Objective To investigate serum levels of eosinophilic neurotoxin(EDN),interleukin(IL)-13 and transforming growth factor(TGF)-β1 in children with recurrent wheezing of mycoplasma pneumoniae(MP)infection and analyze risk factors of recurrent wheezing with MP infection.Methods A total of 80 children with MP infection were divided into the MP infection recurrence wheezing group(45 cases)and the MP infection non-wheezing group(35 cases)according to the previous history of MP infection with wheezing,and 35 children with acute attacks of bronchial asthma were selected as the asthma group.The levels of EDN,IL-13 and TGF-β1 were determined by enzyme-linked immunosorbent assay.Multivariate Logistic regression analysis was performed to analyze risk factors of MP infection recurrence and wheezing.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of EDN,IL-13 and TGF-β1 on MP infection recurrence and wheezing.Results Compared with the non-asthmatic group,levels of EDN,IL-13 and TGF-β1 were higher in the recurrent asthmatic group and the asthmatic group(P＜0.05).There were no significant differences in EDN,IL-13 and TGF-β1 levels between the asthma group and the recurrent asthmatic group.Univariate analysis showed that the birth weight was lower in the recurrent wheezing group than that of the non-wheezing group,and the proportion of atopic constitution,the first and second degree relatives allergy history,smoke exposure and hospital stay≥7 d were higher than those of the non-wheezing group(P＜0.05).Multivariate Logistic regression analysis showed that higher levels of EDN,IL-13,TGF-β1,atopic constitution and smoke exposure were risk factors for recurrent wheezing of MP infection(P＜0.05).ROC curve results showed that the AUC of EDN,IL-13 and TGF-β1 for predicting the recurrence of MP infection and wheeting was 0.688,0.662 and 0.689,respectively,and the AUC of the combined prediction of EDN,IL-13 and TGF-β1 was 0.765,which was the most effective than each single index.Conclusion Serum levels of EDN,IL-13 and TGF-β1 increase in children with recurrent wheezing of MP infection,and their serum levels may predict repeated wheezing in children after MP infection,providing guidance for clinical intervention.

Objective:To assess the quality of life in college students and to explore its related factors.Met-hods:A sample of 1 423 college students were recruited and assessed with the short form Quality of Life Scale-12(SF-12),Patient Health Questionnaire-9(PHQ-9),Generalized Anxiety Disorder-7(GAD-7),Insomnia Severity Index(ISI),Somatic Symptom Scale-8(SSS-8),Sick,Control,One,Fat and Food(SCOFF),Perceived Stress Scale(PSS-10),and Brief Version of the Difficulties in Emotion Regulation Scale(DERS-16)to evaluate quality of life,depressive,anxiety,insomnia severity,somatic symptoms,eating disorders,stress perception,and emotion regulation abilities,respectively.A self-made self-injury risk screening questionnaire was used to screen self-harm thoughts and behaviors.Results:In the sample,the rates of college students with SF-12 mental and physical quality of life scores below 50 were 81.7％and 47.8％,respectively.Multiple linear regression analysis showed that there was a positive association between family per capita monthly income and SF-12 mental quality of life scores(β=0.04,P＜0.05),while PSS-10(β=-0.27,P＜0.001),PHQ-9(β=-0.25,P＜0.001),DERS-16(β=-0.23,P＜0.001),and GAD-7(β=-0.11,P＜0.001)scores were negatively associated with SF-12 mental quality of life scores.The SSS-8 scores were negatively associated with SF-12 physical quality of life scores(β=-0.45,P＜0.001).Conclusion:The study shows that a higher percentage of college students have a lower quality of life;the higher the levels of perceived stress,depression,emotional regulation difficulties,and anxiety,the lower the mental quality of life,and the more severe the physical discomfort symptoms,the lower the physical quality of life.

Objective:To assess the quality of life in college students and to explore its related factors.Met-hods:A sample of 1 423 college students were recruited and assessed with the short form Quality of Life Scale-12(SF-12),Patient Health Questionnaire-9(PHQ-9),Generalized Anxiety Disorder-7(GAD-7),Insomnia Severity Index(ISI),Somatic Symptom Scale-8(SSS-8),Sick,Control,One,Fat and Food(SCOFF),Perceived Stress Scale(PSS-10),and Brief Version of the Difficulties in Emotion Regulation Scale(DERS-16)to evaluate quality of life,depressive,anxiety,insomnia severity,somatic symptoms,eating disorders,stress perception,and emotion regulation abilities,respectively.A self-made self-injury risk screening questionnaire was used to screen self-harm thoughts and behaviors.Results:In the sample,the rates of college students with SF-12 mental and physical quality of life scores below 50 were 81.7％and 47.8％,respectively.Multiple linear regression analysis showed that there was a positive association between family per capita monthly income and SF-12 mental quality of life scores(β=0.04,P＜0.05),while PSS-10(β=-0.27,P＜0.001),PHQ-9(β=-0.25,P＜0.001),DERS-16(β=-0.23,P＜0.001),and GAD-7(β=-0.11,P＜0.001)scores were negatively associated with SF-12 mental quality of life scores.The SSS-8 scores were negatively associated with SF-12 physical quality of life scores(β=-0.45,P＜0.001).Conclusion:The study shows that a higher percentage of college students have a lower quality of life;the higher the levels of perceived stress,depression,emotional regulation difficulties,and anxiety,the lower the mental quality of life,and the more severe the physical discomfort symptoms,the lower the physical quality of life.

