Objective:To provide references for aeromedical support by investigating the effect of training at high altitude on acute hypoxia tolerance of pilots.Methods:Eighteen high performance fighter pilots who had returned to plain for 1 week as they finished 3-month residence in plateau were chosen as training group and 36 pilots who flied same aircraft type but without plateau stay and training were assigned as control group. Both groups received anti-G and anti-hypoxia training. The acceptance line of hypoxia experience training was defined to 2 min and the arterial oxygen saturation (SaO 2) and the heart rate of pilots were tested every 20 s. The anti-G and anti-hypoxia ability detector of pilots and BeneView T6 ECG monitor were used for training, assessment and monitoring. Results:SaO 2 level in the training group was significantly higher than that in the control group at the corresponding time point from the 60 s of the training, and the differences was statistically significant ( t=2.63, 3.32, 4.79, 4.32, P=0.011, 0.002,<0.001,<0.001). The average of SaO 2 in the control group decreased rapidly with the extension of hypoxia time, while the average of SaO 2 in the training group decreased slowly with the extension of hypoxia time. The average of effective consciousness time of the training group [(441.11±67.03) s] was significantly longer than that of the control group [(195.00±31.49) s], and was 2.26 times of the control group, the difference was statistically significant ( t=17.74, P<0.001). Conclusions:After stationed and trained in plateau, the SaO 2 and the effective consciousness time of high performance fighter pilots under acute hypoxia have been significantly improved. Short term chronic hypoxia process can significantly improve the acute hypoxia tolerance of pilots, which is conducive to the effective response to high aerial hypoxia.

Objective:To provide references for aeromedical support by investigating the effect of training at high altitude on acute hypoxia tolerance of pilots.Methods:Eighteen high performance fighter pilots who had returned to plain for 1 week as they finished 3-month residence in plateau were chosen as training group and 36 pilots who flied same aircraft type but without plateau stay and training were assigned as control group. Both groups received anti-G and anti-hypoxia training. The acceptance line of hypoxia experience training was defined to 2 min and the arterial oxygen saturation (SaO 2) and the heart rate of pilots were tested every 20 s. The anti-G and anti-hypoxia ability detector of pilots and BeneView T6 ECG monitor were used for training, assessment and monitoring. Results:SaO 2 level in the training group was significantly higher than that in the control group at the corresponding time point from the 60 s of the training, and the differences was statistically significant ( t=2.63, 3.32, 4.79, 4.32, P=0.011, 0.002,<0.001,<0.001). The average of SaO 2 in the control group decreased rapidly with the extension of hypoxia time, while the average of SaO 2 in the training group decreased slowly with the extension of hypoxia time. The average of effective consciousness time of the training group [(441.11±67.03) s] was significantly longer than that of the control group [(195.00±31.49) s], and was 2.26 times of the control group, the difference was statistically significant ( t=17.74, P<0.001). Conclusions:After stationed and trained in plateau, the SaO 2 and the effective consciousness time of high performance fighter pilots under acute hypoxia have been significantly improved. Short term chronic hypoxia process can significantly improve the acute hypoxia tolerance of pilots, which is conducive to the effective response to high aerial hypoxia.

Objective To study the effects of perinatal and postnatal cytomegalovirus(CMV) infection on infantile physical development and nerves mental growth. Methods We observed forty-eight cases of perinatal and postnatal CMV infection infants and twenty-two cases of non-CMV infected infants. We compared the physical development between two groups at birth ,3 months and 1 year of age, and evaluated development quotient (DQ) at 1 year of age. Results There were no significant differences of baby length,weight, head circumference between two groups at birth and 3 months (P > 0.05). The averages of baby length,weight,and head circumference were all in the normal range,which showed no significant differences between two groups(P > 0. 05). There were no significant differences in DQ of rough movement,accurate movement, adaptability, language and sociality ability between two groups at 1 year of age (P > 0.05). The averages of total DQ were in the normal range, which showed no significant difference between two groups as well (P > 0. 05). According to the evaluation hierarchies, DQ values of two groups were mostly in normal level range, and there also was no significant difference(x2 = 1. 026, P > 0. 05). Conclusion The perinatal and postnatal cytomegalovirus(CMV) infection has no significant adverse effects on infantile physical development and neuro-psychological development.

The antiEGFR monoclonal antibodies cetuximab and panitumumab have been proven to be efficient in MCRC. The degree of EGFR expression (as confirmed by immunohistochemical analysis) did not correhte with the clinical response. In this review, we describe the current status of markers that might identify patients who are likely to benefit from treatment with cetuximab or panitumumab. These molecular markers include KRAS mutations, EGFR copy number, EGFR ligands (EGF, epiregulin), cyclin DI, IgG FcγR (FCGR2A-HI31R and FCGR3A-V158F), and nuclear factor-κB, that are crucial to avoid anti-EGFR treatment toxicity and reduce treatment cost.