals that died at each dose level was transformed and then LD50 determined by the methods of Karber and Pershin.G.N.The LD50 of Tetima herbal compound in mice was determined to be 14.3 g/kg after intraperitonealinjection. There was no difference occurred between Karber and Pershin methods to evaluate acute toxicity. In the animals receiving intraperitoneal injection, the abdominal muscle contractions and ataxia was observed, which persisted for few hours. At the 6th hour they were drowsy and less responsive. The severity of these effects was related to the level of dose. However, at 24th hour most of the survivors had recovered from these symptoms.Tetima herbal compound extract is a relatively safe, particularly when given intraperitoneal inject toexperimental animals.

BackgroundClimate change, as defined by the United Nations Convention on Climate Change, is a “Change of climate which is attributed directly or indirectly to human activity that alters the composition of the global atmosphere and is observed over time”. In 2001 an Initial Communication on Climate Change was prepared by the Government as part of its obligations under the UNFCCC. One of its recommendations was for “creating public awareness among a wide range of stakeholders including public, private and community sector organizations”. GoalThe main goal of the study was to develop recommendations and measures on prevention from diseases and adaptation to climate change by assessing knowledge, attitude and practice (KAP) of population towards climate change. Based on the main goal the following objectives were setup. Therefore addressing the different levels of knowledge and types of attitudes and practices people have towards climate change must initially be dealt with at the local level where site specific variations can be accounted for. Once research has been undertaken at the local level it can later inform decisions and policy at the regional, continental and global levels on how to incorporate site specific variations with in the greater context of the global threat.Objectives:1. To determine knowledge and attitude of population towards climate change;2. To determine practice of population on some adverse consequences of climate change;3. To develop recommendations and measures on prevention from and adaptation to climate change;Materials and MethodsThe study was at once carried out by means of questionnaire. In order to assess KAP of population, the data was collected using a card with 38 questions in three chapters which previously produced and ratified. The questionnaire was structured into 4 sections; demographics, knowledge, attitudes and practices. Two sums in an aimag from each climate zone of Mongolia were selected. In total, 2258 respondents aged 15 to 64 were involved from eight sums in four aimags (Zavkhan, Selenge, Dornod and Umnugovi), and two districts in Ulaanbaatar. The study data was input to computer using EPIDATA-3.6 software and statistically analyzed using SPSS-18.0 software.ResultsA total of 2258 individuals were interviewed. 44.1% 44.1% (995) of the participants was residents of Ulaanbaatar city and remained percentages accounted for residents living in the center of aimags and soums. 56.7% (1281) of participants were women and 43.3% (977) were men aged with 35.2±15.1 in average. Most of the study participants had educated with medium level (34.8%) and high level (30.0%). Employment percentage is 47.5% (1073). However, most respondents interpreted the meaning of climate change as “a change in weather,” “a change in normal climate conditions,” or “a change in temperature” – answers that requires more common sense than climate change savvy. Global warming is one of the evident of climate change. To know study participants awareness about climate change we used terminology of global warming. 25.3% (571) of the total participants answered that climate change revealed by the overheating or warming earth surface. 42.4% of the respondents answered the climate change could affect to health, 33.2% to environment and 16.3% to economy. 84.5% (1908) of the study participants agreed with that climate change has been started. Most of them (71.3%, 1824) allowed that people’s improper use of nature tend to global warming. When ranging the protection practices during the strong storm means of timbering the houses or gers accounted for 42.5% (960). Study participants supported the following activities; 41.2% (931) agreed that is it necessary to increase health services and 34.1% (769) suggested that it is better to enhance training and propagation for increasing awareness of population about climate change adaptation procedures and some information on climate changes and protection events. 85.2% (1923) of the study participants answered that they want to get the information on climate change from public TV.ConclusionsAlthough knowledge on global warming as the climate change was poor among the respondents, they agreed the climate change has already been started worldwide as well as in Mongolia. Only half of the respondents have had practice to prevent themselves from natural disaster.