Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are among the most common forms of anemia worldwide. Although the underlying causes of ID may vary depending on a country’s developmental level, lifestyle, and other factors, blood loss remains the principal cause leading to ID and subsequent IDA. In hemophilia, recurrent bleeding due to deficiencies of coagulation factors (FVIII, FIX, FXI) can lead to ID, which may progress to IDA and adversely affect the quality of life in these patients. The absence of studies evaluating the prevalence of ID and IDA among hemophiliac patients in Mongolia provided the impetus for this investigation. Aim: To assess the prevalence of ID and IDA among patients with hemophilia. Materials and Methods: A cross-sectional study was conducted among 45 patients with hemophilia registered at the Hemophilia Comprehensive Center (HCC), Mongolia-Japan Hospital, Mongolian National University of Medical Sciences. All participants underwent laboratory testing, including complete blood count (CBC) and serum ferritin levels—were performed using the SYSMEX XN2000 and COBAS BM6010 analyzers. Data analysis was carried out using SPSS 27.0 and MS Excel 2010. Results: Among the 45 cases, 41 were Hemophilia A and 4 were Hemophilia B. Reduced serum iron levels were found in 33.3% (15), and low ferritin levels were observed in 22.2%. Detailed blood tests revealed microcytic hypochromic changes in 43.9% (18) of Hemophilia A cases and in 100% (4) of Hemophilia B cases. The overall prevalence of ID was 13.3%, while the prevalence of IDA was 22.2%. Among the IDA cases, 90.0% were classified as mild and 10.0% as moderate. Notably, 80.0% of the IDA cases occurred in children under 15 years of age. Conclusion ID and IDA are common among hemophiliac patients. The high prevalence among children under 15 years of age suggests an age-related predisposition, emphasizing the need to improve disease management and to implement preventive measures against anemia in this population.

Background: Malaria is caused by parasite of the genus Plasmodium and considered one of the biggest public health issues because almost half of the world’s population is at risk of contracting malaria. It causes 2% of the world’s total deaths and millions of clinical infections. In 2022, 94% of cases and 95% of deaths occurred in the WHO African Region. Cerebral malaria the most severe neurological complication of infection with Plasmodium falciparum malaria. It is a clinical syndrome characterized by coma and asexual forms of the parasite on peripheral blood smears. The neurological complication, induced by cerebral malaria is irreversible and lethal, therefore it is of great significance to unravel its exact etiology, which may be beneficial for the effective management of this severe disease. In Mongolia, malaria normally not present unless the disease was contracted abroad. Considerable attention in malaria control and elimination is needed, yet, increasingly, domestic hospitals are unfamiliar with it, and so there is a risk of being overlooked. The following is the second case, to our knowledge, of cerebral malaria in Mongolia. Conclusion Although Mongolia is not a malaria-endemic region and routine malaria testing is not commonly performed, the number of imported cases is increasing due to the growing mobility of the population—travel, study, tourism, and peacekeeping missions to Africa and Southeast Asia. Therefore, neurologists should be aware of the possibility of cerebral malaria when evaluating patients with neurological deficits who have a history of travel to malaria-endemic areas. This case highlights important clinical, imaging, and laboratory considerations for suspecting and diagnosing malaria in such patients.

Introduction: The endometrium is to receive the embryo and endometrial receptivity predicts successful implantation during window of implantation (WOI). During implantation and pregnancy ER,PR,Ki67 significant controllers of endometrial decidualization. The PRP is promoting cell proliferation neoangiogenesis and anti-inflammatory effects, facilitating successful implantation indicating the safe as well as a potential therapeutic response to its application in patients with RIF with thin endometrium. Goal: Our aim was to further elucidate the role of WOI as a diagnostic and prognostic tool to RIF with thin endometrium in the fertility field. Also the importance of PRP treatment. Materials and Methods: A prospective study was done of 72 infertile thin endometrium women with history of recurrent implantation failure (RIF). All women underwent hysteroscopy followed by endometrial sampling for histological examination. WOI was studied using the immu-nohistochemicall method of determining Ki67, ER, PR, 6 tissue preparations were excluded due to an unsatisfactory amount of tissue. Therefore, data about tissue specimens from 66 patients were included in statistical analysis. Differences in implantation rate between 2 groups were evaluated using the chi square test. Endometrial thickness was calculated by a repeated measures ANOVA test with greenhouse method. This study received approval from the Ethics Committee under the reference number 2021/3-202109 and conducted at the CL fertility clinic. Results: In this study, out of 72 cases, 6 were removed, 42 were synechiae, 24 were polyp. Ki67, ER, PR immunohistochemistry expression was found in 66 and endometrial delay was diagnosed 73,6% (Figure 1). Endometrial thickness was significantly increased with the PRP group. After adjusting the WOI, significant increase in implantation 58% and clinic pregnancy 38% (Figure 2). Conclusion Adjusting WOI, receiving PRP treatment in infertile women with thin endometrium significantly associated with implantation rate and pregnancy rate prognostic indicators including Ki67 proliferation index, ER,PR.