Objective To investigate serum levels of eosinophilic neurotoxin(EDN),interleukin(IL)-13 and transforming growth factor(TGF)-β1 in children with recurrent wheezing of mycoplasma pneumoniae(MP)infection and analyze risk factors of recurrent wheezing with MP infection.Methods A total of 80 children with MP infection were divided into the MP infection recurrence wheezing group(45 cases)and the MP infection non-wheezing group(35 cases)according to the previous history of MP infection with wheezing,and 35 children with acute attacks of bronchial asthma were selected as the asthma group.The levels of EDN,IL-13 and TGF-β1 were determined by enzyme-linked immunosorbent assay.Multivariate Logistic regression analysis was performed to analyze risk factors of MP infection recurrence and wheezing.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of EDN,IL-13 and TGF-β1 on MP infection recurrence and wheezing.Results Compared with the non-asthmatic group,levels of EDN,IL-13 and TGF-β1 were higher in the recurrent asthmatic group and the asthmatic group(P＜0.05).There were no significant differences in EDN,IL-13 and TGF-β1 levels between the asthma group and the recurrent asthmatic group.Univariate analysis showed that the birth weight was lower in the recurrent wheezing group than that of the non-wheezing group,and the proportion of atopic constitution,the first and second degree relatives allergy history,smoke exposure and hospital stay≥7 d were higher than those of the non-wheezing group(P＜0.05).Multivariate Logistic regression analysis showed that higher levels of EDN,IL-13,TGF-β1,atopic constitution and smoke exposure were risk factors for recurrent wheezing of MP infection(P＜0.05).ROC curve results showed that the AUC of EDN,IL-13 and TGF-β1 for predicting the recurrence of MP infection and wheeting was 0.688,0.662 and 0.689,respectively,and the AUC of the combined prediction of EDN,IL-13 and TGF-β1 was 0.765,which was the most effective than each single index.Conclusion Serum levels of EDN,IL-13 and TGF-β1 increase in children with recurrent wheezing of MP infection,and their serum levels may predict repeated wheezing in children after MP infection,providing guidance for clinical intervention.

Objective To explore the relationship between serum thrombospondin-1(TSP-1),cathepsin S(Cat S),and Visfatin in patients with acute myocardial infarction(AMI)and myocardial microcirculation dis-orders after PCI and their clinical prognostic value.Methods A total of 90 AMI patients who underwent PCI treatment in the hospital from June 2021 to June 2023 were enrolled in the study.They were grouped into a microcirculation disorder group(62 cases)and a normal group(28 cases)based on their myocardial microcir-culation status.According to their postoperative prognosis,they were grouped into a good prognosis group(50 cases)and a poor prognosis group(40 cases).The risk factors of poor prognosis were analyzed by Logistic re-gression,and the predictive value of serum TSP-1,Cat S and Visfatin was analyzed by receiver operating char-acteristic(ROC)curve.Results The serum levels of TSP-1,Cat S,and Visfatin in the microcirculation disor-ders group were higher than those in the normal group,and those in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P＜0.05).Elevated levels of serum TSP-1,Cat S,and Visfatin were risk factors for poor prognosis in AMI patients after PCI(P＜0.05).The efficacy of combined detection of serum TSP-1,Cat S,and Visfatin levels for predicting the prog-nosis of AMI patients after PCI was higher than that of single detection(Zcombinedprediction-TSP-1=2.245,P=0.025,Z combined prediction-Cat S=2.101,P=0.036,Z combined prediction-Visfatin=2.252,P=0.024).Conclusion The serum levels of TSP-1,Cat S and Visfatin are obviously increased in AMI patients with myocardial microcirculation disorders after PCI,and the combination of the three has relatively high efficacy in predicting the prognosis of AMI pa-tients after PCI.