Background: To prevent and combat the spread of the COVID-19 pandemic, the Government of Mongolia has implemented measures such as movement and time restrictions, social distancing and isolation, closure of schools, kindergartens and public places, immunization, and others. It has caused adverse consequences for people, social relations, and the economy, causing health, social, economic, and humanitarian crises. Not only does this situation, medical students, as frontline healthcare workers, are more susceptible to virus infection. Vaccines against COVID-19 have been researched quickly due to the pandemic and are being used under emergency use authorization. In our country the approach of mixing vaccine doses from different manufacturers was used (fractional doses). Therefore, there is no study on the exposure of medical students to the COVID-19 infection and the adverse effects after receiving a dose of a heterologous vaccine. Objective: To study the exposure to the COVID-19 infection and vaccination status of medical students. Methods: The survey was conducted from November 2023 to December 2023 using a cross-sectional study design, and 170 students who study at ASUSU and live in the dormitory were included. Results: A total of 170 students participated in the study. 55.9% (n=95) of them were in the first year, 22.4% (n=38) were in the second year, 10% (n=17) were in the third year, 7.6% (n=13) were in the fourth year, 2.4% (n=4) were from the 5th year and 1.8% (n=3) were from the 6th year students. 88.2% (n=150) of students were female and 11.8% (n=20) were male. In this study, 37.1% of the students were infected by COVID-19 infection previously. Among them, 50% of the students were infected from family members, 16.7% from the school environment, and 15.2% did not know about the source of infection. 76.2% of the respondents were diagnosed with COVID-19 in a medical institution, and forty-one students answered that they were treated at the hospital. 83% of the cases were treated at home and were cured within 14 days. In contrast, 93.8% of the hospitalized students were treated within four months to 1 year. The current study demonstrates neurological, respiratory, sensory, cardiovascular, psychiatric, digestive, and dermatological symptoms were in 37.6%, 24.1%, 27.6%, 17.6%, 11.8%, 11.2%, and 10% of the students who participated in the study, respectively. For a year or more, symptoms of all organ systems were present, but neurological symptoms appeared to be the highest. 55.9% (n=115) of the enrolled students received 3 or 4 doses of the vaccine, 3.5% (n=6) did not receive the vaccine. In total, 35% (n=60) of the enrolled students experienced side effects and 65% (n=106) had no side effects. Conclusion In this study, 37.1% of the students were infected by COVID-19 infection previously. According to the current study, symptoms related to the nervous system was the most prevalent and 55.9% (n=115) of the enrolled students received 3 or 4 doses of the vaccine. In total, 35% (n=60) of the enrolled students experienced side effects.

Background: We aimed to study the etiology and transmission route of diseases introducing the modern, rapid and high-sensitivity molecular genetic diagnostic methods for salmonellosis. Material and Method: In the study, we collected 680 stool samples and defined organisms of food intoxication by identification of bacteria, polymerase chain reaction (PCR) and determined serotype and antibiotic resistance. Result: Salmonella spp was detected from the stool of 25 (42.3%) patients out of 59 outpatient clinic and of 170 (27.4%) patients out of 621 inpatient clinic with diagnosis of food intoxication. In total there was detected 195 salmonella spp, and out of this isolated Sal. typhimurum in 193 (98.9%), and Sal. enteritidis was in 2 (1.1%) patients, respectively. We defined Sal. typhimurum in selected 32 cultures and did not detect resistant gene DT-104 ACS-SuT by PCR. Conclusion As resulted in the survey, we defined 195 (28,6) Salmonella typhimurum among the 680 patients who were suffered from food intoxication, and revealed fast foods, animal derived foods such as chicken, fish caused the food intoxication. Sal. typhimurium not resistance to antibiotics.

Introduction: Due to cervical spondylosispatients with cervical stenosis who hadhyperextension trauma developed spinalcord stress and contusions, tetraplegia anddisability and mortality. Cervical spondylosispatients with hyperextension traumatreatment management still not clearedout throughout the world and very fewresearch has been done in our country.We have been introduced our surgical andrehabilitation comparison research study ofcervical spondylosis trauma in 2015. Our goalis to develop treatment management forthe hyperextension trauma in patients withcervical spondylosis.1. To compare surgical treatmentresults between patients who hadhyperextension injury to the cervical spinewhich were treated at the Departmentof Spinal Surgery of the National Traumaand Orthopaedic Research Center ofMongolia.2. To study biomechanical effects after thesurgeryMaterial and methods: 42 cervicalspondylosis patients with hyperextensioninjury have been chosen retrospectively toevaluate the surgical, conservative, andrehabilitative treatments and results wereanalyzed by SPSS, EXCEL program who weretreated at the Department of Spinal Surgeryof the National Trauma and OrthopaedicResearch Center of Mongolia from 2012-September 2016. Over 20% canal stenosiscases were chosen for laminectomy andanterior discectomy and fusion surgeriesalong with conservative and rehabilitationtreatment. Up to 20% canal stenosis 10cases which is 23.8% of all patients weretreated by conservative treatment.Results: From 42 patients there was 10females and 32 males. Average ages were56±7.9. By the cause of injury 62% werecar accident, 23% motorcycle accident, 10%fall from horse riding and 5% were otherfalls respectively. All patients had neurologicdeficits according to the level of spinal cordinjury. 36 (85.7%) patients had C4-C5 andC5-C6 level injury and 15 (35.7) patients wererecovered from spinal shock after high dosesteroid treatment. According to the X-RAYall patients had cervical spondylosis signand 4 (9.5%) of them had facet fractureswith stable spine condition. After CT scanspinal cord injury located at C3-C4, C4-C5and C5-C6 levels and patients developedfacet arthrosis, ossification of ligaments andintervertebral discs. Clinical signs and CT scans were evaluated and 4 cervical spondylosispatients with hyperextension injury hadlaminectomy and 2 patient had anteriordiscectomy and fusion surgeries. Canalstenosis is decompressed after laminectomysurgery and cervical lordosis is reduced by 7degrees but after anterior discectomy andfusion surgery cervical lordosis is reducedby 3 degrees. Neurological deficit increasinglaminectomy cases had C5 palsy becauseof cord shift (2.4-4mm) which resulted bydenticulate ligament tethering.Conclusion: There were no significantstatistical (P≤.05) differences betweensurgical and rehabilitation treatmentsin cervical spondylosis patients withhyperextension injury who’s canal stenosiswere below 20% [1,2,3,4,5].In our practice itis essential to make laminectomy and anteriordiscectomy and fusion surgeries in 72 hoursafter trauma to help the patient recoverfrom the spinal shock and reabsorption ofcord contusion. For one or two level canalstenosis especially with the OPLL, artificialdisc replacement and ADF surgeries showedbetter results. In multiple level canal stenosiswith OLF and OPLL cases laminectomyand laminoplasty are choice for surgery. Incomparison to foreign study/ Biomechanicalinvestigation of spinal cord injury and diseasein cervical spine Batbayar.K Seoul.2016[2]/ our surgical treatment showed similarresults. Among cervical spondylosis patientswith hyperextension trauma cases whotreated in Spine Department of NationalTrauma and Orthopaedic Hospital, mortalityand disability is increasing and it is essentialto follow correct diagnostic and treatmentalgorithms.

Spent brewer’s yeast Saccharomyces cerevisiae was hydrolysed using bovine pancreatictissue as an enzyme source. The resulting hydrolysate contains 4.7% amino nitrogenand the ratio Namin/Ntot was determined as 0.6. Moreover, other physico-chemicalparameters of the hydrolysate were also comparable with the same products on foreignmarkets. Toxicity of hydrolysate is low (LD50 2,5 g/kg), microbiological and heavy metalcontamination were in required range. The IC50 value of obtained yeast hydrolysate’santioxidative activity according to the DPPH assay was 1.6±0.5 mg/ml, while IC¬50 ofthe yeast hydrolysate rich in Cyclo-His-Pro evaluated as 1.9 mg/mL.