Nonalcoholic fatty liver disease (NAFLD) has become one of the most prominent causes of chronic liver diseases and malignancies. However, few therapy has been approved. Radix Bupleuri (RB) is the most frequently used herbal medicine for the treatment of liver diseases. In the current study, we aim to systemically evaluate the therapeutic effects of saikosaponin A (SSa) and saikosaponin D (SSd), the major bioactive monomers in RB, against NAFLD and to investigate the underlying mechanisms. Our results demonstrated that both SSa and SSd improved diet-induced NAFLD. Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes, like

Objective:To evaluate the application of SBAR mode handover card in transferring patients with mechanical ventilation for hyperbaric oxygen therapy.Methods:A total of 200 patients with mechanical ventilation, who were admitted to Zhejiang Mingzhou Rehabilitation Hospital and needed hyperbaric oxygen therapy from March 2019 to March 2020, were randomized into observation group and control group with 100 subjects in each group. When transferring the patients from ward to hyperbaric oxygen therapy center, the observation group used our self-designed SBAR mode handover card, while the control group used the conventional handover card. The incidence of nursing adverse events, some medical record missing during handover, nurses’ satisfaction rate on the transferring, and average transferring time were compared between the two groups.Results:There were 8 nursing adverse events and 2 cases of some medical record missing during handover in the observation group, which were less than the 21 events and the 11 cases in the control group. The nurses’ satisfaction rate was 96.0% in the observation group, which was significantly higher than that (83.0%) in the control group, with a statistically significance difference ( P<0.05). The average handover time of the observation group [(9.95±1.23) min] was shorter than that of the control group [(22.46±1.38) min], with a statistically significance difference ( P<0.05). Conclusion:SBAR mode handover card can standardize the handover of patients with mechanical ventilation for transferring to hyperbaric oxygen therapy, effectively reduce the occurrence of nursing adverse event and some medical record missing during handover, improve the handover efficiency, and the satisfaction rate of the nurses, so as to ensure the safety of transferring the patients in critical condition.

Objective:To evaluate the application of SBAR mode handover card in transferring patients with mechanical ventilation for hyperbaric oxygen therapy.Methods:A total of 200 patients with mechanical ventilation, who were admitted to Zhejiang Mingzhou Rehabilitation Hospital and needed hyperbaric oxygen therapy from March 2019 to March 2020, were randomized into observation group and control group with 100 subjects in each group. When transferring the patients from ward to hyperbaric oxygen therapy center, the observation group used our self-designed SBAR mode handover card, while the control group used the conventional handover card. The incidence of nursing adverse events, some medical record missing during handover, nurses’ satisfaction rate on the transferring, and average transferring time were compared between the two groups.Results:There were 8 nursing adverse events and 2 cases of some medical record missing during handover in the observation group, which were less than the 21 events and the 11 cases in the control group. The nurses’ satisfaction rate was 96.0% in the observation group, which was significantly higher than that (83.0%) in the control group, with a statistically significance difference ( P<0.05). The average handover time of the observation group [(9.95±1.23) min] was shorter than that of the control group [(22.46±1.38) min], with a statistically significance difference ( P<0.05). Conclusion:SBAR mode handover card can standardize the handover of patients with mechanical ventilation for transferring to hyperbaric oxygen therapy, effectively reduce the occurrence of nursing adverse event and some medical record missing during handover, improve the handover efficiency, and the satisfaction rate of the nurses, so as to ensure the safety of transferring the patients in critical condition.

As one of the common types of hallucinations, auditory verbal hallucinations (AVHs) frequently occur across multiple psychiatric diseases especially in patients with schizophrenia (SCZ). Nevertheless, the a etiology and pathogenesis of it remain unclear. Currently, several interventions showed limited efficacy in treating AVHs. AVATAR therapy aiding for AVHs in people with psychosis has received growing attention during the past few years. Previous studies indicated that AVATAR therapy could significantly alleviate the frequency, duration, beliefs re-origin of voices and intensity of distress. Therefore, the current study systematically reviewed AVATAR therapy for AVHs, including the specific therapy processes, limitations in existing literature, and future research and clinical implications, to improve the clinical treatment and provide insights for exploring the pathogenesis, and prognosis of AVHs.

As one of the common types of hallucinations, auditory verbal hallucinations (AVHs) frequently occur across multiple psychiatric diseases especially in patients with schizophrenia (SCZ). Nevertheless, the a etiology and pathogenesis of it remain unclear. Currently, several interventions showed limited efficacy in treating AVHs. AVATAR therapy aiding for AVHs in people with psychosis has received growing attention during the past few years. Previous studies indicated that AVATAR therapy could significantly alleviate the frequency, duration, beliefs re-origin of voices and intensity of distress. Therefore, the current study systematically reviewed AVATAR therapy for AVHs, including the specific therapy processes, limitations in existing literature, and future research and clinical implications, to improve the clinical treatment and provide insights for exploring the pathogenesis, and prognosis of AVHs.