BackgroundTo investigate the pharmacological actions of three groups of drugs containing: Plantago major L. extract, Calendula officinalis L. extract, or mixtures of both. The three investigational drugs were compared to Omeprazole, a standard drug produced in Bulgaria, which inhibits the release of enzymes of the secretary cells of the mucous membranes of the stomach.Materials and MethodsThe effects of the medicinal substances were investigated on “Wistar” breed of white rats. Pathological model of ulcers was formed by injecting the rats with 10% acetic acid (Okabe, Koth.S 1978).The experimental animals were given any of the three versions of the new herbal medicine and compared to the rats given Omeprazole. After treatment the ulcer index, MDA and sialic acids in the serum were determined.ResultThe results showed that in the third day of the investigation, the sialic acid levels in the blood of the test group, which was given the mixture of the two plants, was significantly reduced (p<0.05) compared to the control group.ConclusionThis indicates that medicinal substances given to the rats, which contained the mixture of Plantago major L. and Calendula officinalis L. has accelerated the regeneration of the stomach, decreased the stomach cell damage and overall has antioxidant protective effects.

Background: To investigate the pharmacological actions ofthree groups of drugs containing: Plantago major L. extract, Calendula officinalis L. extract,or mixtures of both. The three investigational drugs were compared to Omeprazole, a standard drug produced in Bulgaria, which inhibits thereleaseof enzymesof the secretary cellsof the mucous membranesof the stomach.[1]Materials and Methods:The effects of the medicinalsubstances were investigated on “Wistar” breed of white rats. Pathological model of ulcers wasformed by injecting the rats with 10% acetic acid./ Okabe, Koth.S1978 /. [2] The experimental animals were given either of the three versions of the new herbal medicine and compared to the rats given Omeprazole. After treatment the ulcer index, MDA and sialic acids in the serum were determined. [3]Result: The results showed that in the third day of the investigation, the sialic acid levels in the blood of the test group, which was given the mixture of the two plants, was significantly reduced (p<0.05) compared to the control group.Conclusion:This indicates that medicinal substances given to the rats, whichcontained the mixture of Plantago major L. and Calendula officinalis L. has accelerated the regeneration of the stomach, decreased the stomach cell damage and overall has antioxidant protective effects.Key words: Stomach, gastric ulcers, acetic acid, sialic acidReferences:1. алтанцэцэг а, амбага м. амьтнû гаралтай зарим бэлдмэлийн ходооднû салст бүрхүүлийн гэмтлээс хамгаалах идэвхи. “монгол туургатнû уламжлалт анагаах ухаан” оу-ûн эрдэм шинжилгээний бага хурлûн илтгэлийн хураангуй уБ .1995, х 40-43.2. Okabe S. Koth J.L and others. “Amer.jour. dig,dis,1971, vol16. pp.277-2893. стальная и.д и др. методопределения мда с помошью тиобарбитуровой кислотû. совр. методû биохимии.м, 1977, с 66-68.

BackgroundLiver protecting effect of liver hydrolysate is studied on CCl4 induced by acute toxic hepatitis on rats compared with “Raw Liver Glandular” which is similar product of “Swanson”, USA. Result was confirmed with histological study.Materials and MethodsCarbon tetrachloride-CCl4 is considered as a direct hepatotoxin which produces centri-lobular necrosis and steatosis. The mechanism of acute toxic hepatitis induced by CCl4 involves lipid peroxidation of membrane bound fatty acids which result in destructing the cell membrane and the intracellular organells of the hepatocyte.Result:As study result, after 7 days CCL4 exposure, experimental group’s serum ALAT (p<0.01), GGT (p<0.05) and ALP (p<0.05) levels decreased rapidly compared with control groups.ConclusionAlthough, liver hydrolysate is not medicine for treatment liver damage, it might be improved regeneration process in the damaged liver cells. As result, histomorphological study came to the following conclusion: in the seventh day of the model of acute toxic hepatitis of the liver in rats, cytoplasm vacuoles of hepatocytes were decreased sharply, hepatocytes became multilateral, “Kupffer cells” were increased, young hepatocytes were streamlined as columnar-cells, capillaries were became visible and was began regeneration. There were reported that bovine and pork protein hydrolysate contains essential amino acids with antioxidant effect which prevents liver cells from oxidative stress. Besides it, liver hydrolysate containing amino acids, vitamin B1, B6, folic acid and some minerals improves metabolism and regeneration process of damaged liver cells.